Abstract
There has always been some doubt whether the fruit fly Drosophila melanogaster might help us to a better understanding of differentiation in higher organisms inasmuch as “it is rather unfortunate that Drosophila, the classical object of genetic research, should happen to have a mosaic type of development” (Needham, 1950). I do not think that it is superfluous to remind ourselves that during the past two decades, however, this gloomy notion has become irrelevant since new genetic and microsurgical approaches opened up novel ways of analyzing nucleocytoplasmic interactions during cellular diversification (reviewed by Gehring, 1976a; Schneiderman, 1976). Moreover, Drosophila proved to be an ideal organism for the production of mosaic individuals composed of two genetically different cell populations. By utilizing appropriate marker genes in combination with X-irradiation induced mitotic recombination (reviewed by Becker, this volume), chromosomal loss (reviewed by Janning and Wieschaus, this volume), or microinjection (discussed in this contribution), it is now possible to trace phenotypically the origin and fate of “genetically labeled” cells and their clonal descendants during the course of development.
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Illmensee, K. (1978). Drosophila Chimeras and the Problem of Determination. In: Gehring, W.J. (eds) Genetic Mosaics and Cell Differentiation. Results and Problems in Cell Differentiation, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-35803-9_3
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DOI: https://doi.org/10.1007/978-3-540-35803-9_3
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