Abstract
Imaging is important in the differential diagnosis as well as in the assessment of functional constraints and therapy response in interstitial lung disease. Imaging has to address three main topics: (1) visualization and recognition of morphological changes and their patterns; (2) assessment of pulmonary function, i.e. restrictive ventilatory impairment, reduction of perfusion and gas exchange; and (3) assessment of inflammatory activity. MRI is capable to provide image-based answers to all three topics. Typical patterns, such as reticular and reticulonodular changes, ground glass, consolidation and honey-combing are easily visualized. Functional imaging using contrast-enhanced perfusion MRI and ventilation MRI with hyperpolarized gases or oxygen are available for the assessment of restrictive constraints. Routine contrast-enhanced MRI allows estimating inflammatory activity in different types of interstitial lung disease which is a clear advantage over CT which has limitations in this regard.
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References
Albert MS, Cates GD, Driehuys B et al. (1994) Biological mag-netic resonance imaging using laser-polarized 129Xe. Nature 370:199–201
Arnold JF, Kotas M, Fidler F et al. (2007) Quantitative regional oxygen transfer imaging of the human lung. J Magn Reson Imaging 26:637–645
Arroliga AC, Podell DN, Matthay RA (1992) Pulmonary manifestations of scleroderma. J Thorac Imag 7:30–45
ATS/ERS (2002) American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. Am J Respir Crit Care Med 165:277–304
Bankier AA, Kiener HP, Wiesmayr MN et al. (1995) Discrete lung involvement in systemic lupus erythematosus: CT assessment. Radiology 196:835–840
Bekkelund SI, Aasebo U, Pierre-Jerome C et al. (1998) Magnetic resonance imaging of the thorax in the evaluation of asbestosis. Eur Respir J 11:194–197
Berthezene Y, Vexler V, Kuwatsuru R et al. (1992) Differentiation of alveolitis and pulmonary fibrosis with a macromolecular MR imaging contrast agent. Radiology 185:97–103
Bink A, Hanisch G, Karg A et al. (2007) Clinical aspects of the apparent diffusion coefficient in 3He MRI: results in healthy volunteers and patients after lung transplantation. J Magn Reson Imaging 25:1152–1158
Black RD, Middleton HL, Cates GD et al. (1996) In vivo He-3 MR images of guinea pig lungs. Radiology 199:867–870
Chetta A, Marangio E, Olivieri D (2004) Pulmonary function testing in interstitial lung diseases. Respiration 71:209–213
Colby TV, Carrington CB (1994) Infiltrative lung disease. In: Thurlbeck WM (ed) Pathology of the lung. Thieme Medical Publishers, New York, pp 589–737
Craig DA, Colletti PM, Ratto D et al. (1988) MRI findings in pulmonary sarcoidosis. Magn Reson Imaging 6:567–573
Dawson WB, Müller NL (1990) High-resolution computed tomography in pulmonary sarcoidosis. Semin Ultra CT MR 11:423–429
Desai SR, Verraraghavan S, Hansell DM et al. (2004) CT features of lung disease in patients with systemic sclerosis: comparison with idiopathic pulmonary fibrosis and non-specific interstitial pneumonia. Radiology 232:560–567
Edelman RR, Hatabu H, Tadamura E et al. (1996) Noninvasive assessment of regional ventilation in the human lung using oxygen-enhanced magnetic resonance imaging. Nat Med 2:1236–1239
Fenlon HM, Doran M, Sant SM et al. (1996) High-resolution chest CT in systemic lupus erythematosus. AJR Am J Roentgenol 166:301–307
Gammon RB, Bridges TA, al-Nezir H et al. (1992) Bronchiolitis obliterans organizing pneumonia associated with systemic lupus erythematosus. Chest 102:1171–1174
Gast KK, Puderbach MU, Rodriguez I et al. (2003) Distribution of ventilation in lung transplant recipients: evaluation by dynamic 3He-MRI with lung motion correction. Invest Radiol 38:341–348
Gast KK, Biedermann A, Herweling A et al. (2007) Oxygen-sensitive (3)He-MRI in bronchiolitis obliterans after lung transplantation. Eur Radiol 18:530–537
Gibson GJ, Pride NB (1977) Pulmonary mechanics in fibrosing alveolitis: the effects of lung shrinkage. Am Rev Respir Dis 116:637–647
Glazer H, Levitt RG, Lee JK et al. (1984) Differentiation of radiation fibrosis from recurrent pulmonary neoplasm by magnetic resonance imaging. AJR Am J Roentgenol 143:729–730
Goodson BM (2002) Nuclear magnetic resonance of laser-polarized noble gases in molecules, materials, and organisms. J Magn Reson 155:157–216
