Skip to main content

Wound Healing and Stress

  • Chapter
Neuroimmunology of the Skin

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Ahlquist RP (1976) Present state of alpha- and beta-adrenergic drugs I. The adrenergic receptor. Am Heart J 92:661–664

    PubMed  CAS  Google Scholar 

  2. Altemus M, Rao B, Dhabhar FS, Ding W, Granstein RD (2001) Stress-induced changes in skin barrier function in healthy women. J Invest Dermatol 117:309–317

    PubMed  CAS  Google Scholar 

  3. Ashcroft GS, Horan MA, Ferguson MW (1995) The effects of ageing on cutaneous wound healing in mammals. J Anat 187:1–26

    PubMed  Google Scholar 

  4. Ashcroft GS, Kielty CM, Horan MA, Ferguson MW (1997) Age-related changes in the temporal and spatial distributions of fibrillin and elastin mRNAs and proteins in acute cutaneous wounds of healthy humans. J Pathol 183:80–89

    PubMed  CAS  Google Scholar 

  5. Ashcroft GS, Mills SJ, Ashworth JJ (2002) Ageing and wound healing. Biogerontology 3:337–345

    PubMed  CAS  Google Scholar 

  6. Beer HD, Fassler R, Werner S (2000) Glucocorticoid-regulated gene expression during cutaneous wound repair. VitamHorm 59:217–239

    CAS  Google Scholar 

  7. Beilin B, Shavit Y, Trabekin E, Mordashev B, Mayburd E, Zeidel A, Bessler H (2003) The effects of postoperative pain management on immune response to surgery. Anesth Analg 97:822–827

    PubMed  Google Scholar 

  8. Berczi I (1986) The influence of pituitary-adrenal axis on the immune system. In: Berczi I (ed) Pituitary Function and Immunity. CRC Press, Boca Raton, Florida, p 49

    Google Scholar 

  9. Black PH, Berman AS (1999) Stress and inflammation. In: Plotnikoff NP, Faith RE, Murgo AJ, Good RA (eds) Cytokines: Stress and Immunity. CRC Press, Boca Raton, Florida, pp 115–132

    Google Scholar 

  10. Bosch JA, Engeland CG, Cacioppo JT, Marucha PT (2007) Depressive symptoms predict mucosal wound healing. Psychosom Med 69:597–605

    PubMed  Google Scholar 

  11. Boyapati L, Wang HL (2007) The role of stress in periodontal disease and wound healing. Periodontol 2000 44:195–210

    PubMed  Google Scholar 

  12. Brauchle M, Fassler R, Werner S (1995) Suppression of keratinocyte growth factor expression by glucocorticoids in vitro and during wound healing. J Invest Dermatol 105:579–584

    PubMed  CAS  Google Scholar 

  13. Broadbent E, Petrie KJ, Alley PG, Booth RJ (2003) Psychological stress impairs early wound repair following surgery. Psychosom Med 65:865–869

    PubMed  Google Scholar 

  14. Brown DH, Sheridan J, Pearl D, Zwilling BS (1993) Regulation of mycobacterial growth by the hypothalamus-pituitary-adrenal axis: differential responses of Mycobacterium bovis BCG-resistant and -susceptible mice. Infect Immun 61:4793–4800

    PubMed  CAS  Google Scholar 

  15. Chang N, Goodson WH III, Gottrup F, Hunt TK (1983) Direct measurement of wound and tissue oxygen tension in postoperative patients. Ann Surg 197:470–478

    PubMed  CAS  Google Scholar 

  16. Chedid M, Hoyle JR, Csaky KG, Rubin JS (1996) Glucocorticoids inhibit keratinocyte growth factor production in primary dermal fibroblasts. Endocrinology 137:2232–2237

    PubMed  CAS  Google Scholar 

  17. Chrousos GP (1998) Stressors, stress, and neuroendocrine integration of the adaptive response. The 1997 Hans Selye Memorial Lecture. Ann NY Acad Sci 851:311–335

    PubMed  CAS  Google Scholar 

  18. Clark RA, Gallin JI, Fauci AS (1979) Effects of in vivo prednisone on in vitro eosinophil and neutrophil adherence and chemotaxis. Blood 53:633–641

