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Pharmakotherapie

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Book cover Pädiatrische Rheumatologie

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Nichtsteroidale Antirheumatika (NSAR) sind die am häufigsten eingesetzte Medikamentengruppe. Sie hemmen die Cyclooxygenase (COX-1 und COX-2) und greifen damit in die Prostaglandinsynthese ein. Vor allem die analgetischen und antiphlogistischen Eigenschaften begründen die häufige Verwendung. Neben den rheumatischen Erkrankungen, für die im Wesentlichen NSAR rezeptiert werden, zählen Schmerzzustände, insbesondere Spannungskopfschmerzen, Fieber, Dysmenorrhoe, Sportverletzungen, aber auch der prophylaktische Einsatz für thromboembolische Ereignisse und intestinale Polyposis gehört zu den Indikationsgebieten. In vielen Ländern, so auch in Deutschland, sind NSAR z. T. rezeptfrei erhältlich, so dass die Selbstmedikation ohne direkte ärztliche Supervision eine wesentliche Rolle bei der Vermarktung spielt. In den USA werden gezielt verbraucherbezogene Werbekampagnen für NSAR durchgeführt. Mehr als 20% der Menschen über 65 Jahren nehmen häufig NSAR ein.

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Literatur

  • Adachi Y, Inaba M, Amoh Y et al. (1995) Effect of bone marrow transplantation on antiphospholipid antibody syndrome in murine lupus mice. Immunobiology 192: 218–230

    PubMed  CAS  Google Scholar 

  • Ahern MJ, Harrison W, Hollingsworth P, Bradley J, Laing B, Bayliss C (1991) A randomised double-blind trial of cyclosporin and azathioprine in refractory rheumatoid arthritis. Aust N Z J Med 21(6): 844–849

    PubMed  CAS  Google Scholar 

  • Aries PM, Hellmich B, Gross WL (1986) Glucocorticoide: Stellenwert in der Therapie der Vaskulitis. Z Rheumatol 64: 155–161

    Google Scholar 

  • Anderson CC, Matzinger P (2001) Immunity or tolerance: Opposite outcomes of microchimerism from skin grafts. Nat Med 7: 80–87

    PubMed  CAS  Google Scholar 

  • Austin HA, Klippel JH, Balow JE et al. (1986) Therapy of lupus nephritis. Controlled trial of prednisone and cytotoxic drugs. N Engl J Med 314: 614–619

    PubMed  Google Scholar 

  • Barnett ML, Kremer JM, St Clair EW et al. (1998) Treatment of rheumatoid arthritis with oral type II collagen: Results of a multicenter, double blind, placebo-controlled trial. Arthritis Rheum 41: 290–297

    PubMed  CAS  Google Scholar 

  • Barron KS, Wallace C, Woolfrey CEA et al. (2001) Autologous stem cell transplantation for pediatric rheumatic diseases. J Rheumatol 28: 2337–2358

    PubMed  CAS  Google Scholar 

  • Benenson E, Fries JW, Heilig B, Pollok M, Rubbert A (2005) High-dose azathioprine pulse therapy as a new treatment option in patients with active Wegener’s granulomatosis and lupus nephritis refractory or intolerant to cyclophosphamide. Clin Rheumatol 24(3): 251–257

    PubMed  CAS  Google Scholar 

  • Berry H, Liyanage SP, Durance RA, Barnes CG, Berger LA, Evans S (1976) Azathioprine and penicillamine in treatment of rheumatoid arthritis: a controlled trial. Br Med J 1(6017): 1052–1054

    PubMed  CAS  Google Scholar 

  • Blumenauer B, Judd M, Cranney A et al. (2003) Etanercept for the treatment of rheumatoid arthritis. Cochrane Database Syst Rev (4): CD004525

    PubMed  Google Scholar 

  • Breit W, Frosch M, Meyer U, et al. (2000) A subgroup-specific evaluation of the efficacy of intraarticular triamcinolone hexacetonide in juvenile chronic arthritis. J Rheumatol 27: 2696–26702

    PubMed  CAS  Google Scholar 

  • Brewer EJ, Giannini EH, Kuzmina N, Alekseev L (1986) Penicillamine and hydroxychloroquine in the treatment of severe juvenile rheumatoid arthritis. Results of the U.S.A.-U.S.S.R. double-blind placebocontrolled trial. N Engl J Med 314: 1269–1276

    PubMed  CAS  Google Scholar 

  • Buttgereit F, da Silva JA, Boers M et al. (2002) Standardised nomenclature for glucocorticoid dosages and glucocorticoid treatment regimens: Current questions and tentative answers in rheumatology. Ann Rheum Dis 61: 718–722

    PubMed  CAS  Google Scholar 

  • Buttgereit F, Straub RH, Wehling M, Burmester G-R (2004) Glucocorticoids in the treatment of rheumatic diseases: An update on the mechanisms of action. Arthritis Rheum 50: 3408–3417

    PubMed  CAS  Google Scholar 

  • Calin A (1986) A placebo controlled, crossover study of azathioprine in Reiter’s syndrome. Ann Rheum Dis 45(8): 653–655

