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Platelet-derived Growth Factor: Impact on Physiological and Tumor Angiogenesis

  • Chapter
Tumor Angiogenesis

Abstract

The PDGF growth factors make up a family of five dimeric growth factors acting through the two dimeric tyrosine kinase PDGF α-and ß-receptors. This chapter summarizes the findings, predominantly from analyses of genetically modified mice, which have established important functions for PDGF receptor signaling in the recruitment and growth of vascular mural cells. The text also reviews studies which have confirmed important roles of PDGF receptor signaling in tumor angiogenesis, predominantly involving effects on the mural cells. Thereafter, preclinical studies demonstrating anti-angiogenic and anti-tumoral effects of PDGF inhibitors are reviewed. Finally, results from clinical studies using drugs that block PDGF-receptors are discussed.

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Authors and Affiliations

  1. Cancer Center Karolinska, R8:03

    Arne Östman PhD (Professor of Molecular Oncology)

  2. Dept. of Oncology-Pathology, Karolinska Institutet, SE-171 76, Stockholm, Sweden

    Arne Östman PhD (Professor of Molecular Oncology) & Dr. Christer Betsholtz (Professor)

  3. Karolinska Institutet, Cancer Center Karolinska, R8:03, Sweden

    Dr. Christer Betsholtz (Professor)

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  1. Arne Östman PhD
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  2. Dr. Christer Betsholtz
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Editors and Affiliations

  1. Klinik für Tumorbiologie, Breisacher Str. 117, 79106, Freiburg i. Br., Germany

    Dieter Marmé PhD (Professor) (Professor)

  2. DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Norbert Fusenig MD (Professor, former Head of Division of Carcinogenesis and Differentiation) (Professor, former Head of Division of Carcinogenesis and Differentiation)

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Östman, A., Betsholtz, C. (2008). Platelet-derived Growth Factor: Impact on Physiological and Tumor Angiogenesis. In: Marmé, D., Fusenig, N. (eds) Tumor Angiogenesis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-33177-3_9

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  • DOI: https://doi.org/10.1007/978-3-540-33177-3_9

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  • Print ISBN: 978-3-540-33176-6

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