    PubMed  CAS  Google Scholar 

  19. Cole-King A, Harding KG (2001) Psychological factors and delayed healing in chronic wounds. Psychosom Med 63:216–220

    PubMed  CAS  Google Scholar 

  20. Cook JL, Dzubow LM (1997) Aging of the skin: implications for cutaneous surgery. Arch Dermatol 133:1273–1277

    PubMed  CAS  Google Scholar 

  21. Denda M, Tsuchiya T, Elias PM, Feingold KR (2000) Stress alters cutaneous permeability barrier homeostasis. Am J Physiol Regul Integr Comp Physiol 278:R367–R372

    PubMed  CAS  Google Scholar 

  22. DeRijk R, Michelson D, Karp B, Petrides J, Galliven E, Deuster P, Paciotti G, Gold PW, Sternberg EM (1997) Exercise and circadian rhythm-induced variations in plasma cortisol differentially regulate interleukin-1 beta (IL-1 beta), IL-6, and tumor necrosis factor-alpha (TNF alpha) production in humans: high sensitivity of TNF alpha and resistance of IL-6. J Clin Endocrinol Metab 82:2182–2191

    PubMed  CAS  Google Scholar 

  23. Detillion CE, Craft TK, Glasper ER, Prendergast BJ, Devries AC (2004) Social facilitation of wound healing. Psychoneuroendocrinology 29:1004–1011

    PubMed  CAS  Google Scholar 

  24. Devine EC (1992) Effects of psychoeducational care for adult surgical patients: a meta-analysis of 191 studies. Patient Educ Couns 19:129–142

    PubMed  CAS  Google Scholar 

  25. Devries AC, Craft TK, Glasper ER, Neigh GN, Alexander JK (2007) 2006 Curt P. Richter award winner Social influences on stress responses and health. Psychoneuroendocrinology 32:587–603

    PubMed  Google Scholar 

  26. Dhabhar FS (2003) Stress, leukocyte trafficking, and the augmentation of skin immune function. Ann NY Acad Sci 992:205–217

    PubMed  CAS  Google Scholar 

  27. Donaldson DJ, Mahan JT (1984) Influence of catecholamines on epidermal cell migration during wound closure in adult newts. Comp Biochem Physiol C 78:267–270

    PubMed  CAS  Google Scholar 

  28. Dovi JV, He LK, DiPietro LA (2003) Accelerated wound closure in neutrophil-depleted mice. J Leukoc Biol 73:448–455

    PubMed  CAS  Google Scholar 

  29. Dovi JV, Szpaderska AM, DiPietro LA (2004) Neutrophil function in the healing wound: adding insult to injury? Thromb Haemost 92:275–280

    PubMed  CAS  Google Scholar 

  30. Ebrecht M, Hextall J, Kirtley LG, Taylor A, Dyson M, Weinman J (2004) Perceived stress and cortisol levels predict speed of wound healing in healthy male adults. Psychoneuroendocrinology 29:798–809

    PubMed  CAS  Google Scholar 

  31. Edwards JC, Dunphy JE (1958) Wound healing. II. Injury and abnormal repair. N Eng J Med 259:275–285

    CAS  Google Scholar 

  32. Eijkelkamp N, Engeland CG, Gajendrareddy PK, Marucha PT (2007) Restraint stress impairs early wound healing in mice via alpha-adrenergic but not beta-adrenergic receptors. Brain Behav Immun 21:409–412

    PubMed  CAS  Google Scholar 

  33. Elenkov IJ, Chrousos GP (2006) Stress system-organization, physiology and immunoregulation. Neuroimmunomodulation 13:257–267

    PubMed  CAS  Google Scholar 

  34. Eming S, Kreig T, Davidson JM (2007) Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermato 127:514–525

    CAS  Google Scholar 

  35. Engeland CG, Bosch JA, Cacioppo JT, Marucha PT (2006) Mucosal wound healing: the roles of age and sex. Arch Surg 141:1193–1197

    PubMed  Google Scholar 

  36. England GT, Randall HW, Graves WL (1983) Impairment of tissue defenses by vasoconstrictors in vaginal hysterectomies. Obstet Gynecol 61:271–274

    PubMed  CAS  Google Scholar 

  37. Fauci AS, Dale DC, Balow JE (1976) Glucocorticosteroid therapy: mechanisms of action and clinical considerations. Ann Intern Med 84:304–315

    PubMed  CAS  Google Scholar 

  38. Fenske NA, Lober CW (1986) Structural and functional changes of normal aging skin. J Am Acad Dermatol 15:571–585

    PubMed  CAS  Google Scholar 

  39. Field T, Peck M, Krugman S, Tuchel T, Schanberg S, Kuhn C, Burman I (1998) Burn injuries benefit from massage therapy. J Burn Care Rehabil 19:241–244