    PubMed  CAS  Google Scholar 

  • Candy S, Wright J, Gerber M, Adams G, Gerig M, Goodman R (1995) A controlled double blind study of azathioprine in the management of Crohn’s disease. Gut 37(5): 674–678

    PubMed  CAS  Google Scholar 

  • Cassidy JT, Petty RE (2002) Juvenile rheumatoid arthritis. In: Cassidy JT, Petty RE (eds) Textbook of pediatric rheumatology, 4th edn. Saunders, Philadelphia, pp 218–321

    Google Scholar 

  • Chen TC, Cobbold SP, Fairchild PJ, Waldmann H (2004) Generation of anergic and regulatory T cells following prolonged exposure to a harmless antig. J Immunol 172: 5900–5907

    PubMed  CAS  Google Scholar 

  • Clark P, Casas E, Tugwell P, Medina C, Gheno C, Tenorio G et al. (1993) Hydroxychloroquine compared with placebo in rheumatoid arthritis. A randomized controlled trial. Ann Intern Med 119(11): 1067–1071

    PubMed  CAS  Google Scholar 

  • Connell WR, Kamm MA, Dickson M et al. (1994) Long-term neoplasia risk after azathioprine treatment in inflammatory bowel disease. Lancet 343: 1249–1252

    PubMed  CAS  Google Scholar 

  • Contreras G, Pardo V, Leclercq et al. (2004) Sequential therapies for proliferative lupus nephritis. N Engl 350: 971–980

    CAS  Google Scholar 

  • Cutolo M, Sulli A, Pizzorni C, Seriolo B, Straub RH (2001) Anti-inflamatory mechanisms of methotrexate in rheumatoid arthritis. Ann Rheum Dis 60: 729–735

    PubMed  CAS  Google Scholar 

  • De Benedetti F, Massa M, Pignatti P, Albani S, Novick D, Martini A (1994) Serum soluble interleukin 6 (IL-6) receptor and IL-6/soluble IL-6 receptor complex in systemic juvenile rheumatoid arthritis. J Clin Invest 93: 2114–2119

    PubMed  Google Scholar 

  • De Silva M, Hazleman BL (1981) Long-term azathioprine in rheumatoid arthritis: a double-blind study. Ann Rheum Dis 40(6): 560–563

    PubMed  Google Scholar 

  • Elliott MJ, Maini RN, Feldmann M et al. (1994) Randomized double-blind comparison of chimeric monoclonal antibody to tumor necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis. Lancet 344(8930): 1105–1110

    PubMed  CAS  Google Scholar 

  • Flores M, Gudino PR, Rios PR, Almedia A, V, Castrejon Vazquez MI, Ocampo AA (2001) Comparative study of the treatment of autoimmune uveitis with prednisone and with cyclophosphamide and azathioprine. Rev Alerg Mex 48(3): 75–79

    PubMed  CAS  Google Scholar 

  • Fox RI, Dixon R, Guarrasi V, Krubel S (1996) Treatment of primary Sjogren’s syndrome with hydroxychloroquine: a retrospective, open-label study. Lupus 5(Suppl 1): S31–S36

    PubMed  Google Scholar 

  • Fraser AG, Orchard TR, Robinson EM, Jewell DP (2002) Long-term risk of malignancy after treatment of inflammatory bowel disease with azathioprine. Aliment Pharmacol Ther 16: 1225–1232

    PubMed  CAS  Google Scholar 

  • Fu LW, Yang LY, Chen WP, Lin CY (1998) Clinical efficacy of cyclosporin a neoral in the treatment of paediatric lupus nephritis with heavy proteinuria. Brit J Rheumatol 37: 217–221

    CAS  Google Scholar 

  • Gare BA, Fasth A (1995a) The natural history of juvenile chronic arthritis: A population based cohort study. I. Onset and disease process. J Rheumatol 22: 295–307

    PubMed  CAS  Google Scholar 

  • Gare BA, Fasth A (1995b) The natural history of juvenile chronic arthritis: A population based cohort study. II. Outcome. J Rheumatol 22: 308–319

    PubMed  CAS  Google Scholar 

  • Gelder M van, Bekkum DW van (1995) Treatment of relapsing experimental autoimmune encephalomyelitis in rats with allogeneic bone marrow transplantation from a resistant strain. Bone Marrow Transplant 16: 343–351

    PubMed  Google Scholar 

  • Gelder M van, Bekkum DW van (1996) Effective treatment of relapsing experimental autoimmune encephalomyelitis with pseudoautologous bone marrow transplantation. Bone Marrow Transplant 18: 1029–1034

    PubMed  Google Scholar 

  • Gelder M van, Kinwel-Bohre EP, Bekkum DW van (1993) Treatment of experimental allergic encephalomyelitis in rats with total body irradiation and syngeneic BMT. Bone Marrow Transplant 11: 233–241

