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Arzneiverordnungs-Report 2006 pp 709–734Cite as

Magen-Darm-Mittel und Laxantien

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Bedeutsamste Gruppe der Magen-Darm-Mittel sind unverändert die Protonen-pumpenhemmer zur Behandlung der Refluxkrankheit und zur Prophylaxe und Therapie der Magen-Duodenalulzera. Nach wie vor zweitgrößte Gruppe, aber in deutlichem Abstand der Verordnungen, sind die H2-Rezeptorenblocker. Gering zugenommen hat die Verordnung von motilitätssteigernden Mitteln und Medikamenten gegen chronisch-entzündliche Darmkrankheiten. Kleinere Verordnungsvolumen entfallen auf Laxantien, auf Antidiarrhoika und Pankreasenzyme.

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Literatur

  • Updated Guidelines des American College of Gastroenterology for the diagnosis and treatment of gastroesophageal reflux disease (American Journal of Gastroenterology 100: 190–200, 2005)

    Article  Google Scholar 

  • Arzneimittelkommission der deutschen Ärzteschaft (2006): Arzneiverordnungen. Empfehlungen zur rationalen Pharmakotherapie. 21. Auflage, Deutscher Ärzte-Verlag Köln, S. 907–921.

    Google Scholar 

  • Beker JA, Bianchi Porro G, Bigard MA, Delle Fave G, Devis G, Gouerou H, Maier C (1995): Double-blind comparison of pantoprazole and omeprazole for the treatment of acute duodenal ulcer. Eur J Gastroenterol Hepatol 7: 407–410.

    PubMed  CAS  Google Scholar 

  • Bleichner G, Bléhaut H, Mentec H, Moyse D (1997): Saccharomyces boulardii prevents diarrhea in critically ill tube-fed patients. Intensive Care Med 23: 517–523.

    Article  PubMed  CAS  Google Scholar 

  • Bombardier C, Laine L, Reicin A et al (2000): Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. N Engl J Med 343: 1520–1528.

    Article  PubMed  CAS  Google Scholar 

  • Bouras EP, Scolapio JS (2004): Gastric motility disorders: management that optimizes nutritional status. J Clin Gastroenterol 38: 549–557.

    Article  PubMed  Google Scholar 

  • Caspary WF, Lüpke NP, Oldiges FJ, Wahle K (1995): Diarrhoe in der ärztlichen Praxis. Münch Med Wochenschr 137: 411–415.

    Google Scholar 

  • Catalano F, Branciforte G, Catanzaro R, Bentivegna C, Cipolla R, Nuciforo G, Brogna A (1999): Comparative treatment of Helicobacter pylori-positive duodenal ulcer using pantoprazole at low and high doses versus omeprazole in triple therapy. Helicobacter 4: 178–184.

    Article  PubMed  CAS  Google Scholar 

  • Cetina-Sauri G., Basto G.S. (1991): Antidiarrhöische Therapie bei Kindern. Der Kinderarzt 22: 2059–2061.

    Google Scholar 

  • Chan FK, Hung LC, Suen BY, Wu JC, Lee KC, Leung VK, Hui AJ, To KF, Leung WK, Wong VW, Chung SC, Sung JJ (2002): Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis. N Engl J Med 347: 2104–2110.

    Article  PubMed  CAS  Google Scholar 

  • Chan FK, Ching JY, Hung LC, Wong VW, Leung VK, Kung NN, Hui AJ, Wu JC, Leung WK, Lee VW, Lee KK, Lee YT, Lau JY, To KF, Chan HL, Chung SC, Sung JJ (2005): Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. N Engl J Med 352: 238–244.

    Article  PubMed  CAS  Google Scholar 

  • Corinaldesi R, Valentini M, Belaiche J, Colin R, Geldof H, Maier C (1995): Pantoprazole and omeprazole in the treatment of reflux oesophagitis: a European multicentre study. Aliment Pharmacol Ther 9: 667–671.

    Article  PubMed  CAS  Google Scholar 

  • DeVault KR, Castell DO; American College of Gastroenterology (2005): Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Am J Gastroenterol 100: 190–200.