    PubMed  CAS  Google Scholar 

  40. Gajendrareddy PK, Sen CK, Horan MP, Marucha PT (2005) Hyperbaric oxygen therapy ameliorates stress-impaired dermal wound healing. Brain Behav Immun 19:217–222

    PubMed  CAS  Google Scholar 

  41. Gallucci RM, Simeonova PP, Matheson JM, Kommineni C, Guriel JL, Sugawara T, Luster MI (2000) Impaired cutaneous wound healing in interleukin-6-deficient and immuno-suppressed mice. FASEB J 14:2525–2531

    PubMed  CAS  Google Scholar 

  42. Gallucci RM, Sugawara T, Yucesoy B, Berryann K, Simeonova PP, Matheson JM, Luster MI (2001) Interleukin-6 treatment augments cutaneous wound healing in immunosuppressed mice. J Interferon Cytokine Res 21:603–609

    PubMed  CAS  Google Scholar 

  43. Garg A, Chren MM, Sands LP, Matsui MS, Marenus KD, Feingold KR, Elias PM (2001) Psychological stress perturbs epidermal permeability barrier homeostasis: implications for the pathogenesis of stress-associated skin disorders. Arch Dermatol 137:53–59

    PubMed  CAS  Google Scholar 

  44. Gerstein AD, Phillips TJ, Rogers GS, Gilchrest BA (1993) Wound healing and aging. Dermatol Clin 11:749–757

    PubMed  CAS  Google Scholar 

  45. Glaser R, Kiecolt-Glaser JK, Marucha PT, MacCallum RC, Laskowski BF, Malarkey WB (1999) Stress-related changes in proinflammatory cytokine production in wounds. Arch Gen Psychiatr 56:450–456

    PubMed  CAS  Google Scholar 

  46. Glaser R, Sheridan J, Malarkey WB, MacCallum RC, Kiecolt-Glaser JK (2000) Chronic stress modulates the immune response to a pneumococcal pneumonia vaccine. Psychosom Med 62:804–807

    PubMed  CAS  Google Scholar 

  47. Glaser R, Kiecolt-Glaser JK (2005) Stress-induced immune dysfunction: implications for health. Nat Rev Immunol 5:243–251

    PubMed  CAS  Google Scholar 

  48. Glasper ER, Devries AC (2005) Social structure influences effects of pair-housing on wound healing. Brain Behav Immun 19:61–68

    PubMed  Google Scholar 

  49. Goodson WH III, Hunt TK (1979) Wound healing and aging. J Invest Dermatol 73:88–91

    PubMed  Google Scholar 

  50. Gosain A, DiPietro LA (2004) Aging and wound healing. World J Surg 28:321–326

    PubMed  Google Scholar 

  51. Gosain A, Jones SB, Shankar R, Gamelli RL, DiPietro LA (2006) Norepinephrine modulates the inflammatory and proliferative phases of wound healing. J Trauma 60:736–744

    PubMed  CAS  Google Scholar 

  52. Graham JE, Christian LM, Kiecolt-Glaser JK (2006) Stress, age, and immune function: toward a lifespan approach. J Behav Med 29:389–400

    PubMed  Google Scholar 

  53. Gupta A, Jain GK, Raghubir R (1999) A time course study for the development of an immunocompromised wound model, using hydrocortisone. J Pharmacol Toxicol Methods 41:183–187

    PubMed  CAS  Google Scholar 

  54. Hawkley LC, Bosch JA, Engeland CG, Cacioppo JT, Marucha PT (2007) Loneliness, dysphoria, stress, and immunity: a role for cytokines. In: Plotnikoff NP, Faith RE, Murgo AJ (eds) Cytokines: Stress and Immunity. CRC Press, Boca Raton, Florida, pp 67–85

    Google Scholar 

  55. Head CC, Farrow MJ, Sheridan JF, Padgett DA (2006) Androstenediol reduces the anti-inflammatory effects of restraint stress during wound healing. Brain Behav Immun 20:590–596

    PubMed  CAS  Google Scholar 

  56. Hinz B (2007) Formation and function of the myofibroblast during tissue repair. J Invest Dermatol 127:526–537

    PubMed  CAS  Google Scholar 

  57. Holden-Lund C (1988) Effects of relaxation with guided imagery on surgical stress and wound healing. Res Nurs Health 11:235–244

