Abstract
Capillary hemangioma is the commonest childhood orbital vascular anomaly, usually presents as a painless swelling or vascular marking of the eyelids, and typically enlarges in infancy before undergoing spontaneous regression during childhood [8, 24]. Most periorbital hemangiomas pose no threat to visual development, but larger lesions may result in amblyopia due to mechanical ptosis, induced astigmatism, or displacement of the globe (Figs. 6.1, 6.2).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aldave AJ, Shields CL, Shields JA (1999) Surgical excision of selected amblyogenic periorbital capillary hemangiomas. Ophthalmic Surg Lasers 30:754–757
Antaya RJ (2002) Infantile hemangioma. In: Ortone JP, et al. (eds) eMedicine dermatology. eMedicine Corp, St. Petersburg. Available at: http://www.emedicine.com/derm/topic201.htm
Bauland CG, van Steensel MA, Steijlen PM, et al. (2006) The pathogenesis of hemangiomas: a review. Plast Reconstr Surg 117:29e–35e
Bree AF, Siegfreid E, Sotelo-Avila C, et al. (2001) Infantile haemangiomas: speculation on placental trophoblastic origin. Arch Dermatol 137:573–577
Bruckner AL, Frieden IJ (2003) Hemangiomas of infancy. J Am Acad Dermatol 48:477–493
Burstein FD, Simms C, Cohen SR, et al. (2000) Intralesional laser therapy of extensive hemangiomas in 100 consecutive pediatric patients. Ann Plast Surg 44:188–194
Burton BK, Schulz CJ, Angle B, et al. (1995) An increased incidence of hemangiomas in infants born following chorionic villus sampling (CVS). Prenat Diagn 15:209–214
Castillo BV Jr, Kaufman L (2003) Pediatric tumors of the eye and orbit. Pediatr Clin North Am 50:149–172
Chang J, Most D, Bresnick S, et al. (1999) Proliferative haemangiomas: analysis of cytokine gene expression and angiogenesis. Plast Reconstr Surg 103:1–9
Chau A, Fung K, Yip L, et al. (2004) Orbital development in Hong Kong Chinese subjects. Ophthalmic Physiol Opt 24:436–439
Clark DE, Smith SK, He Y, et al. (1998) A vascular endothelial growth factor antagonist is produced by the human placenta and released into the maternal circulation. Biol Reprod 59:1540–1548
Coats DK, O’Neil JW, D’Elia VJ, et al. (2003) Sub-Tenon’s infusion of steroids for treatment of orbital hemangiomas. Ophthalmology 110:1255–1259
Cogen MS, Elsas FJ (1989) Eyelid depigmentation following corticosteroid injection for infantile ocuÂlar adnexal hemangioma. J Pediatr Ophthalmol Strabismus 26:35–38
Dadras SS, North PE, Bertoncini J, et al. (2004) Infantile haemangiomas are arrested in an early developmental vascular differentiation state. Mod Pathol 17:1068–1079
Delesalle F, Staumont D, Houmany MA, et al. (2006) Pulse methylprednisolone therapy for threatening periocular haemangiomas of infancy. Acta Derm Venereol 86:429–432
Droste PJ, Ellis FD, Sondhi N, et al. (1988) Linear subcutaneous fat atrophy after corticosteroid injection of periocular hemangiomas. Am J Ophthalmol 105:56–59
Egbert JE, Schwartz GS, Walsh AW (1996) Diagnosis and treatment of an ophthalmic artery occlusion during an intralesional injection of corticosteroid into an eyelid capillary hemangioma. Am J Ophthalmol 121:638–642
Egbert JE, Paul S, Engel WK, et al. (2001) High injection pressure during intralesional injection of corticosteroids into capillary hemangiomas. Arch Ophthalmol 119:677–683
Elsas FJ, Lewis AR (1994) Topical treatment of periocular capillary hemangioma. J Pediatr Ophthalmol Strabismus 31:153–156
Fledelius HC, Illum N, Jensen H, et al. (2001) Interferon-alfa treatment of facial infantile haemangiomas: with emphasis on the sight-threatening varieties. A clinical series. Acta Ophthalmol Scand 79:370–373
Folkman J (1995) Clinical application of research on angiogenesis. N Engl J Med 333:1757–1763
Glowacki J, Mulliken JB (1982) Mast cells in hemangiomas and vascular malformations. Pediatrics 70:48–51
Goyal R, Watts P, Lane CM, et al. (2004) Adrenal suppression and failure to thrive after steroid injections for periocular hemangioma. Ophthalmology 111:389–395
Haik BG, Karcioglu ZA, Gordon RA, et al. (1994) Capillary haemangioma (infantile periocular haemangioma). Surv Ophthalmol 38:399–426
Hasan Q, Tan ST, Xu B, Davis PF (2003) Effects of five commonly used glucocorticoids on haemangioma in vitro. Clin Exp Pharmacol Physiol 30:140–144
