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Tumor Angiogenesis pp 545–555Cite as

Visualization of Microcirculation and Anti-Angiogenic Tumor Therapy

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Abstract

Mechanistic analysis of processes involved in tumor angiogenesis and vascularization requires sophisticated in vivo experimental models and techniques. Intravital microscopy allows for direct assessment of tumor angiogenesis, microcirculation and overall perfusion. Furthermore, recent advances in intravital microscopy now enable detailed anaysis of tumor blood vessel permeability, tumor oxygenation and imaging of blood vessel-specific epitopes at the molecular level, as well as intra- and extravascular cell-cell interactions. With the recent advances in the field of bioluminescence and fluorescent reporter genes, appropriate for in vivo imaging, the intravital fluorescent microscopic approach has to be considered a powerful tool to study microvascular, cellular and molecular mechanisms of tumor growth.

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Authors and Affiliations

  1. Department of Neurosurgery, Universitätsmedizin Charité Berlin Campus Virchow-Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany

    Dr. med. Marcus Czabanka & Professor Dr. med. Peter Vajkoczy

Authors
  1. Dr. med. Marcus Czabanka
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  2. Professor Dr. med. Peter Vajkoczy
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Editors and Affiliations

  1. Klinik für Tumorbiologie, Breisacher Str. 117, 79106, Freiburg i. Br., Germany

    Dieter Marmé PhD (Professor) (Professor)

  2. DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Norbert Fusenig MD (Professor, former Head of Division of Carcinogenesis and Differentiation) (Professor, former Head of Division of Carcinogenesis and Differentiation)

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© 2008 Springer-Verlag Berlin Heidelberg

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Czabanka, M., Vajkoczy, P. (2008). Visualization of Microcirculation and Anti-Angiogenic Tumor Therapy. In: Marmé, D., Fusenig, N. (eds) Tumor Angiogenesis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-33177-3_31

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  • DOI: https://doi.org/10.1007/978-3-540-33177-3_31

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-33176-6

  • Online ISBN: 978-3-540-33177-3

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