    PubMed  CAS  Google Scholar 

  58. Hopf HW, Rollins MD (2007) Wounds: an overview of the role of oxygen. Antioix Redox Signal 8:1183–1192

    Google Scholar 

  59. Hopf HW, Hunt TK, West JM, Blomquist P, Goodson WH III, Jensen JA, Jonsson K, Paty PB, Rabkin JM, Upton RA, von Smitten K, Whitney JD (1997) Wound tissue oxygen tension predicts the risk of wound infection in surgical patients. Arch Surg 132:997–1004

    PubMed  CAS  Google Scholar 

  60. Horan MP, Quan N, Subramanian SV, Strauch AR, Gajendrareddy PK, Marucha PT (2005) Impaired wound contraction and delayed myofibroblast differentiation in restraint-stressed mice. Brain Behav Immun 19:207–216

    PubMed  CAS  Google Scholar 

  61. Hubner G, Brauchle M, Smola H, Madiener M, Fassler R, Werner S (1996) Differential regulation of pro-inflammatory cytokines during wound healing in normal and glucocorticoid-treated mice. Cytokine 8:548–556

    PubMed  CAS  Google Scholar 

  62. Hunt TK, Pai MP (1972) The effect of varying ambient oxygen tensions on wound metabolism and collagen synthesis. Surg Gynecol Obstet 135:561–567

    PubMed  CAS  Google Scholar 

  63. Irwin M (2002) Effects of sleep and sleep loss on immunity and cytokines. Brain Behav Immun 16:503–512

    PubMed  CAS  Google Scholar 

  64. Jensen JA, Jonsson K, Goodson WH III, Hunt TK, Roizen MF (1985) Epinephrine lowers subcutaneous wound oxygen tension. Curr Surg 42:472–474

    PubMed  CAS  Google Scholar 

  65. Jonsson K, Hunt TK, Mathes SJ (1988) Oxygen as an isolated variable influences resistance to infection. Ann Surg 208:783–787

    PubMed  CAS  Google Scholar 

  66. Jorgensen LN, Kallehave F, Christensen E, Siana JE, Gottrup F (1998) Less collagen production in smokers. Surgery 123:450–455

    PubMed  CAS  Google Scholar 

  67. Kalin NH, Shelton SE, Engeland CG, Haraldsson HM, Marucha PT (2006) Stress decreases, while central nucleus amygdala lesions increase, IL-8 and MIP-lalpha gene expression during tissue healing in non-human primates. Brain Behav Immun 6:564–568

    Google Scholar 

  68. Kiecolt-Glaser JK, Marucha PT, Malarkey WB, Mercado AM, and Glaser R (1995) Slowing of wound healing by psychological stress. Lancet 346:1194–1196

    PubMed  CAS  Google Scholar 

  69. Kiecolt-Glaser JK, Glaser R, Gravenstein S, Malarkey WB, Sheridan J (1996) Chronic stress alters the immune response to influenza virus vaccine in older adults. Proc Natl Acad Sci USA 93:3043–3047

    PubMed  CAS  Google Scholar 

  70. Kiecolt-Glaser JK, Loving TJ, Stowell JR, Malarkey WB, Lemeshow S, Dickinson SL, Glaser R (2005) Hostile marital interactions, proinflammatory cytokine production, and wound healing. Arch Gen Psychiatr 62:1377–1384

    PubMed  Google Scholar 

  71. Kinsey SG, Prendergast BJ, Nelson RJ (2003) Photoperiod and stress affect wound healing in Siberian hamsters. Physiol Behav 78:205–211

    PubMed  CAS  Google Scholar 

  72. Kirschbaum C, Pirke KM, Hellhammer DH (1993) The ‘Trier Social Stress Test’ — a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology 28:76–81

    PubMed  CAS  Google Scholar 

  73. Knuutinen A, Kokkonen N, Risteli J, Vahakangas K, Kallioinen M, Salo T, Sorsa T, Oikarinen A (2002) Smoking affects collagen synthesis and extracellular matrix turnover in human skin. Br J Dermatol 146:588–594

    PubMed  CAS  Google Scholar 

  74. Koga C, Itoh K, Aoki M, Suefuji Y, Yoshida M, Asosina S, Esaki K, Kameyama T (2001) Anxiety and pain suppress the natural killer cell activity in oral surgery outpatients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91:654–658

