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TRPV Channels’ Role in Osmotransduction and Mechanotransduction

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Book cover Transient Receptor Potential (TRP) Channels

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 179))

Abstract

In signal transduction of metazoan cells, transient receptor potential (TRP) ion channels have been identified that respond to diverse external and internal stimuli, among them osmotic and mechanical stimuli. This chapter will summarize findings on the TRPV subfamily, both its vertebrate and invertebrate members. Of the six mammalian TRPV channels, TRPV1, -V2, and -V4 were demonstrated to function in transduction of osmotic and/or mechanical stimuli. TRPV channels have been found to function in cellular as well as systemic osmotic homeostasis in vertebrates. Invertebrate TRPV channels, five in Caenorhabditis elegans and two in Drosophila, have been shown to play a role in mechanosensation, such as hearing and proprioception in Drosophila and nose touch in C. elegans, and in the response to osmotic stimuli in C. elegans. In a striking example of evolutionary conservation of function, mammalian TRPV4 has been found to rescue mechanosensory and osmosensory deficits of the TRPV mutant line osm-9 in C. elegans, despite no more than 26% orthology of the respective amino acid sequences.

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References

  • Alessandri-Haber N, Dina OA, Yeh JJ, Parada CA, Reichling DB, Levine JD (2004) Transient receptor potential vanilloid 4 is essential in chemotherapy-induced neuropathic pain in the rat. J Neurosci 24:4444–4452

    Article  PubMed  CAS  Google Scholar 

  • Alessandri-Haber N, Joseph E, Dina OA, Liedtke W, Levine JD (2005) TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator. Pain 118:70–79

    Article  PubMed  CAS  Google Scholar 

  • Allessandri-Haber N, Yeh J, Boyd AE, Parada CA, Chen X, Reichling DB, Levine JD (2003) Hypotonicity induces TRPV4-mediated nociception in rat. Neuron 39:497–511

    Article  Google Scholar 

  • Andrade YN, Fernandes J, Vazquez E, Fernandez-Fernandez JM, Arniges M, Sanchez TM, Villalon M, Valverde MA (2005) TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity. J Cell Biol 168:869–874

    Article  PubMed  CAS  Google Scholar 

  • Apostolidis A, Brady CM, Yiangou Y, Davis J, Fowler CJ, Anand P (2005) Capsaicin receptor TRPV1 in urothelium of neurogenic human bladders and effect of intravesical resiniferatoxin. Urology 65:400–405

    Article  PubMed  Google Scholar 

  • Arniges M, Vazquez E, Fernandez-Fernandez JM, Valverde MA (2004) Swelling-activated Ca2+ entry via TRPV4 channel is defective in cystic fibrosis airway epithelia. J Biol Chem 279:54062–54068

    Article  PubMed  CAS  Google Scholar 

  • Arniges M, Fernandez-Fernandez JM, Albrecht N, Schaefer M, Valverde MA (2005) Human TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and trafficking. J Biol Chem 281:8990

    Article  Google Scholar 

  • Bargmann CI, Kaplan JM (1998) Signal transduction in the Caenorhabditis elegans nervous system. Annu Rev Neurosci 21:279–308

    Article  PubMed  CAS  Google Scholar 

  • Becker D, Blase C, Bereiter-Hahn J, Jendrach M (2005) TRPV4 exhibits a functional role in cell-volume regulation. J Cell Sci 118:2435–2440

    Article  PubMed  CAS  Google Scholar 

  • Birder LA, Nakamura Y, Kiss S, Nealen ML, Barrick S, Kanai AJ, Wang E, Ruiz G, De Groat WC, Apodaca G, Watkins S, Caterina MJ (2002) Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nat Neurosci 5:856–860

    Article  PubMed  CAS  Google Scholar 

  • Caterina MJ, Julius D (1999) Sense and specificity: a molecular identity for nociceptors. Curr Opin Neurobiol 9:525–530

    Article  PubMed  CAS  Google Scholar 

  • Caterina MJ, Montell C (2005) Take a TRP to beat the heat. Genes Dev 19:415–418

    Article  PubMed  CAS  Google Scholar 

  • Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816–824

    Article  PubMed  CAS  Google Scholar 

  • Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D (1999) A capsaicin-receptor homologue with a high threshold for noxious heat. Nature 398:436–441

    Article  PubMed  CAS  Google Scholar 

  • Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288:306–313

    Article  PubMed  CAS  Google Scholar 

  • Chan CL, Facer P, Davis JB, Smith GD, Egerton J, Bountra C, Williams NS, Anand P (2003) Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency. Lancet 361:385–391