    Article  PubMed  Google Scholar 

  • Ellenrieder V, Boeck W, Richter C, Marre R, Adler G, Glasbrenner B (1999): Prevalence of resistance to clarithromycin and its clinical impact on the efficacy of Helicobacter pylori eradication. Scand J Gastroenterol 34: 750–756.

    Article  PubMed  CAS  Google Scholar 

  • Gionchetti P, Rizzello F, Helwig U, Venturi A, Lamers KM et al (2003): Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial. Gastroenterology 124: 1202–1209.

    Article  PubMed  Google Scholar 

  • Gionchetti P, Rizzello F, Venturi A, Brigidi P, Matteuzzi D, Bazzocchi G et al (2000): Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial. Gastroenterology 119: 305–309.

    Article  PubMed  CAS  Google Scholar 

  • Guarner F, Malagelada JR (2003): Gut flora in health and disease. Lancet 361: 512–519.

    Article  PubMed  Google Scholar 

  • Hawkey CJ, Karrasch JA, Szczepanski L, Walter DG, Barkun A et al (1998): Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group. N Engl J Med 338: 727–734.

    Article  PubMed  CAS  Google Scholar 

  • Hellers G, Cortot A, Jewell D et al (1999): Oral budesonide for prevention of postsurgical recurrence in Crohn’s disease. Gastroenterology 116: 294–300.

    Article  PubMed  CAS  Google Scholar 

  • Höchter W, Chase D, Hagenhoff G (1990): Saccharomyces boulardii bei akuter Erwachsenendiarrhoe. Wirksamkeit und Verträglichkeit der Behandlung. Münch Med Wochenschr 132: 188–192.

    Google Scholar 

  • Hoffmann, RM, Kruis W (2002): Probiotika und Präbiotika-eine Renaissance? Internist 43: 1400–1406.

    Article  PubMed  CAS  Google Scholar 

  • Kark W, Krebs-Richter H, Hotz J (1995): Improving the effect of orthograde colonic lavage with golytely solution by adding dimethicone. Z Gastroenterol 33: 20–23.

    PubMed  CAS  Google Scholar 

  • Koletzko S (1997): Sonstige Erkrankungen des Magen-Darm-Traktes. In: Reinhardt D (Hrsg): Therapie der Krankheiten im Kindes-und Jugendalter. 6.Aufl., Springer, Berlin Heidelberg New York, S. 759–776.

    Google Scholar 

  • Kollaritsch H, Holst H, Grobara P, Wiedermann G (1993): Prophylaxe der Reisediarrhöe mit Saccharomyces boulardii. Fortschr Med 111: 152–156.

    PubMed  CAS  Google Scholar 

  • Koop H, Schepp W, Muller-Lissner S, Madisch A, Micklefield G, Messmann H, Fuchs KH, Hotz J (2005): Gastroösophageale Refluxkrankheit-Ergebnisse einer evidenzbasierten Konsensuskonferenz der Deutschen Gesellschaft für Verdauungs-und Stoffwechselkrankheiten. Z Gastroenterol 43: 165–194.

    Article  Google Scholar 

  • Körner T, Schutze K, van Leendert RJ, Fumagalli I, Costa Neves B, Bohuschke M, Gatz G (2003): Comparable efficacy of pantoprazole and omeprazole in patients with moderate to severe reflux esophagitis. Results of a multinational study. Digestion 67: 6–13.

    PubMed  Google Scholar 

  • Kruis W, Schütz E, Fric P, Judmaier G, Stolte M (1997): Double-blind comparison of an oral Escherichia coli preparation and mesalazine in maintaining remission of ulcerative Colitis. Aliment Pharmacol Ther 11: 853–858.

    Article  PubMed  CAS  Google Scholar 

  • Labenz J, Armstrong D, Lauritsen K, Katelaris P, Schmidt S, Schutze K, Wallner G, Juergens H, Preiksaitis H, Keeling N, Naucler E, Adler J, Eklund S (2005): Esomeprazole 20 mg vs. pantoprazole 20 mg for maintenance therapy of healed erosive oesophagitis: results from the EXPO study. Aliment Pharmacol Ther 22: 803–811.