    PubMed  Google Scholar 

  • Giannini EH, Brewer EJ Jr, Kuzmina N, Shaikov A, Wallin B (1990) Auranofin in the treatment of juvenile rheumatoid arthritis (1990) Results of the USA-USSR double-blind, placebo-controlled trial. The USA Pediatric Rheumatology Collaborative Study Group. The USSR Cooperative Children’s Study Group. Arthritis Rheum 33: 466–476

    PubMed  CAS  Google Scholar 

  • Giannini EH, Brewer EJ, Kuzmina N et al. (1992) Methotrexate in resistant juvenile rheumatoid arthritis. Results of the USA-USSR double-blind, placebo-controlled trial. The Pediatric Rheumatology Collaborative Study Group and The Cooperative Children’s Study Group. N Engl J Med 326: 1043–1049

    PubMed  CAS  Google Scholar 

  • Giannini EH, Cassidy JT, Brewer EJ, Shaikov A, Maximov A, Kuzima N (1993) Comparative efficacy and safety of advanced drug therapy in children with juvenile rheumatoid arthritis. Sem Arthritis Rheum 23(1): 34–46

    CAS  Google Scholar 

  • Giannini EH, Ruperto N, Ravelli A, Lovell DJ, Felson DT, Martini A (1997) Preliminary definition of improvement in juvenile arthritis. Arthritis Rheum 40: 1202–1209

    PubMed  CAS  Google Scholar 

  • Golding JR, Andrews FM, Camp V et al. (1995) A randomized trial of hydroxychloroquine in early rheumatoid arthritis: the HERA Study. Am J Med 98(2): 156–168

    Google Scholar 

  • Hagelberg S, Lee Y, Bargman J, Mah G, Schneider R, Laskin C et al. (2002) Longterm followup of childhood lupus nephritis. J Rheumatol 29(12): 2635–2642

    PubMed  Google Scholar 

  • Hamdy H, McKendry RJ, Mierins E, Liver JA (1987) Low-dose methotrexate compared with azathioprine in the treatment of rheumatoid arthritis. A twenty-four-week controlled clinical trial. Arthritis Rheum 30(4): 361–368

    PubMed  CAS  Google Scholar 

  • Hamuryudan V, Ozyazgan Y, Hizli N, Mat C, Yurdakul S, Tuzun Y et al. (1997) Azathioprine in Behcet’s syndrome: effects on long-term prognosis. Arthritis Rheum 40(4): 769–774

    PubMed  CAS  Google Scholar 

  • Hamuryudan V, Ozyazgan Y, Fresko Y, Mat C, Yurdakul S, Yazici H. (2002) Interferon alfa combined with azathioprine for the uveitis of Behcet’s disease: an open study. Isr Med Assoc J 4(Suppl 11): 928–930

    PubMed  CAS  Google Scholar 

  • Hawkins PN, Bybee A, Aganna E, McDermott MF (2004) Response to anankinra in a de novo case of neonatal-onset multisystem inflamatory disease. Arthritis Rheum 50: 2708–2709

    PubMed  Google Scholar 

  • Hodis HN, Quismorio FP Jr, Wickham E, Blankenhorn DH (1993) The lipid, lipoprotein, and apolipoprotein effects of hydroxychloroquine in patients with systemic lupus erythematosus. J Rheumatol 20(4): 661–665

    PubMed  CAS  Google Scholar 

  • Holmberg LA, Boeckh M, Hooper H et al. (1999) Increased incidence of cytomegalovirus disease after autologous CD34-selected peripheral blood stem cell transplantation. Blood 94: 4029–4035

    PubMed  CAS  Google Scholar 

  • Horneff G (2005) Importance of the new biologicals and cytokine antagonists in the treatment of juvenile idiopathic arthritis (JIA). Z Rheumatol 64: 317–326

    PubMed  CAS  Google Scholar 

  • Hough RE, Snowden JA, Wulffraat NM (2005) Haemopoietic stem cell transplantation in autoimmune diseases: A European perspective. Br J Haematol 128: 432–459

    PubMed  CAS  Google Scholar 

  • Huppertz HI, Tschammier A, Horwitz A, Schwab O (1995) Intraarticular corticosteroids for chronic arthritis in children: Efficacy and effects on cartilage and growth. J Pediatr 127: 317–321

    PubMed  CAS  Google Scholar 

  • Ikehara S, Yasumizu R, Inaba M et al. (1989) Long-term observations of autoimmune-prone mice treated for autoimmune disease by allogeneic bone marrow transplantation. Proc Natl Acad Sci U S A 86: 3306–3310

    PubMed  CAS  Google Scholar 

  • Imundo LF, Jacobs JC (1996) Sulfasalazine therapy for juvenile rheumatoid arthritis. J Rheumatol 23: 360–366

    PubMed  CAS  Google Scholar 

  • Ito H, Takazoe M, Fukuda Y et al. (2004) A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn’s disease. Gastroenterology 126: 989–996

    PubMed  CAS  Google Scholar 

  • Jacobs JC (1977) Methotrexate and azathioprine treatment of childhood dermatomyositis. Pediatrics 59(2): 212–218