    Article  PubMed  CAS  Google Scholar 

  • Chang Q, Hoefs S, van der Kemp AW, Topala CN, Bindels RJ, Hoenderop JG (2005) The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel. Science 310:490–493

    Article  PubMed  CAS  Google Scholar 

  • Clapham DE (2003) TRP channels as cellular sensors. Nature 426:517–524

    Article  PubMed  CAS  Google Scholar 

  • Colbert HA, Smith TL, Bargmann CI (1997) OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans. J Neurosci 17:8259–8269

    PubMed  CAS  Google Scholar 

  • Corey DP, Garcia-Anoveros J, Holt JR, Kwan KY, Lin SY, Vollrath MA, Amalfitano A, Cheung EL, Derfler BH, Duggan A, Geleoc GS, Gray PA, Hoffman MP, Rehm HL, Tamasauskas D, Zhang DS (2004) TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature 432:723–730

    Article  PubMed  CAS  Google Scholar 

  • Cosens DJ, Manning A (1969) Abnormal electroretinogram from a Drosophila mutant. Nature 224:285–287

    Article  PubMed  CAS  Google Scholar 

  • Davis JB, Gray J, Gunthorpe MJ, Hatcher JP, Davey PT, Overend P, Harries MH, Latcham J, Clapham C, Atkinson K, Hughes SA, Rance K, Grau E, Harper AJ, Pugh PL, Rogers DC, Bingham S, Randall A, Sheardown SA (2000) Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature 405:183–187

    Article  PubMed  CAS  Google Scholar 

  • Delany NS, Hurle M, Facer P, Alnadaf T, Plumpton C, Kinghorn I, See CG, Costigan M, Anand P, Woolf CJ, Crowther D, Sanseau P, Tate SN (2001) Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2. Physiol Genomics 4:165–174

    PubMed  CAS  Google Scholar 

  • den Dekker E, Hoenderop JG, Nilius B, Bindels RJ (2003) The epithelial calcium channels, TRPV5 and TRPV6: from identification towards regulation. Cell Calcium 33:497–507

    Article  Google Scholar 

  • Dina OA, Chen X, Reichling D, Levine JD (2001) Role of protein kinase Cepsilon and protein kinase A in a model of paclitaxel-induced painful peripheral neuropathy in the rat. Neuroscience 108:507–515

    Article  PubMed  CAS  Google Scholar 

  • Dinis P, Charrua A, Avelino A, Yaqoob M, Bevan S, Nagy I, Cruz F (2004) Anandamide-evoked activation of vanilloid receptor 1 contributes to the development of bladder hyperreflexia and nociceptive transmission to spinal dorsal horn neurons in cystitis. J Neurosci 24:11253–11263

    Article  PubMed  CAS  Google Scholar 

  • Gao X, Wu L, O’Neil RG (2003) Temperature-modulated diversity of TRPV4 channel gating: activation by physical stresses and phorbol ester derivatives through protein kinase C-dependent and-independent pathways. J Biol Chem 278:27129–27137

    Article  PubMed  CAS  Google Scholar 

  • Gong Z, Son W, Chung YD, Kim J, Shin DW, McClung CA, Lee Y, Lee HW, Chang DJ, Kaang BK, Cho H, Oh U, Hirsh J, Kernan MJ, Kim C (2004) Two interdependent TRPV channel subunits, inactive and Nanchung, mediate hearing in Drosophila. J Neurosci 24:9059–9066

    Article  PubMed  CAS  Google Scholar 

  • Gudermann T, Flockerzi V (2005) TRP channels as new pharmacological targets. Naunyn Schmiedebergs Arch Pharmacol 371:241–244

    Article  PubMed  CAS  Google Scholar 

  • Guler AD, Lee H, Iida T, Shimizu I, Tominaga M, Caterina M (2002) Heat-evoked activation of the ion channel, TRPV4. J Neurosci 22:6408–6414

    PubMed  CAS  Google Scholar 

  • Gunthorpe MJ, Benham CD, Randall A, Davis JB (2002) The diversity in the vanilloid (TRPV) receptor family of ion channels. Trends Pharmacol Sci 23:183–191

    Article  PubMed  CAS  Google Scholar 

  • Hardie RC, Minke B (1992) The trp gene is essential for a light-activated Ca2+ channel in Drosophila photoreceptors. Neuron 8:643–651