    Article  PubMed  CAS  Google Scholar 

  • Labenz J, Tillenburg B, Peitz U, Köhl H, Becker T et al (1996): Ulcusheilung durch Helicobacter-pylori-Eradikation: Genügt eine Woche Therapie? Dtsch Med Wochenschr 121: 3–8.

    Article  PubMed  CAS  Google Scholar 

  • Lee JM, Breslin NP, Hyde DK, Buckley MJ, O’Morain CA (1999): Treatment options for Helicobacter pylori infection when proton pump inhibitor-based triple therapy fails in clinical practice. Aliment Pharmacol Ther 13: 489–496.

    Article  PubMed  CAS  Google Scholar 

  • Lind T, Mégraud F, Unge P, Bayerdörffer E, O’Morain C, Spiller R, van Zenten S et al (1999): The MACH 2 study: Role of omeprazole in eradication of Helicobacter pylori with I-week triple therapies. Gastroenterology 116: 248–253.

    Article  PubMed  CAS  Google Scholar 

  • Lüth S, Teyssen S, Kölbel CB, Singer MV (2001): 4 day triple therapy with rabeprazole, amoxicillin and clarithromycin in the eradication of Helicobacter pylori in patients with peptic ulcer disease. Z Gastroenterol 39: 279–285.

    Article  PubMed  Google Scholar 

  • Malchow H A (1997): Crohn’s disease and Escherichia coli. A new approach in therapy to maintain remission of colonic Crohn’s disease? J Clin Gastroenteraol 25: 653–658.

    Article  CAS  Google Scholar 

  • Malfertheiner P, Mössner J, Fischbach W, Layer P, Leodolter A, Stolte M, Demleitner K, Fuchs W (2003): Helicobacter pylori eradication is beneficial in the treatment of functional dyspepsia. Aliment Pharmacol Ther 18: 615–625.

    Article  PubMed  CAS  Google Scholar 

  • McFarland LV, Surawicz CM, Greenberg RN (1994): A randomized placebo-controlled trial of saccharomyces boulardii in combination with standard antibiotics for clostridium difficile disease. JAMA 271: 1913–1918.

    Article  PubMed  CAS  Google Scholar 

  • Metcalf TJ, Irons TG, Sher LD, Young PC (1994): Simethicone in the treatment of infant colic: a randomized placebo-controlled multicenter trial. Pediatrics 94: 29–34.

    PubMed  CAS  Google Scholar 

  • Mössner J, Hölscher AH, Herz R, Schneider A (1995): A double-blind study of pantoprazole and omeprazole in the treatment of reflux oesophagitis: a multicentre trial. Aliment Pharmacol Ther 9: 321–326.

    Article  PubMed  Google Scholar 

  • Mulder CJ, Westerveld BD, Smit JM, Oudkerk Pool M, Otten MH, Tan TG, van Milligen de Wit AW, de Groot GH; Dutch omeprazole MUPS study group (2002): A double-blind, randomized comparison of omeprazole Multiple Unit Pellet System (MUPS) 20mg, lansoprazole 30 mg and pantoprazole 40 mg in symptomatic reflux oesophagitis followed by 3 months of omeprazole MUPS maintenance treatment: a Dutch multicentre trial. Eur J Gastroenterol Hepatol 14: 649–656.

    Article  PubMed  CAS  Google Scholar 

  • National Institute for Clinical Excellence (2004): Dyspepsia: management of dyspepsia in adults in primary care. Clinical Guideline 17. Internet: www.nice.org.uk/page.aspx?o=CG017NICEguideline

    Google Scholar 

  • Rehner M, Rohner HG, Schepp W (1995): Comparison of pantoprazole versus omeprazole in the treatment of acute duodenal ulceration-a multicentre study. Aliment Pharmacol Ther 9: 411–416.

    Article  PubMed  CAS  Google Scholar 

  • Rembacken BJ, Snelling AM, Hawkey PM, Chalmers DM, Axon ATR (1999): Non pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial. Lancet 354: 635–639.