    PubMed  CAS  Google Scholar 

  • Jayne D, Rasmussen N, Andrassy K, Bacon P, Tervaert JW, Dadoniene J et al. (2003) A randomized trial of maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies. N Engl J Med 349(1): 36–44

    PubMed  CAS  Google Scholar 

  • Jeurissen ME, Boerbooms AM, van de Putte LB, Doesburg WH, Mulder J, Rasker JJ et al. (1991) Methotrexate versus azathioprine in the treatment of rheumatoid arthritis. A forty-eight-week randomized, double-blind trial. Arthritis Rheum 34(8): 961–972

    PubMed  CAS  Google Scholar 

  • Kari JA, Shah V, Dhillon MJ (2001) Behçet’s disease in UK children: Clinical features and treatment including thalidomide. Rheumatology 40: 933–938

    PubMed  CAS  Google Scholar 

  • Karussis DM, Slavin S, Lehmann D, Mizrachi-Koll R, Abramsky O, Ben Nun A (1992) Prevention of experimental autoimmune encephalomyelitis and induction of tolerance with acute immunosuppression followed by syngeneic bone marrow transplantation. J Immunol 148: 1693–1698

    PubMed  CAS  Google Scholar 

  • Keysser M (1993) Therapie der Rheumatoid-Arthritis (RA) mit Azathioprin — Ergebnisse einer offenen Langzeitstudie über mindestens 4 Jahre bei 528 Patienten. Z Rheumatol 52(3): 133–137

    PubMed  CAS  Google Scholar 

  • Kirwan JR, the Arthritis and Rheumatism Council Low-Dose Glucocorticoid Study Group (1995) The effect of glucocorticoids on joint destruction in rheumatoid arthritis. N Engl J Med 333: 142–146

    PubMed  CAS  Google Scholar 

  • Kishimoto T, Hamazaki T, Yasui M et al. (2003) Autologous hematopoietic stem cell transplantation for 3 patients with severe juvenile rheumatoid arthritis. Int J Hematol 78: 453–456

    PubMed  Google Scholar 

  • Kleer IM de, Brinkman DM, Ferster A et al. (2004) Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: Analysis of clinical effects, mortality, and transplant related morbidity. Ann Rheum Dis 63: 1318–1326

    PubMed  Google Scholar 

  • Knaan-Shanzer S, Houben P, Kinwel-Bohre EP, Bekkum DW van (1991) Remission induction of adjuvant arthritis in rats by total body irradiation and autologous bone marrow transplantation. Bone Marrow Transplant 8: 333–338

    PubMed  CAS  Google Scholar 

  • Krüger K, Schattenkirchner M (1994) Comparison of cyclosporin A and azathioprine in the treatment of rheumatoid arthritis—results of a double-blind multicentre study. Clin Rheumatol 13(2): 248–255

    PubMed  Google Scholar 

  • Kruize AA, Hene RJ, Kallenberg CG et al. (1993) Hydroxychloroquine treatment for primary Sjogren’s syndrome: a two year double blind crossover trial. Ann Rheum Dis 52(5): 360–364

    PubMed  CAS  Google Scholar 

  • Kvien TK, Hoyeraal HM, Sandstad B (1985) Slow acting antirheumatic drugs in patients with juvenile rheumatoid arthritis — evaluated in a randomized, parallel 50-week clinical trial. J Rheumatol 12(3):533–539

    PubMed  CAS  Google Scholar 

  • Kvien TK, Hoyeraal HM, Sandstad B (1986) Azathioprine versus placebo in patients with juvenile rheumatoid arthritis: a single center double blind comparative study. J Rheumatol 13:118–123

    PubMed  CAS  Google Scholar 

  • Laar JM van, Tyndall A (2003) Intense immunosuppression and stemcell transplantation for patients with severe rheumatic autoimmune disease: A review. Cancer Control 10: 57–65

    PubMed  Google Scholar 

  • Lahdenne P, Vahasalo P, Honkanen V (2003) Infliximab or etanercept in the treatment of children with refractory juvenile idiopathic arthritis: An open label study. Ann Rheum Dis 62: 245–247

    PubMed  CAS  Google Scholar 

  • Laxer RM (2005) Pharmacology and drug therapy. In: Cassidy JT, Petty R E, Laxer R M, Lindsley C B (eds) Textbook of pediatric rheumatology. Elsevier Saunders, Philadelphia, pp 76–141

    Google Scholar 

  • Lehman TJA, Edelheit BS, Onel KB (2004) Combined intravenous methotrexate and cyclophosphamide for refractory childhood lupus nephritis. Ann Rheum Dis 63: 321–323

    PubMed  CAS  Google Scholar 

  • Leipold G, Schutz E, Haas JP, Oellerich M (1997) Azathioprine-induced severe pancytopenia due to a homozygous two-point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis. Arthritis Rheum 40: 1896–1898

