Abstract
The manuscript describes the methods that are most often used in the preparation of N-heterocyclic carbene (NHC) complexes. These methods include: (1) insertion of a metal into the C = C bond of bis(imidazolidin-2-ylidene) olefins; (2) use of carbene adducts or “protected” forms of free NHC carbenes; (3) use of preformed, isolated free carbenes; (4) deprotonation of an azolium salt with a base; (5) transmetallation from an Ag — NHC complex prepared from direct reaction of an imidazolium precursor and Ag2O; and (6) oxidative addition via activation of the C2 — X (X = Me, halogen, H) of an imidazolium cation.
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Peris, E. (2006). Routes to N-Heterocyclic Carbene Complexes. In: N-Heterocyclic Carbenes in Transition Metal Catalysis. Topics in Organometallic Chemistry, vol 21. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-36930-1_4
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