    PubMed  CAS  Google Scholar 

  75. Koopman CF (1995) Cutaneous wound healing, an overview. Otolaryngol Clin North Am 28:835–845

    Google Scholar 

  76. Kovacs EJ (2005) Aging, traumatic injury, and estrogen treatment. Exp Gerontol 40:549–555

    PubMed  CAS  Google Scholar 

  77. Linn BS, Linn MW, Klimas NG (1988) Effects of psychophysical stress on surgical outcome. Psychosom Med 50:230–244

    PubMed  CAS  Google Scholar 

  78. Marucha PT, Kiecolt-Glaser JK, Favagehi M (1998) Mucosal wound healing is impaired by examination stress. Psychosom Med 60:362–365

    PubMed  CAS  Google Scholar 

  79. Mastorakos G, Bamberger C, Chrousos GP (1999) Neuroendocrine regulation of the immune process. In: Plotnikoff NP, Faith RE, Murgo AJ, Good RA (eds) Cytokines: stress and immunity. CRC Press, Boca Raton, Florida, pp 17–37

    Google Scholar 

  80. McEwen BS, Stellar E (1993). Stress and the individual: mechanisms leading to disease. Arch Internal Med 153:2093–2101

    CAS  Google Scholar 

  81. McGuire L, Heffner K, Glaser R, Needleman B, Malarkey W, Dickinson S, Lemeshow S, Cook C, Muscarella P, Melvin WS, Ellison EC, Kiecolt-Glaser JK (2006) Pain and wound healing in surgical patients. Ann Behav Med 31:165–172

    PubMed  Google Scholar 

  82. Mercado AM, Padgett DA, Sheridan JF, Marucha PT (2002) Altered kinetics of IL-1 alpha, IL-1 beta, and KGF-1 gene expression in early wounds of restrained mice. Brain Behav Immun 16:150–162

    PubMed  CAS  Google Scholar 

  83. Moller AM, Villebro N, Pedersen T, Tonnesen H (2002) Effect of preoperative smoking intervention on postoperative complications: a randomised clinical trial. Lancet 359:114–117

    PubMed  Google Scholar 

  84. Muizzuddin N, Matsui MS, Marenus KD, Maes DH (2003) Impact of stress of marital dissolution on skin barrier recovery: tape stripping and measurement of trans-epidermal water loss (TEWL). Skin Res Technol 9:34–38

    PubMed  Google Scholar 

  85. Norris DA, Capin L, Weston WL (1982) The effect of epicutaneous glucocorticosteroids on human monocyte and neutrophil migration in vivo. J Invest Dermatol 78:386–390

    PubMed  CAS  Google Scholar 

  86. Padgett DA, Marucha PT, Sheridan JF (1998) Restraint stress slows cutaneous wound healing in mice. Brain Behav Immun 12:64–73

    PubMed  CAS  Google Scholar 

  87. Page-McCaw A, Ewald A, Werb Z (2007) Matrix metalloproteinases and the regulation of tissue remodeling. Nat Rev Mol Cell Biol 8:221–233

    PubMed  CAS  Google Scholar 

  88. Pai MP, Hunt TK (1972) Effect of varying oxygen tensions on healing of open wounds. Surg Gynecol Obstet 135:756–758

    PubMed  CAS  Google Scholar 

  89. Pullar CE, Isseroff RR (2006) The beta 2-adrenergic receptor activates pro-migratory and pro-proliferative pathways in dermal fibroblasts via divergent mechanisms. J Cell Sci 119:592–602

    PubMed  CAS  Google Scholar 

  90. Pullar CE, Grahn JC, Liu W, Isseroff RR (2006) Beta2-adrenergic receptor activation delays wound healing. FASEB J 20:76–86

    PubMed  CAS  Google Scholar 

  91. Pullar CE, Rizzo A, Isseroff RR (2006) Beta-Adrenergic receptor antagonists accelerate skin wound healing: evidence for a catecholamine synthesis network in the epidermis. J Biol Chem 281:21225–21235

    PubMed  CAS  Google Scholar 

  92. Quirinia A, Viidik A (1991) The influence of age on the healing of normal and ischemic incisional skin wounds. Mech Ageing Dev 58:221–232

    PubMed  CAS  Google Scholar 

  93. Raja, Sivamani K, Garcia MS, Isseroff RR (2007) Wound re-epthelialization: modulating keratinocyte migration in wound healing. Front Biosci 12:2849–2868