    PubMed  CAS  Google Scholar 

  • Levite M, Zinger H, Zisman E, Reisner Y, Mozes E (1995) Beneficial effects of bone marrow transplantation on the serological manifestations and kidney pathology of experimental systemic lupus erythematosus. Cell Immunol 162: 138–145

    PubMed  CAS  Google Scholar 

  • Li EK, Tam LS, Tomlinson B (2004) Leflunomide in the treatment of rheumatoid arthritis. Clin Ther 26: 447–459

    PubMed  CAS  Google Scholar 

  • Lin YT, Yang YH, Tsai MJ, Chiang BL (2000) Long-term effects of azathioprine therapy for juvenile rheumatoid arthritis. J Formos Med Assoc 99(4): 330–335

    PubMed  CAS  Google Scholar 

  • Mantzaris GJ, Sfakianakis M, Archavlis E, Petraki K, Christidou A, Karagiannidis A et al. (2004) A prospective randomized observer-blind 2-year trial of azathioprine monotherapy versus azathioprine and olsalazine for the maintenance of remission of steroid-dependent ulcerative colitis. Am J Gastroenterol 99(6): 1122–1128

    PubMed  CAS  Google Scholar 

  • Marmont AM (2001) Immunoablation followed or not by hematopoietic stem cells as an intense therapy for severe autoimmune diseases. New perspectives, new problems. Haematologica 86: 337–345

    PubMed  CAS  Google Scholar 

  • McAllister LD, Beatty PG, Rose J (1997) Allogeneic bone marrow transplant for chronic myelogenous leukemia in a patient with multiple sclerosis. Bone Marrow Transplant 19: 395–397

    PubMed  CAS  Google Scholar 

  • Meinao IM, Sato EI, Andrade LE, Ferraz MB, Atra E (1996) Controlled trial with chloroquine diphosphate in systemic lupus erythematosus. Lupus 5(3): 237–241

    PubMed  CAS  Google Scholar 

  • Michels H (2000) What is low-dose corticosteroid therapy in juvenile idiopathic arthritis? Z Rheumatol 59(Suppl 2): II/127–II/130

    CAS  Google Scholar 

  • Michels H, Reinhold-Keller E (2005) Systemische Vaskulitiden. In: Wahn U, Seger R, Wahn V, Holländer GA (Hrsg) Pädiatrische Allergologie und Immunologie. Urban & Fischer, München, S 826–850

    Google Scholar 

  • Miller LC, Michael AF, Kim Y (1987) Childhood dermatomyositis. Clinical course and long-term follow-up. Clin Pediatr (Phila) 26(11): 561–566

    CAS  Google Scholar 

  • Molad Y, Gorshtein A, Wysenbeek AJ, Guedj D, Majadla R, Weinberger A et al. (2002) Protective effect of hydroxychloroquine in systemic lupus erythematosus. Prospective long-term study of an Israeli cohort. Lupus 11(6): 356–361

    PubMed  CAS  Google Scholar 

  • Muijsers AO, Stadt RJ van de, Henrichs AM, Ament HJ, Korst JK van der (1984) D-penicillamine in patients with rheumatoid arthritis. Serum levels, pharmacokinetic aspects, and correlation with clinical course and side effects. Arthritis Rheum 27: 1362–1369

    PubMed  CAS  Google Scholar 

  • Muraro PA, Douek DC, Packer A et al. (2005) Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients. J Exp Med 201: 805–816

    PubMed  CAS  Google Scholar 

  • Nakagawa R, Kawano Y, Yoshimura E et al. (2001) Intense immunosuppression followed by purified blood CD34+ cell autografting in a patient with refractory juvenile rheumatoid arthritis. Bone Marrow Transplant 27: 333–336

    PubMed  CAS  Google Scholar 

  • Nayak V, Esdaile JM (1996) The efficacy of antimalarials in systemic lupus erythematosus. Lupus 5(Suppl 1): S23–S27

    PubMed  CAS  Google Scholar 

  • Neidel J, Boehnke M, Küster R-M (2002) The efficacy and safety of intraarticular corticosteroid therapy for coxitis in juvenile rheumatoid arthritis. Arthritis Rheum 46: 1620–1628

    PubMed  CAS  Google Scholar 

  • Nelson JL, Torrez R, Louie FM, Choe OS, Storb R, Sullivan KM (1997) Preexisting autoimmune disease in patients with long-term survival after allogeneic bone marrow transplantation. J Rheumatol Suppl 48: 23–29

    PubMed  CAS  Google Scholar 

  • Newburger JW, Takahashi M, Beiser AS et al. (1991) A single intravenous infusion of gamma globulin as compared with four infusions in the treatment of acute Kawasaki syndrome. N Engl J Med 324: 1633–1639

    PubMed  CAS  Google Scholar 

  • Ng YT, Ouvrier RA, Wu T (1998) Drug therapy in juvenile dermatomyositis: follow-up study. J Child Neurol 13(3): 109–112

    PubMed  CAS  Google Scholar 

  • O’Dell JR, Haire CE, Erikson N et al. (1996) Treatment of rheumatoid arthritis with methotrexate alone, sulfasalazine and hydroxychloroquine, or a combination of all three medications. N Engl J Med 334: 1287–1291

