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Experimental and Pharmacokinetic Studies in Intraperitoneal Chemotherapy: From Laboratory Bench to Bedside

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Book cover Advances in Peritoneal Surface Oncology

Part of the book series: Resent Results in Cancer Research ((RECENTCANCER,volume 169))

Abstract

Extrapolation of experimental results to clinical practice should be done very carefully, because of the differences between the conditions on the laboratory bench and those in the human body. In the clinical setting, circumstances are much more complicated and drug activity is moderated by many physiological factors. On the other hand, the possibility of creating standardized conditions may be of great help for interpretation of treatment efficacy since great inter-individual differences may encumber this process. Furthermore, experimental studies provide indicative information that may be very valuable since it is practically impossible to study each treatment parameter in comparative clinical studies. The relatively small number of patients available for intraperitoneal chemotherapy trials complicates clinical evaluation of optimal treatment.

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  1. Department of Surgical Oncology, Medical School of Crete University Hospital, Herakleion, Greece

    Eelco de Bree MD (Assistant Professor of Surgery) & Dimitris D. Tsiftsis MD, PhD (Professor of Surgery and Head of Department)

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  1. Department of Surgical Oncology, Centro Oncológico MD Anderson International España, Calle Gómez Hemans 2, 28033, Madrid, Spain

    Santiago González-Moreno MD, PhD

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de Bree, E., Tsiftsis, D.D. (2007). Experimental and Pharmacokinetic Studies in Intraperitoneal Chemotherapy: From Laboratory Bench to Bedside. In: González-Moreno, S. (eds) Advances in Peritoneal Surface Oncology. Resent Results in Cancer Research, vol 169. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-30760-0_5

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