Grenier P, Valeyre D, Cluzel P et al. (1991) Chronic diffuse interstitial lung disease: diagnostic value of chest radiography and high-resolution CT. Radiology 179:123–132
Gross TJ, Hunninghake GW (2001) Idiopathic pulmonary fibrosis. N Engl J Med 345:517–525
Guenther D, Hanisch G, Kauczor HU (2000) Functional MR imaging of pulmonary ventilation using hyperpolarized noble gases. Acta Radiol 41:519–528
Hughes JM (2003) The single breath transfer factor (Tl, co) and the transfer coefficient (Kco): a window onto the pulmonary microcirculation. Clin Physiol Funct Imaging 23:63–71
Hunninghake GW, Zimmerman MB, Schwartz DA et al. (2001) Utility of a lung biopsy for the diagnosis of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 164:193–196
Jakob PM, Hillenbrand CM, Wang T et al. (2001) Rapid quantitative lung (1)H T(1) mapping. J Magn Reson Imaging 14:795–799
Jakob PM, Wang T, Schultz G et al. (2004) Assessment of human pulmonary function using oxygen-enhanced T(1) imaging in patients with cystic fibrosis. Magn Reson Med 51:1009–1016
Kadota J, Kusano S, Kawakami K et al. (1995) Usual interstitial pneumonia associated with primary Sjögren’s syndrome. Chest 108:1756–1758
Kalaitzoglou I, Drevelengas A, Palladas P et al. (1998) MRI appearance of pulmonary Wegener’s granulomatosis with concomitant splenic infarction. Eur Radiol 8:367–370
Katzenstein AL, Fiorelli RF (1994) Nonspecific interstitial pneumonia/fibrosis: histologic features and clinical significance. Am J Surg Pathol 18:136–147
Katzenstein AL, Myers JL (1998). Idiopathic pulmonary fibrosis: clinical relevance of pathologic classification. Am J Respir Crit Care Med 157:1301–1315
Kauczor U, Kreitner KF (1999) MRI of the pulmonary parenchyma. Eur Radiol 9:1755–1764
Kauczor HU, Hofmann D, Kreitner KF et al. (1996) Normal and abnormal pulmonary ventilation: visualization at hyperpolarized He-3 MR imaging. Radiology 201:564–568
Kauczor HU, Chen XJ, van Beek EJ et al. (2001) Pulmonary ventilation imaged by magnetic resonance: at the doorstep of clinical application. Eur Respir J 17:1008–1023
Kauczor HU, Hanke A, Van Beek EJ (2002) Assessment of lung ventilation by MR imaging: current status and future perspectives. Eur Radiol 12:1962–1970
Kersjes W, Hildebrandt G, Cagil H et al. (1999) Differentiation of alveolitis and pulmonary fibrosis in rabbits with magnetic resonance imaging after intrabronchial administration of bleomycin. Invest Radiol 34:13–21
Kim JS, Lee KS, Koh EM et al. (2000) Thoracic involvement of systemic lupus erythematosus: clinical, pathologic, and radiologic findings. J Comput Assist Tomogr 24:9–18
Knudson RJ, Kaltenborn WT (1981) Evaluation of lung elastic recoil by exponential curve analysis. Respir Physiol 46:29–42
Kreider ME, Hansen-Flaschen J, Ahmad NN et al. (2007) Complications of video-assisted thoracoscopic lung biopsy in patients with interstitial lung disease. Ann Thorac Surg 83:1140–1144
Leung AN, Staples CA, Müller NL (1993) Parenchymal opacification in chronic infiltrative lung diseases: CT-pathologic correlation. Radiology 188:209–214
MacFall JR, Charles HC, Black RD et al. (1996) Human lung air spaces: potential for MR imaging with hyperpolarized He-3. Radiology 200:553–558
Markstaller K, Kauczor HU, Puderbach M et al. (2002) 3He-MRI-based vs. conventional determination of lung volumes in patients after unilateral lung transplantation: a new approach to regional spirometry. Acta Anaesthesiol Scand 46:845–852
Matsumoto S, Mori H, Miyake H et al. (1998) MRI signal characteristics of progressive massive fibrosis in silicosis. Clin Radiol 53:510–514
McAdams HP, Rosado-de-Christenson ML, Wehunt WD et al. (1996) The alphabet soup revisited: the chronic interstitial pneumonias in the 1990s. Radiographics 16:1009–1034
McCormack FX, King TE Jr, Voelker DR et al. (1991) Idiopathic pulmonary fibrosis. Abnormalities in the bronchoalveolar lavage content of surfactant protein A. Am Rev Respir Dis 144:160–166
McFadden R, Carr TJ, Wood TE (1987) Proton magnetic resonance imaging to stage activity of interstitial lung disease. Chest 92:31–39
Middleton H, Black RD, Saam B et al. (1995) MR imaging with hyperpolarized 3He gas. Magn Reson Med 33:271–5
Miller BH, Rosado-de-Christenson ML, McAdams HP et al. (1995) From the archives of the AFIP. Thoracic sarcoidosis: radiologic-pathologic correlation. Radiographics 15:421–437