    PubMed  CAS  Google Scholar 

  • Olson NY, Lindsley CB (1989) Adjunctive use of hydroxychloroquine in childhood dermatomyositis. J Rheumatol 16(12): 1545–1547

    PubMed  CAS  Google Scholar 

  • Osiri M, Shea B, Robinson V et al. (2003) Leflunomide for the treatment of rheumatoid arthritis: A systematic review and metaanalysis. J Rheumatol 30: 1182–1190

    PubMed  CAS  Google Scholar 

  • Paulus HE, Williams HJ, Ward JR, Reading JC, Egger MJ, Coleman ML et al. (1984) Azathioprine versus D-penicillamine in rheumatoid arthritis patients who have been treated unsuccessfully with gold. Arthritis Rheum 27(7): 721–727

    PubMed  CAS  Google Scholar 

  • Peterson LS, Nelson AM, Su WP (1995) Classification of morphea (localized scleroderma). Mayo Clin Proc 70(11): 1068–1076

    PubMed  CAS  Google Scholar 

  • Prakash A, Jarvis B (1999) Leflunomide: A review of its use in active rheumatoid arthritis. Drugs 58: 1137–1164

    PubMed  CAS  Google Scholar 

  • Quartier P, Taupin P, Bourdeaut F et al. (2003) Efficacy of etanercept for the treatment of juvenile idiopathic arthritis according to the onset type. Arthritis Rheum 48(4): 1093–1101

    PubMed  CAS  Google Scholar 

  • Rahman P, Gladman DD, Urowitz MB, Yuen K, Hallett D, Bruce IN (1999) The cholesterol lowering effect of antimalarial drugs is enhanced in patients with lupus taking corticosteroid drugs. J Rheumatol 26(2): 325–330

    PubMed  CAS  Google Scholar 

  • Ramakrishna J, Langhans N, Calenda K, Grand RJ, Verhave M (1996) Combined use of cyclosporine and azathioprine or 6-mercaptopurine in pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr 22(3): 296–302

    PubMed  CAS  Google Scholar 

  • Ravelli A, De Benedetti F, Viola S, Martini A (1996) Macrophage activation syndrome in systemic juvenile rheumatoid arthritis successfully treated with cyclosporine. J Pediatr 128: 275–278

    PubMed  CAS  Google Scholar 

  • Rhen T, Cidlowski JA (2005) Antiinflammatory action of glucocorticoids — new mechanisms for old drugs. N Engl J Med 353: 1711–1723

    PubMed  CAS  Google Scholar 

  • Roberts MM, To LB, Gillis D, Mundy J, Rawling C, Ng K, Juttner CA (1993) Immune reconstitution following peripheral blood stem cell transplantation, autologous bone marrow transplantation and allogeneic bone marrow transplantation. Bone Marrow Transplant 12:469–475

    PubMed  CAS  Google Scholar 

  • Ruperto N, Murray KJ, Gerloni V et al. (2004) A randomized trial of parenteral methotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexate. Arthritis Rheum 50:2191–2201

    PubMed  CAS  Google Scholar 

  • Rynes RI (2001) Antimalarial drugs. In: Ruddy S, Harris E D, Sledge C B (eds) Kelley’s textbook of rheumatology. Saunders, Philadelphia, pp 859–867

    Google Scholar 

  • Saenz A, Ausejo M, Shea B, Wells G, Welch V, Tugwell P (2000) Pharmacotherapy for Behcet’s syndrome. Cochrane Database Syst Rev 2:CD001084

    Google Scholar 

  • Savolainen HA, Kautiainen H, Isomaki H, Aho K, Verronen P (1997) Azathioprine in patients with juvenile chronic arthritis: a longterm followup study. J Rheumatol 24(12): 2444–2450

    PubMed  CAS  Google Scholar 

  • Sawhney S, Woo P, Murray KJ (2001) Macrophage activation syndrome: A potentially fatal complication of rheumatic disorders. Arch Dis Child 85: 421–426

    PubMed  CAS  Google Scholar 

  • Schimmer BP, Parker KL (2001) Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogs; inhibitors of the synthesis and actions of adrenocortical hormones. In: Hardman JG, Limbird LE (eds) Goodman & Gilman’s The pharmacological basis of therapeutics, 10th edn. McGraw-Hill, New York, pp 1663–1666

    Google Scholar 

  • Silman AJ, Petrie J, Hazleman B, Evans SJ (1988) Lymphoproliferative cancer and other malignancy in patients with rheumatoid arthritis treated with azathioprine: A 20 year follow up study. Ann Rheum Dis 47: 988–992

    PubMed  CAS  Google Scholar 

  • Silverman E, Mouy R, Spiegel L et al (2005a) Leflunomide or methotrexate for juvenile rheumatoid arthritis. N Engl J Med 352: 1655–1666

    PubMed  CAS  Google Scholar 

  • Silverman E, Spiegel L, Hawkins D et al. (2005b) Long-term open-label preliminary study of the safety and efficacy of leflunomide in patients with polyarticular-course juvenile rheumatoid arthritis. Arthritis Rheum 52: 554–562.