    Article  PubMed  CAS  Google Scholar 

  • Richter JE, Bochenek W (2000): Oral pantoprazole for erosive esophagitis: a placebo-controlled, randomized clinical trial. Pantoprazole US GERD Study Group. Am J Gastroenterol 95: 3071–3080.

    Article  PubMed  CAS  Google Scholar 

  • Rutgeerts P, Löfberg R, Malchow H et al (1994): A comparison of budesonide with prednisolone for active Crohn’s disease. N Engl J Med 331: 842–845.

    Article  PubMed  CAS  Google Scholar 

  • Scarpignato C, Rampal P (1995): Prevention and treatment of traveler’s diarrhea: a clinical pharmacological approach. Chemotherapy 41(Suppl 1): 48–81.

    Article  PubMed  Google Scholar 

  • Smith DS, Ferris CD (2003): Current concepts in diabetic gastroparesis. Drugs 63: 1339–1358.

    Article  PubMed  Google Scholar 

  • Stange EF, Riemann J, von Herbay A, Lochs H, Fleig WE, Scholmerich J et al (2001): Diagnostik und Therapie der Colitis ulcerosa-Ergebnisse einer evidenzbasierten Konsensuskonferenz der Deutschen Gesellschaft für Verdauungs-und Stoffwechselkrankheiten. Z Gastroenterol 39: 19–70.

    Article  PubMed  CAS  Google Scholar 

  • Stedman CA, Barclay ML (2000): Review article: comparison of the pharmacokinetics, acid suppression and efficacy of proton pump inhibitors. Aliment Pharmacol Ther 14: 963–978.

    Article  PubMed  CAS  Google Scholar 

  • Sudduth RH, DeAngelis S, Sherman KE, McNally PR (1995): The effectiveness of simethicone in improving visibility during colonoscopy when given with a sodium phosphate solution: a double-bind randomized study. Gastrointest Endosc 42: 413–415.

    Article  PubMed  CAS  Google Scholar 

  • Talley NJ, Vakil N, Baillard ED, Fennerty BM (1999): Absence of benefit of eradicating helicobacter pylori in patients with nonulcer dyspepsia. N Engl J Med 341: 1106–1111.

    Article  PubMed  CAS  Google Scholar 

  • Uemura N, Okamoto S, Yamamoto S, Matsumura N, Yamaguchi S, Yamakido M et al (2001): Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 345: 784–789.

    Article  PubMed  CAS  Google Scholar 

  • Vcev A, Stimac D, Vceva A, Takac B, Ivandic A, Pezerovic D, Horvat D, Nedic P, Kotromanovic Z, Maksimovic Z, Vranjes Z, Males J, Jurisic-Orzen D, Vladika I, Stimac T, Mandic B (1999): Pantoprazole versus omeprazole in the treatment of reflux esophagitis. Acta Med Croatica 53: 79–82.

    PubMed  CAS  Google Scholar 

  • Witzel L, Gutz H, Huttemann W, Schepp W (1995): Pantoprazole versus omeprazole in the treatment of acute gastric ulcers. Aliment Pharmacol Ther 9: 19–24.

    Article  PubMed  CAS  Google Scholar 

  • Wolfe MM, Lichtenstein DR (1999): Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N Engl J Med 340: 1888–1899.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Medizinische Klinik und Poliklinik II, Universität Leipzig, Philipp-Rosenthal-Straße 27, 04103, Leipzig

    Prof. Dr. med. Joachim Mössner

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  1. Prof. Dr. med. Joachim Mössner
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Editors and Affiliations

  1. Pharmakologisches Institut, Universität Heidelberg, Im Neuenheimer Feld 366, 69120, Heidelberg

    Ulrich Schwabe

  2. Bachstraße 29, 50858, Köln

    Dieter Paffrath

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Mössner, J. (2007). Magen-Darm-Mittel und Laxantien. In: Schwabe, U., Paffrath, D. (eds) Arzneiverordnungs-Report 2006. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-34370-7_35

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  • DOI: https://doi.org/10.1007/978-3-540-34370-7_35

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