Mouse Models of Acute Promyelocytic Leukemia

  • S. C. Kogan
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 313)


Mouse models of acute promyelocytic leukemia have been generated through transgenic, knock-in, retroviral, and xenograft strategies. These models have been used to elucidate mechanisms underlying leukemogenesis. Among the areas investigated are the role of reciprocal fusions; effects of target cells, expression levels, and mouse strains; cooperating events; and restrictive and permissive factors. These models have also been used to gain insight into the effects of the immune system on leukemic cells and the mechanism of response to retinoic acid. Furthermore, preclinical studies utilizing these mice have advanced therapy for myeloid leukemia.


Acute Myeloid Leukemia Acute Promyelocytic Leukemia Neutrophil Elastase Histone Deacetylase Inhibitor Arsenic Trioxide 
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© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • S. C. Kogan
    • 1
  1. 1.Department of Laboratory Medicine and Comprehensive Cancer CenterUniversity of California, San FranciscoSan FranciscoUSA

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