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The Structurally Constrained Neutral Model of Protein Evolution

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Structural Approaches to Sequence Evolution

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

The observation that protein sequences accumulate substitutions in time at an almost regular rate [1] created a great interest in molecular evolution, suggesting that substitutions in protein sequences can be used as an effective ‘molecular clock’ for estimating the time elapsed from the last common ancestor among genes [1-5]. This approach opened a new avenue for reconstructing the tree of life by analyzing the sequences of orthologous genes, whose evolutionary tree coincides with the tree of the species containing them. The practical importance of the study of molecular evolution became therefore evident as a way to reconstruct natural histories.

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Authors and Affiliations

  1. Fac. de Ciencias, Universidad Autonoma Madrid, Cantoblanco, 28049, Madrid, Spain

    Dr. Ugo Bastolla

  2. Institut fur Festkorperphysik, TU Darmstadt, Hochschulstr. 8, 64289, Darmstadt, Germany

    Professor Dr. Markus Porto

  3. Dipartimento di Fisica, Universita di Milano-Bicocca, Piazza della Scienza 3, 29126, Milano, Italy

    Dr. H. Eduardo Roman

  4. Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK

    Dr. Michele Vendruscolo

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  1. Dr. Ugo Bastolla
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Editors and Affiliations

  1. Fac. de Ciencias, Universidad Autonoma Madrid, Cantoblanco, 28049, Madrid, Spain

    Ugo Bastolla

  2. Institut für Festkörperphysik, TU Darmstadt, Hochschulstr. 8, 64289, Darmstadt, Germany

    Markus Porto

  3. Dipartimento di Fisica, Universita di Milano-Bicocca, Piazza della Scienza 3, 29126, Milano, Italy

    H. Eduardo Roman

  4. Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK

    Michele Vendruscolo

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Bastolla, U., Porto, M., Roman, H.E., Vendruscolo, M. (2007). The Structurally Constrained Neutral Model of Protein Evolution. In: Bastolla, U., Porto, M., Roman, H.E., Vendruscolo, M. (eds) Structural Approaches to Sequence Evolution. Biological and Medical Physics, Biomedical Engineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-35306-5_4

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