    PubMed  CAS  Google Scholar 

  • Singh G, Fries JF, Spitz P, Williams CA (1989) Toxic effects of azathioprine in rheumatoid arthritis. A national post-marketing perspective. Arthritis Rheum 32: 837–843

    PubMed  CAS  Google Scholar 

  • Smith JA, Thompson DJ, Whitcup SM et al. (2005) A randomized, placebo-controlled, double-masked clinical trial of etanercept for the treatment of uveitis associated with juvenile idiopathic arthritis. Arthritis Rheum 53: 18–23

    PubMed  CAS  Google Scholar 

  • Snowden JA, Kearney P, Kearney A et al. (1998) Long-term outcome of autoimmune disease following allogeneic bone marrow transplantation. Arthritis Rheum 41: 453–459

    PubMed  CAS  Google Scholar 

  • Stephan JL, Zeller J, Hubert P, Herbelin C, Dayer JM, Prieur AM (1993) Macrophage activation syndrome and rheumatic disease in childhood: A report of four new cases. Clin Exp Rheumatol 11: 451–456

    PubMed  CAS  Google Scholar 

  • Stoeber E (1976) Corticosteroid treatment of juvenile chronic polyarthritis over 22 years. Eur J Pediatr 121: 141–147

    PubMed  CAS  Google Scholar 

  • Stoeber E, Kolle G, Graner HP (1967) Immunosuppressive Therapie bei Kindern. Erste Erfahrungen mit Azthioprin (Imuran) bei Still-Syndrom und rheumatoider Arthritis. Munch Med Wochenschr 109(37):1892–1899

    PubMed  CAS  Google Scholar 

  • Suarez-Almazor ME, Spooner C, Belseck E (2000) Penicillamine for treating rheumatoid arthritis. Cochrane Database Syst Rev (4): CD001460

    PubMed  Google Scholar 

  • Suarez-Almazor ME, Spooner CH, Belseck E, Shea B (2000) Auranofin versus placebo in rheumatoid arthritis. Cochrane Database Syst Rev (2):CD002048

    PubMed  Google Scholar 

  • Sykes M, Nikolic B (2005) Treatment of severe autoimmune disease by stem-cell transplantation. Nature 435: 620–627

    PubMed  CAS  Google Scholar 

  • Talmadge JE, Reed E, Ino K et al. (1997) Rapid immunologic reconstitution following transplantation with mobilized peripheral blood stem cells as compared to bone marrow. Bone Marrow Transplant 19: 161–172

    PubMed  CAS  Google Scholar 

  • Tishler M, Yaron I, Shirazi I, Yaron M (1999) Hydroxychloroquine treatment for primary Sjogren’s syndrome: its effect on salivary and serum inflammatory markers. Ann Rheum Dis 58(4): 253–256

    PubMed  CAS  Google Scholar 

  • Touraine JL, Roncarolo MG, Raudrant D, Bacchetta R, Golfier F, Sembeil R, Gebuhrer L (2005) Induction of transplantation tolerance in humans using fetal cell transplants. Transplant Proc 37: 65–66

    PubMed  Google Scholar 

  • Tsakonas E, Joseph L, Esdaile JM, Choquette D, Senecal JL, Cividino A et al. (1998) A long-term study of hydroxychloroquine withdrawal on exacerbations in systemic lupus erythematosus. The Canadian Hydroxychloroquine Study Group. Lupus 7(2): 80–85

    PubMed  CAS  Google Scholar 

  • Tsakonas E, Fitzgerald AA, Fitzcharles MA, Cividino A, Thorne JC, M’Seffar A et al. (2000) Consequences of delayed therapy with second-line agents in rheumatoid arthritis: a 3 year followup on the hydroxychloroquine in early rheumatoid arthritis (HERA) study. J Rheumatol 27(3): 623–629

    PubMed  CAS  Google Scholar 

  • Tyndall A, Gratwohl A (1997) Blood and marrow stem cell transplants in auto-immune disease: A consensus report written on behalf of the European League against Rheumatism (EULAR) and the European Group for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplant 19: 643–645

    PubMed  CAS  Google Scholar 

  • Unger L, Kayser M, Enderlein M et al. (2005) Glucocorticoidtherapie bei Kollagenosen. Z Rheumatol 64: 162–169

    PubMed  CAS  Google Scholar 

  • Urowitz MB, Smythe HA, Able T et al. (1982) Long-term effects of azathioprine in rheumatoid arthritis. Ann Rheum Dis 41: 18–22

    PubMed  Google Scholar 

  • Van Rossum MA, Fiselier TJ, Franssen MJ et al. (1998) Sulfasalazine in the treatment of juvenile chronic arthritis: A randomized, double-blind, placebo-controlled, multicenter study. Dutch Juvenile Chronic Arthritis Study Group. Arthritis Rheum 41: 808–816