    Article  PubMed  CAS  Google Scholar 

  • Hoenderop JG, van der Kemp AW, Hartog A, van de Graaf SF, van Os CH, Willems PH, Bindels RJ (1999) Molecular identification of the apical Ca2+ channel in 1, 25-dihydroxy-vitamin D3-responsive epithelia. J Biol Chem 274:8375–8378

    Article  PubMed  CAS  Google Scholar 

  • Hoenderop JG, Nilius B, Bindels RJ (2003) Epithelial calcium channels: from identification to function and regulation. Pflugers Arch 446:304–308

    PubMed  CAS  Google Scholar 

  • Kanzaki M, Zhang YQ, Mashima H, Li L, Shibata H, Kojima I (1999) Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I. Nat Cell Biol 1:165–170

    Article  PubMed  CAS  Google Scholar 

  • Kaplan JM, Horvitz HR (1993) A dual mechanosensory and chemosensory neuron in Caenorhabditis elegans. Proc Natl Acad Sci U S A 90:2227–2231

    Article  PubMed  CAS  Google Scholar 

  • Kim J, Chung YD, Park DY, Choi S, Shin DW, Soh H, Lee HW, Son W, Yim J, Park CS, Kernan MJ, Kim C (2003) A TRPV family ion channel required for hearing in Drosophila. Nature 424:81–84

    Article  PubMed  CAS  Google Scholar 

  • Lazzeri M, Vannucchi MG, Zardo C, Spinelli M, Beneforti P, Turini D, Faussone-Pellegrini MS (2004) Immunohistochemical evidence of vanilloid receptor 1 in normal human urinary bladder. Eur Urol 46:792–798

    Article  PubMed  CAS  Google Scholar 

  • Lee H, Iida T, Mizuno A, Suzuki M, Caterina MJ (2005) Altered thermal selection behavior in mice lacking transient receptor potential vanilloid 4. J Neurosci 25:1304–1310

    Article  PubMed  CAS  Google Scholar 

  • Liedtke W, Friedman JM (2003) Abnormal osmotic regulation in trpv4-/- mice. Proc Natl Acad Sci U S A 100:13698–13703

    Article  PubMed  CAS  Google Scholar 

  • Liedtke W, Kim C (2005) Functionality of the TRPV subfamily of TRP ion channels: add mechano-TRP and osmo-TRP to the lexicon! Cell Mol Life Sci 62:2985–3001

    Article  PubMed  CAS  Google Scholar 

  • Liedtke W, Choe Y, Marti-Renom MA, Bell AM, Denis CS, Sali A, Hudspeth AJ, Friedman JM, Heller S (2000) Vanilloid receptor-related osmotically activated channel (VROAC), a candidate vertebrate osmoreceptor. Cell 103:525–535

    Article  PubMed  CAS  Google Scholar 

  • Liedtke W, Tobin DM, Bargmann CI, Friedman JM (2003) Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in C. elegans. Proc Natl Acad Sci U S A 100:14531–14536

    Article  PubMed  CAS  Google Scholar 

  • Liu X, Bandyopadhyay B, Nakamoto T, Singh B, Liedtke W, Melvin JE, Ambudkar I (2006) A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery. J Biol Chem 281:15485–15495

    Article  PubMed  CAS  Google Scholar 

  • Martinac B, Hamill OP (2002) Gramicidin A channels switch between stretch activation and stretch inactivation depending on bilayer thickness. Proc Natl Acad Sci U S A 99:4308–4312

    Article  PubMed  CAS  Google Scholar 

  • Mizuno A, Matsumoto N, Imai M, Suzuki M (2003) Impaired osmotic sensation in mice lacking TRPV4. Am J Physiol Cell Physiol 285:C96–101

    PubMed  CAS  Google Scholar 

  • Montell C, Rubin GM (1989) Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction. Neuron 2:1313–1323

    Article  PubMed  CAS  Google Scholar 

  • Muraki K, Iwata Y, Katanosaka Y, Ito T, Ohya S, Shigekawa M, Imaizumi Y (2003) TRPV2 is a component of osmotically sensitive cation channels in murine aortic myocytes. Circ Res 93:829–838

    Article  PubMed  CAS  Google Scholar 

  • Mutai H, Heller S (2003) Vertebrate and invertebrate TRPV-like mechanoreceptors. Cell Calcium 33:471–478

    Article  PubMed  CAS  Google Scholar 

  • Naeini RS, Witty MF, Seguela P, Bourque CW (2005) An N-terminal variant of Trpv1 channel is required for osmosensory transduction. Nat Neurosci 9:93–98

    Article  Google Scholar 

  • Nagata K, Duggan A, Kumar G, Garcia-Anoveros J (2005) Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing. J Neurosci 25:4052–4061