    PubMed  CAS  Google Scholar 

  94. Rico RM, Ripamonti R, Burns AL, Gamelli RL, DiPietro LA (2002) The effect of sepsis on wound healing. J Surg Res 102:193–197

    PubMed  Google Scholar 

  95. Robson MC (1997) Wound infection. A failure of wound healing caused by an imbalance of bacteria. Surg Clin North Am 77:637–650

    PubMed  CAS  Google Scholar 

  96. Robson MC, Heggers JP (1969) Bacterial quantification of open wounds. Mil Med 134:19–24

    PubMed  CAS  Google Scholar 

  97. Rojas IG, Padgett DA, Sheridan JF, Marucha PT (2002) Stress-induced susceptibility to bacterial infection during cutaneous wound healing. Brain Behav Immun 16:74–84

    PubMed  Google Scholar 

  98. Ryan TJ (2007) Infection following soft tissue injury: its role in wound healing. Curr Opin Infect Dis 20:124–128

    PubMed  Google Scholar 

  99. Sanders VM, Straub RH (2002) Norepinephrine, the beta-adrenergic receptor, and immunity. Brain Behav Immun 16:290–332

    PubMed  CAS  Google Scholar 

  100. Sapolsky RM, Krey LC, McEwen BS (1986). The neuroendocrinology of stress and aging: the glucocorticoid casade hypothesis. Endocrin Rev 7:284–301

    CAS  Google Scholar 

  101. Schiepers OJ, Wichers MC, Maes M (2005) Cytokines and major depression. Prog Neuropsychopharmacol Biol Psychiatry 29:201–217

    PubMed  CAS  Google Scholar 

  102. Sheridan JF, Stark JL, Avitsur R, Padgett DA (2000) Social disruption, immunity, and susceptibility to viral infection. Role of glucocorticoid insensitivity and NGF. Ann NY Acad Sci 917:894–905

    PubMed  CAS  Google Scholar 

  103. Sheridan JF, Padgett DA, Avitsur R, Marucha PT (2004) Experimental models of stress and wound healing. World J Surg 28:327–330

    PubMed  Google Scholar 

  104. Shurin MR, Kusnecov A, Hamill E, Kaplan S, Rabin BS (1994) Stress-induced alteration of polymorphonuclear leukocyte function in rats. Brain Behav Immun 8:163–169

    PubMed  CAS  Google Scholar 

  105. Starkweather AR, Witek-Janusek L, Nockels RP, Peterson J, Mathews HL (2006) Immune function, pain, and psychological stress in patients undergoing spinal surgery. Spine 31:E641–E647

    PubMed  Google Scholar 

  106. Stramer BM, Mori R, Martin P (2007) The Inflammation-fibrosis link? A Jekyll and Hyde role for blood cells during wound repair. J Invest Dermatol 127:1009–1017

    PubMed  CAS  Google Scholar 

  107. Strecker-McGraw MK, Jones TR, Baer DG (2007) Soft tissue wounds and principles of healing. Emerg Med Clin N Am 25:1–22

    Google Scholar 

  108. Swift ME, Kleinman HK, DiPietro LA (1999) Impaired wound repair and delayed angiogenesis in aged mice. Lab Invest 79:1479–1487

    PubMed  CAS  Google Scholar 

  109. Thomas DR (2001) Age-related changes in wound healing. Drugs Aging 18:607–620

    PubMed  CAS  Google Scholar 

  110. van de Kerkhof PC, Van Bergen B, Spruijt K, Kuiper JP (1994) Age-related changes in wound healing. Clin Exp Dermatol 19:369–374

    PubMed  Google Scholar 

  111. Werner S, Kreig T, Smola H (2007) Keratinocyte-fibroblast interactions in wound healing. J Invest Dermatol 127:998–1008

    PubMed  CAS  Google Scholar 

  112. Whitney JD (1989) Physiologic effects of tissue oxygenation on wound healing. Heart Lung 18:466–474

    PubMed  CAS  Google Scholar 

  113. Wilgus TA (2007) Regenerative healing in fetal skin: a review of the literature. Ostomy Wound Manage 53:16–31

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to C. G. Engeland or P. T. Marucha .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Engeland, C.G., Marucha, P.T. (2009). Wound Healing and Stress. In: Granstein, R.D., Luger, T.A. (eds) Neuroimmunology of the Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-35989-0_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-35989-0_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-35986-9

  • Online ISBN: 978-3-540-35989-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics