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Mechanisms of Spinal Cord Stimulation in Neuropathic and Vasculopathic Pain: Present Status of Knowledge — and Views for the Future

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Proceedings of the Medtronic Forum for Neuroscience and Neuro-Technology 2005

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References

  1. Ardell JL, Southerland EM, Milhorn D, Foreman RD, Linderoth B, DeJongste MJL, Armour JA. Pre-emptive spinal cord stimulation mitigates myocardial ischemia-induced infarction via alpha adrenergic receptors. Exp Biol 2005; 2–6, Abstract 356.10

    Google Scholar 

  2. Armour JA, Linderoth B, Arora RC, DeJongste MJ, Ardell JL, Kingma JG Jr, Hill M, Foreman RD. Long-.term modulation of the intrinsic cardiac nervous system by spinal cord neurons in normal and ischaemic hearts. Auton Neurosci 2002; 95: 71–79

    Article  PubMed  CAS  Google Scholar 

  3. Baron R, Levine JD, Fields HL. Causalgia and reflex sympathetic dystrophy: does the sympathetic nervous system contribute to the generation of pain? Muscle Nerve 1999; 22: 678–695

    Article  PubMed  CAS  Google Scholar 

  4. Cardinal R, Ardell JL, Linderoth B, Vermeulen M, Foreman RD, Armour JA. Spinal cord activation differentially modulates ischaemic electrical responses to different stressors in canine ventricles. Auton Neurosci 2004; 111: 37–47

    Article  PubMed  Google Scholar 

  5. Chandler MJ, Brennan TJ, Garrison DW, Kim KS, Schwartz PJ, Foreman RD. A mechanism of cardiac pain suppression by spinal cord stimulation: implications for patients with angina pectoris. Eur Heart J 1993; 14: 96–105

    PubMed  CAS  Google Scholar 

  6. Croom JE, Foreman RD, Chandler MJ, Barron KW. Re-evaluation of the role of the sympathetic nervous system in cutaneous vasodilation during dorsal spinal cord stimulation: are multiple mechanisms active? Neuromodulation 1998; 1: 91–101

    Google Scholar 

  7. Cui J-G, Linderoth B, Meyerson BA: Effects of spinal cord stimulation on touch-evoked allodynia involve GABAergic mechanisms. An experimental study in the mononeuropathic rat. Pain 1996; 66: 287–295

    Article  PubMed  CAS  Google Scholar 

  8. Cui JG, O’Connor WT, Ungerstedt U, Meyerson BA, Linderoth B. Spinal cord stimulation attenuates augmented dorsal horn release of excitatory amino acids in mononeuropathy via a GABAergic mechanism. Pain 1997b; 73: 87–95

    Article  PubMed  CAS  Google Scholar 

  9. Cui JG, Sollevi A, Linderoth B, Meyerson BA. Adenosine receptor activation suppresses tactile hypersensitivity and potentiates effect of spinal cord in mononeuropathic rats. Neurosci Lett 1997c; 223: 173–176

    Article  PubMed  CAS  Google Scholar 

  10. Cui JG, Meyerson BA, Sollevi A, Linderoth B. Effects of spinal cord stimulation on tactile hypersensitivity in mononeuropathic rats is potentiated by GABAB and adenosine receptor activation. Neurosci Lett 1998; 247: 183–186

    Article  PubMed  CAS  Google Scholar 

  11. Eliasson T, Augustinsson LE, Mannheimer C. Spinal cord stimulation in severe angina pectoris-presentation of current studies, indications and clinical experience. Pain 1995; 65: 169–179

    Article  Google Scholar 

  12. El-Khoury C, Hawwa N, Baliki M, Atweh SF, Jabbur SJ, Saade NE. Attenuation of neuropathic pain by segmental and supraspinal activation of the dorsal column system in awake rats. Neuroscience 2002; 112: 541–553

    Article  PubMed  CAS  Google Scholar 

  13. Foreman RD, DeJongste MJL, Linderoth B. Integrative control of cardiac function by cervical and thoracic spinal neurons. In: Armour JA, Ardell JL (eds) Basic and clinical neurocardiology. Oxford University Press, London, 2004;153–186

    Google Scholar 

  14. Foreman RD, Linderoth B, Ardell JL, Barron KW, Chandler MJ, Hull Jr. SS, TerHorst GJ, DeJongste MJL, Armour JA. Modulation of intrinsic cardiac neurons by spinal cord stimulation: implications for therapeutic use in angina pectoris. Cardiovasc Res 2000; 47: 367–375

    Article  PubMed  CAS  Google Scholar 

  15. Harke H, Gretenkort P, Ladleif HU, Rahman S. Spinal cord stimulation in sympathetically maintained complex regional pain syndrome type I with severe disability. A prospective clinical study. Eur J Pain 2005; 9: 363–373