Hastings MM, Milot J, Barsoum-Homsy M, et al. (1997) Recombinant interferon alfa-2b in the treatment of vision-threatening capillary hemangiomas in childhood. J AAPOS 1:226–230
Jiang XW, Wang GH, Li JH, et al. (2005) Expression of glucocorticoid receptor isoforms in cutaneous hemangiomas and vascular malformations. Chin Med J (Engl) 118:977–981
Kräling BM, Razon MJ, Boon L, et al. (1996) E-selectin is present in proliferating endothelial cells in human hemangiomas. Am J Pathol 148:1181–1191
Nauck M, Karakiulakis G, Perruchoud AP, et al. (1998) Corticosteroids inhibit the expression of the vascular endothelial growth factor gene in human vascular smooth muscle cells. Eur J Pharmacol 341:309–315
Neudorfer M, Leibovitch I, Stolovitch C, et al. (2004) Intraorbital and periorbital tumors in children – value of ultrasound and color Doppler imaging in the differential diagnosis. Am J Ophthalmol 137:1065–1072
Neumann D, Isenberg SJ, Rosenbaum AL, et al. (1997) Ultrasonographically guided injection of corticosteroids for the treatment of retroseptal capillary hemangiomas in infants. J AAPOS 1:34–40
North PE, Waner M, Mizeracki A, et al. (2000) GLUT1: a newly discovered immunohistochemical marker for juvenile hemangiomas. Hum Pathol 31:11–22
North PE, Waner M, Mizeracki A, et al. (2001) A unique microvascular phenotype shared by juvenile hemangiomas and human placenta. Arch Dermatol 137:559–570
O’Keefe M, Lanigan B, Byrne SA (2003) Capillary haemangioma of the eyelids and orbit: a clinical review of the safety and efficacy of intralesional steroid. Acta Ophthalmol Scand 81:294–298
Plager DA, Snyder SK (1997) Resolution of astigmatism after surgical resection of capillary haemangiomas in infants. Ophthalmology 104:1102–1106
Ranchod TM, Frieden IJ, Fredrick DR (2005) Corticosteroid treatment of periorbital haemangioma of infancy: a review of the evidence. Br J Ophthalmol 89:1134–1138
Richtig E, Langmann G, Mullner K, et al. (2004) Calculated tumour volume as a prognostic parÂaÂmeter for survival in choroidal melanomas. Eye 18:619–623
Ritter MR, Dorrell MI, Edmonds J, et al. (2002) Insulin-like growth factor 2 and potential regulators of hemangioma growth and involution identified by large-scale expression analysis. Proc Natl Acad Sci USA 99:7455–7460
Slaughter K, Sullivan T, Boulton J, et al. (2003) Early surgical intervention as definitive treatment for ocular adnexal capillary haemangioma. Clin Exp Ophthalmol 31:418–423
Sleep TJ, Fairhurst JJ, Manners RM, et al. (2002) Doppler ultrasonography to aid diagnosis of orbital capillary haemangioma in neonates. Eye 16:316–319
Sutula FC, Glover AT (1987) Eyelid necrosis following intralesional corticosteroid injection for capillary hemangioma. Ophthalmic Surg 18:103–105
Verity DH, Restori M, Rose GE (2006) The natural history of periocular capillary haemangiomas: changes in internal blood velocity and lesion volume. Eye 20:1228–1237
Verma K, Verma KK (2001) Infantile periocular haemangioma treated with two days in a week betamethasone oral mini pulse therapy. Indian J Pediatr 68:355–356
Walker RS, Custer PL, Nerad JA (1994) Surgical excision of periorbital capillary hemangiomas. Ophthalmology 101:1333–1340
Waner M, Suen JY (1999) Treatment options for the management of hemangiomas. In: Waner M, Suen JY (eds) Hemangiomas and vascular malformations of the head and neck. Wiley-Liss, New York, pp 233–261
Wasserman BN, Medow NB, Homa-Palladino M, et al. (2004) Treatment of periocular capillary hemangiomas. J AAPOS 8:175–181
Yu Y, Varghese J, Brown LF, et al. (2001) Increased TIE2 expression, enhanced response to angiopoietin-1, and dysregulated angiopoietin-2 expression in hemangioma-derived endothelial cells. Am J Pathol 159:2271–2280
Yu Y, Fuhr J, Boye E, Gyorffy S, et al. (2006) Mesenchymal stem cells and adipogenesis in hemangioma involution. Stem Cells 24:1605–1612
Editor information
Rights and permissions
Copyright information
© 2007 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
(2007). Periocular Capillary Hemangioma: New Concepts in Natural History and Response to Glucocorticoids. In: Guthoff, R., Katowitz, J. (eds) Oculoplastics and Orbit. Essentials in Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-33677-8_6
Download citation
DOI: https://doi.org/10.1007/978-3-540-33677-8_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-33675-4
Online ISBN: 978-3-540-33677-8
eBook Packages: MedicineMedicine (R0)