Abstract
Large blood vessels can produce localized cooling in heated tissues during tumor hyperthermia. This study has developed a Monte Carlo algorithm to simulate the cooling effect of large blood vessels during hyperthermia. Similar to previous formulations, heat transfer coefficients are used to calculate heat transfer of large blood vessels, and several typical vascular geometries are applied. The corresponding thermal model combines the Pennes bioheat transfer equation for perfused tissues and the energy equation for blood vessels with a constant Nusselt number. Using the Monte Carlo algorithm, numerical analyses are performed to test the influences of large blood vessels to the temperature distributions of tissues. The results indicate that during hyperthermia the presence of large vessels can be an important source of temperature non-uniformity and possible under-dosage. Reduction of blood flow through the large vessels is found to be an effective approach of reducing the localized cooling.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Roemer, R.B.: Engineering aspects of hyperthermia therapy. Annu. Rev. Biomed. Eng. 1, 347–376 (1999)
Chen, Z.P., Roemer, R.B.: The effects of large blood vessels on temperature distributions during simulated hyperthermia. ASME J. Biomech. Eng. 114, 473–481 (1992)
Levin, W., Sherar, M.D., Cooper, B., Hill, R.P., Hunt, J.W., Liu, F.F.: The effect of vascular occlusion on tumor temperatures during superficial hyperthermia. Int. J. Hyperther. 10, 495–505 (1994)
Crezee, J., Lagendijk, J.J.W.: Temperature uniformity during hyperthermia: the impact of large vessels. Phys. Med. Biol. 37, 1321–1337 (1992)
Koliost, M.C., Sherar, M.D., Hunt, J.W.: Large blood vessel cooling in heated tissues: a numerical study. Phys. Med. Biol. 40, 477–494 (1995)
Deng, Z.S., Liu, J.: Monte Carlo method to solve multidimensional bioheat transfer problem. Numer. Heat Tran. B. 42, 543–567 (2002)
Deng, Z.S., Liu, J.: Effects of large blood vessels on 3-D temperature distributions during simulated cryosurgery. Submitted to ASME J. Biomech. Eng. (2004)
Chato, J.C.: Heat transfer to blood vessels. ASME J. Biomech. Eng. 102, 110–118 (1980)
Chato, J.C.: Selected thermophysical properties of biological materials. In: Shitzer, A., Eberhart, E.C. (eds.) Heat Transfer in Medicine and Biology, vol. 1, pp. 413–418. Plenum Press, New York (1985)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2004 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Deng, ZS., Liu, J. (2004). Monte Carlo Simulation of the Effects of Large Blood Vessels During Hyperthermia. In: Zhang, J., He, JH., Fu, Y. (eds) Computational and Information Science. CIS 2004. Lecture Notes in Computer Science, vol 3314. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-30497-5_68
Download citation
DOI: https://doi.org/10.1007/978-3-540-30497-5_68
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-24127-0
Online ISBN: 978-3-540-30497-5
eBook Packages: Computer ScienceComputer Science (R0)