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Adrenergic and Cholinergic Compounds

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Book cover Analgesia

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 177))

Abstract

Adrenergic and cholinergic signalling contributes significantly to the endogenous antinociceptive system. Exogenous α2 adrenergic agonists have a well-established analgesic profile; however, recent investigations suggest that this class of agents is underused, and herein we highlight the potential for both current application and future development of these agents. Nicotinic and muscarinic cholinergic ligands represent a novel class of agents with much promise for the management of problematic pain. In this chapter we review advances in both preclinical and clinical arenas and highlight potential avenues for further research.

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Authors and Affiliations

  1. Academic Anaesthetics, Imperial College, Chelsea and Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK

    R. D. Sanders & M. Maze

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  1. R. D. Sanders
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  2. M. Maze
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Correspondence to M. Maze .

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  1. Department of Anesthesiology and Critical Care Medicine Charité — Campus Benjamin Franklin, Free University Berlin, Hindenburgdamm 30, 12200, Berlin, Germany

    Christoph Stein

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Sanders, R.D., Maze, M. (2006). Adrenergic and Cholinergic Compounds. In: Stein, C. (eds) Analgesia. Handbook of Experimental Pharmacology, vol 177. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-33823-9_9

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