Molinari F, Eichinger M, Risse F et al. (2007) Navigator-triggered oxygen-enhanced MRI with simultaneous cardiac and respiratory synchronization for the assessment of interstitial lung disease. J Magn Reson Imaging 26:1523–1529
Moller HE, Chen XJ, Saam B et al. (2002) MRI of the lungs using hyperpolarized noble gases. Magn Reson Med 47:1029–1051
Müller N, Mayo JR, Zwirewich CV (1992) Value of MR imaging in the evaluation of chronic infiltrative lung disease: comparison with CT. AJR Am J Roentgenol 158:1205–1209
Muller CJ, Schwaiblmair M, Scheidler J et al. (2002) Pulmonary diffusing capacity: assessment with oxygen-enhanced lung MR imaging preliminary findings. Radiology 222:499–506
Ohno Y, Hatabu H, Takenaka D et al. (2002) Dynamic oxygen-enhanced MRI reflects diffusing capacity of the lung. Magn Reson Med 47:1139–1144
Perez T, Remy-Jardin M, Cortet B (1998) Airways involvement in rheumatoid arthritis: clinical, functional, and HRCT findings. Am J Respir Crit Care Med 157:1658–1665
Primack S, Mayo JR, Hartman TE et al. (1994) MRI of infiltrative lung disease: comparison with pathologic findings. J Comput Assist Tomogr 18:233–238
Puderbach M, Hintze C, Ley S et al. (2007) MR imaging of the chest: a practical approach at 1.5T. Eur J Radiol 64:345–355
Remy-Jardin M, Remy J, Cortet B et al. (1994) Lung changes in rheumatoid arthritis: CT findings. Radiology 193:375–382
Sant SM, Doran M, Fenelon HM et al. (1997) Pleuropulmonary abnormalities in patients who have systemic lupus erythematosus: assessment with high resolution computed tomography, chest radiography and pulmonary function tests. Clin Exp Rheumatol 15:507–513
Shioya S, Haida M, Fukuzaki M et al. (1990) A 1-year time course study of the relaxation times and histology for irradiated rat lungs. Magn Reson Med 14:358–368
Taorimina VJ (1981) Progressive systemic sclerosis subgroups: variable pulmonary features. AJR Am J Roentgenol 137:277–285
Taylor CR, Sostman HD, Gore JC et al. (1987) Proton relaxation times in bleomycin-induced lung injury. Invest Radiol 22:621–626
Terriff BA, Kwan SY, Chan-Yeung MM et al. (1992) Fibrosing alveolitis: chest radiography and CT as predictors of clinical and functional impairment at follow-up in 26 patients. Radiology 184:445–449
Thompson MJ, Colebatch HJ (1989) Decreased pulmonary distensibility in fibrosing alveolitis and its relation to decreased lung volume. Thorax 44:725–731
Ulmer WT, Gillissen A, Reichel G et al. (1993) Lung function and normal values [in German]. Pneumologie 47:403–408
Vinitski S, Pearson MG, Karlik SJ et al. (1986) Differentiation of parenchymal lung disorders with in vitro proton nuclear magnetic resonance. Magn Reson Med 3:120–125
Webb WR (2001) Sarcoidosis. In: Webb WR, Müller NL, Naidich DP (eds) High-resolution CT of the lungs. Lippincott William and Wilkins, Philadelphia, pp 286–303
Webb WR, Stein MG, Finkbeiner WE et al. (1988) Normal and diseased isolated lungs: high-resolution CT. Radiology 166:81–87
Wells AU, Hogaboam CM (2007) Update in diffuse parenchymal lung disease 2006. Am J Respir Crit Care Med 175:655–660
Wells AU, Rubens MB, du Bois RM et al. (1993) Serial CT in fibrosing alveolitis: prognostic significance of the initial pattern. AJR Am J Roentgenol 161:1159–1165
Wiedemann HP, Matthay RA (1992) Pulmonary manifestations of systemic lupus erythematosus. J Thorac Imaging 7:1–18
Yankelevitz D, Henschke CI, Batata M et al. (1994) Lung cancer: evaluation with MR imaging during and after irradiation. J Thorac Imaging 9:41–46
Zaporozhan J, Ley S, Gast KK et al. (2004) Functional analysis in single-lung transplant recipients: a comparative study of high-resolution CT, 3He-MRI, and pulmonary function tests. Chest 125:173–181
Zaporozhan J, Ley S, Gast KK et al. (2005) [Visual assessment of functional lungs parenchyma on HRCT and (3)He-MRI in patients after single lung transplantation: comparison with quantitative volumetric results]. Fortschr Röntgenstr 177:516–523
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Marten, K., Molinari, F. (2009). Interstitial Lung Disease. In: Kauczor, HU. (eds) MRI of the Lung. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-34619-7_14
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DOI: https://doi.org/10.1007/978-3-540-34619-7_14
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