    Article  PubMed  Google Scholar 

  16. Hautvast RW, Blanksma PK, DeJongste MJ, Pruim J, van der Wall EE, Vaalburg W, Lie KI. Effect of spinal cord stimulation on myocardial blood flow assessed by positron emission tomography in patients with refractory angina pectoris. Am J Cardiol 1996; 77: 462–467

    Article  PubMed  CAS  Google Scholar 

  17. Kemler MA, Barendse GA, van Kleef M, Egbrink MG. Pain relief in complex regional pain syndrome due to spinal cord stimulation does not depend on vasodilation. Anesthesiology 2000a; 92: 1653–1660

    Article  PubMed  CAS  Google Scholar 

  18. Kemler MA, Barendse GA, van Kleef M, de Vet HC, Rijks CP, Furnee CA, van den Wildenberg FA. Spinal cord stimulation in patients with chronic reflex sympathetic dystrophy. N Engl J Med 2000b; 343: 618–624

    Article  PubMed  CAS  Google Scholar 

  19. Kingma JG, Linderoth B, Ardell JL, Armour JA, DeJongste MJL, Foreman RD. Neuromodulation therapy does not influence blood flow distribution or left ventricular dynamics during acute myocardial ischaemia. Auton Neurosci Basic Clin 2001; 91: 47–54

    Article  Google Scholar 

  20. Kumar K, Nath RK, Tooth C. Spinal cord stimulation is effective in the management of reflex sympathetic dystrophy. Neurosurgery 1997; 40: 736–747

    Article  PubMed  CAS  Google Scholar 

  21. Lind G, Meyerson BA, Winter J, Linderoth B. Intrathecal baclofen as adjuvant therapy to enhance the effect of spinal cord stimulation in neuropathic pain: a pilot study. Eur J Pain 2004; 8: 877–883

    Article  CAS  Google Scholar 

  22. Lindblom U, Meyerson BA. Influence of touch, vibration and cutaneous pain of dorsal column stimulation in man. Pain 1975; 1: 257–270

    Article  PubMed  CAS  Google Scholar 

  23. Linderoth B, Foreman RD. Physiology of spinal cord stimulation. Review and Update. Neuromodulation 1999; 2: 150–164

    Article  Google Scholar 

  24. Linderoth B, Fedorcsak I, Meyerson BA. Peripheral vasodilatation after spinal cord stimulation: animal studies of putative effector mechanisms. Neurosurgery 1991; 2: 187–195

    Article  Google Scholar 

  25. Linderoth B, Gazelius B, Franck J, Brodin E. Dorsal column stimulation induces release of serotonin and substance P in the cat dorsal horn. Neurosurgery 1992; 31: 289–297

    PubMed  CAS  Google Scholar 

  26. Linderoth B, Gunasekera L, Meyerson BA. Effects of sympathectomy on skin and muscle microcirculation during dorsal column stimulation: animal studies. Neurosurgery 1991; 29: 874–879

    Article  PubMed  CAS  Google Scholar 

  27. Linderoth B, Herregodts P, Meyerson BA. Sympathetic mediation of peripheral vasodilation induced by spinal cord stimulation: animal studies of the role of cholinergic and adrenergic receptor subtypes. Neurosurgery 1994; 35: 711–719

    PubMed  CAS  Google Scholar 

  28. Linderoth B. Spinal cord stimulation in ischemia and ischemic pain. In: Horsch S, Claeys L (eds) Spinal cord stimulation: an innovative method in the treatment of PVD and angina. Steinkopff Verlag, Darmstadt, 1995, pp 19–35

    Google Scholar 

  29. Linderoth B, Meyerson BA. Dorsal column stimulation: modulation of somatosensory and autonomic function. In: McMahon SB, Wall PD (eds) The neurobiology of pain. Seminars in the Neurosciences, vol 7. Academic Press, London, 1995, pp 263–277

    Google Scholar 

  30. Linderoth B, Foreman RD. Physiology of spinal cord stimulation. Review and Update. Neuromodulation 1999; 2: 150–164

    Article  Google Scholar 

  31. Linderoth B, Meyerson BA. Spinal cord stimulation: I: Mechanisms of action. In: Burchiel KJ (ed) Surgical management of pain. Thieme, Stuttgart New York; 2002, pp 505–526

    Google Scholar 

  32. Linderoth B, Simpson B, Meyerson BA. Spinal cord and brain stimulation. In: McMahon S, Kolzenburg M (eds) Wall and Melzack’s textbook of pain, 5th edn. Elsevier, Amsterdam; 2005

    Google Scholar 

  33. Mannheimer C, Eliasson T, Andersson B, Bergh CH, Augustinsson LE, Emanuelsson H, Waagstein F. Effects of spinal cord stimulation in angina pectoris induced by pacing and possible mechanism of action. Br Med J 1993; 307: 477–480

    Article  CAS  Google Scholar 

  34. Melzack R, Wall PD. Pain mechanisms: a new theory. Science 1965; 150: 971–979

    Article  PubMed  CAS  Google Scholar 

  35. Meyerson BA, Linderoth B. Therapeutic electrical neurostimulation from a historical perspective. In: Merskey H, Loeser JD, Dubner R (eds) The paths of pain 1975–2005. IASP Press, Seattle; 2005, pp 313–327