    Article  PubMed  CAS  Google Scholar 

  • Nilius B, Sage SO (2005) TRP channels: novel gating properties and physiological functions. J Physiol 567:33–34

    Article  CAS  Google Scholar 

  • Nilius B, Voets T, Peters J (2005) TRP channels in disease. Sci STKE 2005:re8

    Google Scholar 

  • Patapoutian A (2005) TRP channels and thermosensation. chem senses 30Suppl 1:i193–i194

    Article  PubMed  CAS  Google Scholar 

  • Peier AM, Reeve AJ, Andersson DA, Moqrich A, Earley TJ, Hergarden AC, Story GM, Colley S, Hogenesch JB, McIntyre P, Bevan S, Patapoutian A (2002) A heat-sensitive TRP channel expressed in keratinocytes. Science 296:2046–2049

    Article  PubMed  CAS  Google Scholar 

  • Peng JB, Chen XZ, Berger UV, Vassilev PM, Tsukaguchi H, Brown EM, Hediger MA (1999) Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption. J Biol Chem 274:22739–22746

    Article  PubMed  CAS  Google Scholar 

  • Peng JB, Brown EM, Hediger MA (2003) Epithelial Ca2+ entry channels: transcellular Ca2+ transport and beyond. J Physiol 551:729–740

    Article  PubMed  CAS  Google Scholar 

  • Pomonis JD, Harrison JE, Mark L, Bristol DR, Valenzano KJ, Walker K (2003) N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine-1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropathic pain. J Pharmacol Exp Ther 306:387–393

    Article  PubMed  CAS  Google Scholar 

  • Rong W, Hillsley K, Davis JB, Hicks G, Winchester WJ, Grundy D (2004) Jejunal afferent nerve sensitivity in wild-type and TRPV1 knockout mice. J Physiol 560:867–881

    Article  PubMed  CAS  Google Scholar 

  • Scotland RS, Chauhan S, Davis C, De Felipe C, Hunt S, Kabir J, Kotsonis P, Oh U, Ahluwalia A (2004) Vanilloid receptor TRPV1, sensory C-fibers, and vascular autoregulation: a novel mechanism involved in myogenic constriction. Circ Res 95:1027–1034

    Article  PubMed  CAS  Google Scholar 

  • Smith GD, Gunthorpe MJ, Kelsell RE, Hayes PD, Reilly P, Facer P, Wright JE, Jerman JC, Walhin JP, Ooi L, Egerton J, Charles KJ, Smart D, Randall AD, Anand P, Davis JB (2002) TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature 418:186–190

    Article  PubMed  CAS  Google Scholar 

  • Sokolchik I, Tanabe T, Baldi PF, Sze JY (2005) Polymodal sensory function of the Caenorhabditis elegans OCR-2 channel arises from distinct intrinsic determinants within the protein and is selectively conserved inmammalian TRPV proteins. J Neurosci 25:1015–1023

    Article  PubMed  CAS  Google Scholar 

  • Stein RJ, Santos S, Nagatomi J, Hayashi Y, Minnery BS, Xavier M, Patel AS, Nelson JB, Futrell WJ, Yoshimura N, Chancellor MB, De Miguel F (2004) Cool (TRPM8) and hot (TRPV1) receptors in the bladder and male genital tract. J Urol 172:1175–1178

    Article  PubMed  CAS  Google Scholar 

  • Strotmann R, Harteneck C, Nunnenmacher K, Schultz G, Plant TD (2000) OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol 2:695–702

    Article  PubMed  CAS  Google Scholar 

  • Suzuki M, Mizuno A, Kodaira K, Imai M (2003) Impaired pressure sensation in mice lacking TRPV4. J Biol Chem 278:22664–22668

    Article  PubMed  CAS  Google Scholar 

  • Tian W, Salanova M, Xu H, Lindsley JN, Oyama TT, Anderson S, Bachmann S, Cohen DM (2004) Renal expression of osmotically responsive cation channel TRPV4 is restricted to water-impermeant nephron segments. Am J Physiol Renal Physiol 287:F17–24

    Article  PubMed  Google Scholar 

  • Tobin D, Madsen DM, Kahn-Kirby A, Peckol E, Moulder G, Barstead R, Maricq AV, Bargmann CI (2002) Combinatorial expression of TRPV channel proteins defines their sensory functions and subcellular localization in C. elegans neurons. Neuron 35:307–318

