8.10 Conclusions
Although no randomized, prospective studies have been performed, evidence suggests that in general uveal tumor biopsy with the 25-gauge vitreous cutter produces a larger sample than FNAB and more quickly and safely than transscleral incisional biopsy or using the 20-gauge vitrectomy system. Early results are encouraging, but it is likely that results will improve with further refinements of the technique and developments in laboratory methods.
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References
Damato B. Ocular tumours: Diagnosis and Treatment. Oxford: Butterworth Heinemann, 2000, pp 57–93.
Char DH, Kemlitz AE, Miller T. Intraocular biopsy. Ophthalmol. Clin. North Am. 2005;18:177–185.
Glasgow BJ, Brown HH, Zargoza AM, et al. Quantitation of tumor seeding from fine needle aspiration of ocular melanomas. Am. J. Ophthalmol. 1988;105:538–546.
Midena E, Segato T, Piermarocchi S, et al. Fine needle aspiration biopsy in ophthalmology. Surv. Ophthalmol. 1985;29:410–422.
Cohen VM, Dinakaran S, Parsons MA, et al. Transvitreal fine needle aspiration biopsy: the influence of intraocular lesion size on diagnostic biopsy result. Eye 2001;15:143–147.
Augsburger JJ, Correa ZM, Schneider S, et al. Diagnostic transvitreal fine-needle aspiration biopsy of small melanocytic choroidal tumors in nevus versus melanoma category. Trans. Am. Ophthalmol. Soc. 2002;100:225–232; discussion 232–234.
Shields JA, Shields CL, Ehya H, et al. Fine-needle aspiration biopsy of suspected intraocular tumors. The 1992 Urwick Lecture. Ophthalmology 1993;100:1677–1684.
Grossniklaus HE. Fine-needle aspiration biopsy of the iris. Arch. Ophthalmol. 1992;110:969–976.
Damato BE, Foulds WS. In: Schachat AP, Ryan SJ, eds. Retina. 4th ed. St Louis: Mosby, 2006:769–778.
Tiberti A, Damato B, Hiscott P, Vora J. Iris ectopic thyroid tissue. Report of a case. Arch. Ophthalmol. 2006 (in press).
Brannan SO, Lessan NG, Hiscott P, et al. A choroidal amyloid-rich neuroendocrine tumor: initial manifestation of Cushing syndrome. Arch. Ophthalmol. 1999;117:1081–1083.
Bechrakis NE, Foerster MH, Bornfeld N. Biopsy in indeterminate intraocular tumors. Ophthalmology 2002;109:235–242.
Kvanta A, Seregard S, Kopp ED, et al. Choroidal biopsies for intraocular tumors of indeterminate origin. Am. J. Ophthalmol. 2005;140:1002–1006.
Fujii GY, De Juan E Jr, Humayun MS, et al. A new 25-gauge instrument system for transconjunctival sutureless vitrectomy surgery. Ophthalmology 2002;109:1807–1812.
Finger PT, Latkany P, Kurli M et al. The Finger iridectomy technique: small incision biopsy of anterior segment tumours. Br. J. Ophthalmol. 2005;89:946–949.
Sen J, Groenewald C, Hiscott PS, Smith P, Damato BE. Trans-retinal choroidal tumor biopsy with a 25-gauge vitrector. Ophthalmology 2006;113:1028–1031.
Inoue M, Noda K, Ishida S, et al. Intraoperative breakage of a 25-gauge vitreous cutter. Am. J. Ophthalmol. 2004;138:867–869.
Collaborative Ocular Melanoma Study Group. Factors predictive of growth and treatment of small choroidal melanoma. COMS report no. 5. Arch. Ophthalmol. 1997;115:1537–1544.
Manschot WA, Lee WR, van Strik R. Uveal melanoma: updated considerations on current management modalities. Int. Ophthalmol. 1995;19:203–209.
Eskelin S, Pyrhonen S, Summanen P, et al. Tumor doubling times in metastatic malignant melanoma of the uvea: tumor progression before and after treatment. Ophthalmology 2000;107:1443–1449.
Horsman DE, Sroka H, Rootman J, et al. Monosomy 3 and isochromosome 8q in a uveal melanoma. Cancer Genet. Cytogenet. 1990;45:249–253.
Horsthemke B, Prescher G, Bornfeld N, et al. Loss of chromosome 3 alleles and multiplication of chromosome 8 alleles in uveal melanoma. Genes Chromosomes Cancer 1992;4:217–221.
Parrella P, Sidransky D, Merbs SL. Allelotype of posterior uveal melanoma: implications for a bifurcated tumor progression pathway. Cancer Res. 1999;59:3032–3037.
Prescher G, Bornfeld N, Hirche H, et al. Prognostic implications of monosomy 3 in uveal melanoma. Lancet 1996;347:1222–1225.
Scholes AG, Damato BE, Nunn J, et al. Monosomy 3 in uveal melanoma: correlation with clinical and histologic predictors of survival. Invest. Ophthalmol. Vis. Sci. 2003;44:1008–1011.
Tschentscher F, Husing J, Holter T, et al. Tumor classification based on gene expression profiling shows that uveal melanomas with and without monosomy 3 represent two distinct entities. Cancer Res. 2003;63:2578–2584.
Shields CL, Shields JA, Perez N, et al. Primary transpupillary thermotherapy for small choroidal melanoma in 256 consecutive cases: outcomes and limitations. Ophthalmology 2002;109:225–234.
Damato B, Coupland S, Hiscott PS. Classification of uveal tumors. In: Clinical ocular oncology, Eds. Singh AD, Damato BE, Pe-er J, Murphree AL, Perry JD. Elsevier, Amsterdam (in press).
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Damato, B., Groenewald, C. (2007). 25-Gauge Biopsy of Uveal Tumors. In: Kirchhof, B., Wong, D. (eds) Vitreo-retinal Surgery. Essentials in Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-33670-9_8
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