    PubMed  Google Scholar 

  • Verbsky JW, White AJ (2004) Effective use of the recombinant interleukin 1 receptor antagonist anakinra in therapy of resistant systemic onset juvenile rheumatoid arthritis. J Rheumatol 31: 2071–2075

    PubMed  Google Scholar 

  • Wallace CA, Levinson JE (1991) Juvenile rheumatoid arthritis: Outcome and treatment for the 1990s. Rheum Dis Clin North Am 17: 891–905

    PubMed  CAS  Google Scholar 

  • Weinblatt ME, Keystone EC, Furst DE, Kavanaugh AF, Chartash EK, Segurado OG (2006) Long-term efficacy and safety of adalimumab plus methotrexate in patients with rheumatoid arthritis: ARMADA 4-year extended study. Ann Rheum Dis 65: 753–759

    PubMed  CAS  Google Scholar 

  • Williams HJ, Egger MJ, Singer JZ, Willkens RF, Kalunian KC, Clegg DO et al. (1994) Comparison of hydroxychloroquine and placebo in the treatment of the arthropathy of mild systemic lupus erythematosus. J Rheumatol 21(8): 1457–1462

    PubMed  CAS  Google Scholar 

  • Wolfe F, Michaud K (2004) Lymphoma in rheumatoid arthritis: the effect of methotrexate and anti-tumor necrosis factor therapy in 18,572 patients. Arthritis Rheum 50: 1740–1751

    PubMed  CAS  Google Scholar 

  • Woo P, Southwood TR, Prieur AM et al. (2000) Randomized, placebo-controlled, crossover trial of low-dose oral methotrexate in children with extended oligoarticular or systemic arthritis. Arthritis Rheum 43: 1849–1857

    PubMed  CAS  Google Scholar 

  • Woo P, Wedderburn LR (1998) Juvenile chronic arthritis. Lancet 351: 969–973

    PubMed  CAS  Google Scholar 

  • Wulffraat NM, Kuis W, Petty R (1999a) Addendum: Proposed guidelines for autologous stem cell transplantation in juvenile chronic arthritis. Paediatric Rheumatology Workshop. Rheumatology (Oxford) 38:777–778

    CAS  Google Scholar 

  • Wulffraat NM, Royen A van, Bierings M, Vossen J, Kuis W (1999b) Autologous haemopoietic stem-cell transplantation in four patients with refractory juvenile chronic arthritis. Lancet 353: 550–553

    PubMed  CAS  Google Scholar 

  • Wulffraat NM, Rijkers GT, Elst E, Brooimans R, Kuis W (2003) Reduced perforin expression in systemic juvenile idiopathic arthritis is restored by autologous stem-cell transplantation. Rheumatology (Oxford) 42: 375–379

    CAS  Google Scholar 

  • Yazici H, Pazarli H, Barnes CG, Tuzun Y, Ozyazgan Y, Silman A et al. (1990) A controlled trial of azathioprine in Behcet’s syndrome. N Engl J Med 322(5): 281–285

    PubMed  CAS  Google Scholar 

  • Yokota S, Miyamae T, Imagawa T et al. (2005) Therapeutic efficacy of humanized recombinant anti-interleukin-6 receptor antibody in children with systemic-onset juvenile idiopathic arthritis. Arthritis Rheum 52: 818–825

    PubMed  CAS  Google Scholar 

  • Zierhut M, Michels H, Stübiger N et al. (2005) Uveitis in children. International Ophthalmology Clinics 5: 135–156

    Google Scholar 

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Authors and Affiliations

  1. Kinderklinik, Gehfeldstr. 24, 82467, Garmisch-Partenkirchen

    H. Michels (Dr. med.)

  2. Universitäts-Kinderklinik, Moorenstr. 5, 40225, Düsseldorf

    T. Niehues (Priv.-Doz. Dr. med.)

  3. Klinik für Kinder- und Jugendmedizin, RWTH Aachen, Pauwelsstr. 30, 52074, Aachen

    N. Wagner (Prof. Dr. med.)

  4. Wilhelmina Children’s Hospital, University Medical Center Utrecht, P.O. Box 85090, NL-3508, Utrecht, Niederlande

    J. M. de Kleer & N. M. Wulffraat (Prof. Dr.)

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  1. H. Michels
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  2. T. Niehues
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  3. N. Wagner
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  4. J. M. de Kleer
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  5. N. M. Wulffraat
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Editors and Affiliations

  1. Klinik für Kinder- und Jugendmedizin, RWTH Aachen, Pauwelsstr. 30, 52074, Aachen

    Norbert Wagner

  2. Olgahospital, Klinikum Stuttgart, Pädiatrisches Zentrum der Landeshauptstadt Stuttgart, Bismarckstr. 8, 70176, Stuttgart

    Günther Dannecker

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Michels, H., Niehues, T., Wagner, N., de Kleer, J.M., Wulffraat, N.M. (2007). Pharmakotherapie. In: Wagner, N., Dannecker, G. (eds) Pädiatrische Rheumatologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-32815-5_4

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