    Article  PubMed  CAS  Google Scholar 

  • Todaka H, Taniguchi J, Satoh J, Mizuno A, Suzuki M (2004) Warm temperature-sensitive transient receptor potential vanilloid 4 (TRPV4) plays an essential role in thermal hyperalgesia. J Biol Chem 279:35133–35138

    Article  PubMed  CAS  Google Scholar 

  • Tominaga M, Caterina MJ (2004) Thermosensation and pain. J Neurobiol 61:3–12

    Article  PubMed  Google Scholar 

  • Vriens J, Watanabe H, Janssens A, Droogmans G, Voets T, Nilius B (2003) Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4. Proc Natl Acad Sci U S A 101:396–401

    Article  PubMed  Google Scholar 

  • Vriens J, Owsianik G, Voets T, Droogmans G, Nilius B (2004) Invertebrate TRP proteins as functional models for mammalian channels. Pflugers Arch 449:213–226

    PubMed  CAS  Google Scholar 

  • Walker RG, Willingham AT, Zuker CS (2000) A Drosophila mechanosensory transduction channel. Science 287:2229–2234

    Article  PubMed  CAS  Google Scholar 

  • Watanabe H, Vriens J, Suh SH, Benham CD, Droogmans G, Nilius B (2002) Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells. J Biol Chem 277:47044–47051

    Article  PubMed  CAS  Google Scholar 

  • Wissenbach U, Bodding M, Freichel M, Flockerzi V (2000) Trp12, a novel Trp related protein from kidney. FEBS Lett 485:127–134

    Article  PubMed  CAS  Google Scholar 

  • Wissenbach U, Niemeyer BA, Flockerzi V (2004) TRP channels as potential drug targets. Biol Cell 96:47–54

    Article  PubMed  CAS  Google Scholar 

  • Wong F, Schaefer EL, Roop BC, LaMendola JN, Johnson-Seaton D, Shao D (1989) Proper function of the Drosophila trp gene product during pupal development is important for normal visual transduction in the adult. Neuron 3:81–94

    Article  PubMed  CAS  Google Scholar 

  • Xu H, Ramsey IS, Kotecha SA, Moran MM, Chong JA, Lawson D, Ge P, Lilly J, Silos-Santiago I, Xie Y, DiStefano PS, Curtis R, Clapham DE (2002) TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature 418:181–186

    Article  PubMed  CAS  Google Scholar 

  • Xu H, Zhao H, Tian W, Yoshida K, Roullet JB, Cohen DM (2003) Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinasedependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. J Biol Chem 278:11520–11527

    Article  PubMed  CAS  Google Scholar 

  • Xu H, Fu Y, Tian W, Cohen DM (2005) Glycosylation of the osmoresponsive transient receptor potential channel TRPV4 on Asn-651 influences membrane trafficking. Am J Physiol Renal Physiol 290:F1103–F1109

    Article  PubMed  Google Scholar 

  • Xu XZ, Li HS, Guggino WB, Montell C (1997) Coassembly of TRP and TRPL produces a distinct store-operated conductance. Cell 89:1155–1164

    Article  PubMed  CAS  Google Scholar 

  • Xu XZ, Chien F, Butler A, Salkoff L, Montell C (2000) TRPgamma, a Drosophila TRP-related subunit, forms a regulated cation channel with TRPL. Neuron 26:647–657

    Article  PubMed  CAS  Google Scholar 

  • Zhang S, Sokolchik I, Blanco G, Sze JY (2004) Caenorhabditis elegans TRPV ion channel regulates 5HT biosynthesis in chemosensory neurons. Development 131:1629–1638

    Article  PubMed  CAS  Google Scholar 

  • Zhu X, Chu PB, Peyton M, Birnbaumer L (1995) Molecular cloning of a widely expressed human homologue for the Drosophila trp gene. FEBS Lett 373:193–198

    Article  PubMed  CAS  Google Scholar 

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  1. Center for Translational Neuroscience, Duke University, Durham, NC, 27710, USA

    W. Liedtke

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  1. Experimentele und Klinische, Pharmakologie und Toxikologie, Universität des Saarlandes, Gebäude 46, 66421, Homburg, Deutschland

    Veit Flockerzi

  2. Laboratorium voor Fysiologie, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, 3000, Leuven, België

    Bernd Nilius

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Liedtke, W. (2007). TRPV Channels’ Role in Osmotransduction and Mechanotransduction. In: Flockerzi, V., Nilius, B. (eds) Transient Receptor Potential (TRP) Channels. Handbook of Experimental Pharmacology, vol 179. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-34891-7_28

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