    Google Scholar 

  36. Meyerson BA, Linderoth B. Mechanisms of spinal cord stimulation in neuropathic pain. Invited review. Neurol Res 2000; 22: 285–292

    PubMed  CAS  Google Scholar 

  37. Meyerson BA, Linderoth B. Spinal cord stimulation. In: Loeser JD (ed) Bonica’s management of pain, 3rd edn. Lippincott Williams and Wilkins, Philadelphia; 2000, pp 1857–1876

    Google Scholar 

  38. Meyerson BA, Linderoth B. Spinal cord Stimulation: mechanisms of action in neuropathic and ischemic pain. In: Simpson BA (ed) Electrical stimulation and the relief of pain, vol 15. Elsevier, New York; 2003, pp 161–182

    Google Scholar 

  39. Michaelis M. Coupling of sympathetic and somatosensory neurons following nerve injury: Mechanisms and potential significance for the generation of pain. In: Devor M, Rowbotham MC, Wiesenfeld Z (eds) Progress in pain research and management, vol 16. IASP Press, Seattle; 2000;645–656

    Google Scholar 

  40. Schechtmann G, Wallin J, Meyerson BA, Linderoth B. Intrathecal clonidine potentiates suppression of tactile hypersensitivity by spinal cord stimulation in a model of neuropathy. Anesth Analg 2004; 99: 135–139

    Article  PubMed  CAS  Google Scholar 

  41. Stanton-Hicks M. Spinal cord stimulation in the management of complex regional pain syndromes. Neuromodulation 1999; 2: 193–201

    Article  Google Scholar 

  42. Stiller CO, Cui J-G, O’Connor WT, Brodin E, Meyerson BA, Linderoth B. Release of GABA in the dorsal horn and suppression of tactile allodynia by spinal cord stimulation in mononeuropathic rats. Neurosurgery 1996; 39: 367–375

    Article  PubMed  CAS  Google Scholar 

  43. Tanaka S, Barron KW, Chandler MJ, Linderoth B, Foreman RD. Low intensity spinal cord stimulation may induce cutaneous vasodilation via CGRP release. Brain Res 2001; 896: 183–187

    Article  PubMed  CAS  Google Scholar 

  44. Tanaka S, Barron KW, Chandler MJ, Linderoth B, Foreman RD. Local cooling alters neural mechanisms producing changes in peripheral blood flow by spinal cord stimulation. Autonomic Neuroscience: Basic and Clinical 2003; 104: 117–127

    Article  Google Scholar 

  45. Tanaka S, Komori N, Barron KW, Chandler MJ, Linderoth B, Foreman RD. Mechanisms of sustained cutaneous vasodilation induced by spinal cord stimulation. Auton Neurosci 2004; 114: 55–60

    Article  PubMed  Google Scholar 

  46. Wallin J, Cui J-G, Yakhnitsa V, Meyerson BA, Linderoth B. Gabapentin and Pregabalin suppress tactile allodynia and potentiate spinal cord stimulation in a model of neuropathy. Europ J Pain 2002; 6: 261–272

    Article  CAS  Google Scholar 

  47. Wasner G, Schattschneider J, Heckmann K, Maier C, Baron R. Vascular abnormalities in reflex sympathetic dystrophy (CRPS I): Mechanisms and diagnostic value. Brain 2001; 124: 587–599

    Article  PubMed  CAS  Google Scholar 

  48. Yakhnitsa V, Linderoth B, Meyerson BA. Modulation of dorsal horn neuronal activity by spinal cord stimulation in a rat model of neuropathy: the role of the dorsal funicles. Neurophysiology 1998; 30: 424–427

    Article  Google Scholar 

  49. Yakhnitsa V, Linderoth B, Meyerson BA. Spinal cord stimulation attenuates dorsal horn neuronal hyperexcitability in a rat model of mononeuropathy. Pain 1999; 79: 223–233

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Dept. of Neurosurgery, Karolinska Institutet and Karolinska University Hospital, Nobels väg 5, Solna, Stockholm, 171 77, Sweden

    B. Linderoth

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  1. B. Linderoth
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Editors and Affiliations

  1. Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands

    Bob van Hilten

  2. Department of Neurology, Universitaire Ziekenhuizen Leuven, Herestraat 49, 3000, Leuven, Belgium

    Bart Nuttin

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Linderoth, B. (2007). Mechanisms of Spinal Cord Stimulation in Neuropathic and Vasculopathic Pain: Present Status of Knowledge — and Views for the Future. In: van Hilten, B., Nuttin, B. (eds) Proceedings of the Medtronic Forum for Neuroscience and Neuro-Technology 2005. Springer, Berlin, Heidelberg . https://doi.org/10.1007/978-3-540-32746-2_5

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  • DOI: https://doi.org/10.1007/978-3-540-32746-2_5

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