Robotic Strain Imaging for Monitoring Thermal Ablation of Liver

  • Emad M. Boctor
  • Gabor Fichtinger
  • Ambert Yeung
  • Michael Awad
  • Russell H. Taylor
  • Michael A. Choti
Part of the Lecture Notes in Computer Science book series (LNCS, volume 3217)


This report describes our initial in vitro results with robotically-assisted strain imaging for intraoperative monitoring of hepatic tumor thermal ablation. First, we demonstrate a strong correlation between thermal ablation of liver tissue and changes in elastic properties. Second, we present an experimental environment to provide controlled robotically-assisted compression of liver tissue with concurrent ultrasonic reading. Third, we present B-mode strain images of thermally treated liver samples, where the strain images corresponded to the boundaries of histologically confirmed necrosis.


  1. 1.
    Nakakura, E.K., Choti, M.A.: Management of hepatocellular carcinoma. Oncology (Huntingt) 14(7), 1085–1098 (2000); discussion 1098-102. ReviewGoogle Scholar
  2. 2.
    Buscarini, L., Rossi, S.: Technology for radiofrequency thermal ablation of liver tumors. Semin. Laparosc. Surg. 4, 96–101 (1997)Google Scholar
  3. 3.
    Boctor, E.M., Fischer, G., Choti, M.A., Fichtinger, G., Taylor, R.H.: A Dual-Armed Robotic System for Intraoperative Ultrasound Guided Hepatic Ablative Therapy:A Prospective Study. Accepted ICRA (2004) Google Scholar
  4. 4.
    Graham, S.J., Stanisz, G.J., Kecojevic, A., Bronskill, M.J., Henkelman, R.M.: Analysis of changes in MRI properties of tissues after heat treatment. Magn. Reson. Med. 42(6), 1061–1071 (1999)CrossRefGoogle Scholar
  5. 5.
    Wu, T., Felmlee, J.P., Greenleaf, J.F., Riederer, S.J., Ehman, R.L.: Assessment of thermal tissue ablation with MR elastography. Magn. Reson. Med. 45(1), 80–87 (2001)CrossRefGoogle Scholar
  6. 6.
    Kolen, A.F., Bamber, J.C., Ahmed, E.E.: Analysis of cardiovascularinduced liver motion for application to elasticity imaging of the liver in vivo. In: MIUA 2002 (2002)Google Scholar
  7. 7.
    Ophir, J., Céspedes, E.I., Ponnekanti, H., Yazdi, Y., Li, X.: Elastography: a quantitative method for imaging the elasticity of biological tissues. Ultrasonic Imag. 13, 111–134 (1991)CrossRefGoogle Scholar
  8. 8.
    Lubinski, M.A., Emelianov, S.Y., O’Donnell, M.: Speckle tracking methods for ultrasonic elasticity imaging using short time correlation. IEEE Trans. Ultrason.Ferroelect. Freq. Contr. 46, 82–96 (1999)CrossRefGoogle Scholar
  9. 9.
    Pesavento, A., Perrey, C., Krueger, M., Ermert, H.: A Time Efficient and Accurate Strain Estimation Concept for Ultrasonic Elastography Using Iterative Phase Zero Estimation. IEEE Trans. Ultrason. Ferroelect. Freq. Contr. 46(5), 1057–1067 (1999)CrossRefGoogle Scholar
  10. 10.
    Alam, S.K., Ophir, J.: Reduction of signal decorrelation from mechanical compression of tissues by temporal stretching: applications to elastography. US Med. Biol. 23, 95–105 (1997)CrossRefGoogle Scholar
  11. 11.
    Alam, S.K., Ophir, J., Konofagou, E.E.: An adaptive strain estimator for elastography. IEEE Trans. Ultrason. Ferroelec. Freq. Cont. 45, 461–472 (1998)CrossRefGoogle Scholar
  12. 12.
    Fahey, B.J., Nightingale, K.R., Wolf, P., Trahey, G.E.: ARFI Imaging of Thermal Lesions in Ex Vivo and In Vivo Soft Tissues. In: Proceedings of the 2003 IEEE US Symposium (2003)Google Scholar
  13. 13.
    Yeh, W.-C., Li, P.-C., Jeng, Y.-M., Hsu, H.-C., Kuo, P.-L., Li, M.-L., Yang, P.-M., Lee, P.H.: Elastic modulus measurements of human liver and correlation with pathology. US in Med. Biol. 28(4), 467–474 (2002)CrossRefGoogle Scholar
  14. 14.
    Doyley, M.M., Bamber, J.C., Meany, P.M., Fuechsel, F.G., Bush, N.L., Miller, N.R.: Reconstructing Young’s modulus distributions within soft tissues from freehand elastograms. Acoustical Imaging 25, 469–476 (2000)CrossRefGoogle Scholar
  15. 15.
    Taylor, R.H., Funda, J., Eldridge, B., Gruben, K., LaRose, D., Gomory, S., Talamini, M., Kavoussi, L.A., Anderson, J.H.: A Telerobotic Assistant for Laparoscopic Surgery. IEEE EMBS Magazine Special Issue on Robotics in Surgery, 279–291 (1995)Google Scholar
  16. 16.
    Moddemeijer, R.: Delay-Estimation with Application to Electroencephalograms in Epilepsy (Phd-thesis), Universiteit Twente Enschede (NL) (1989), ISBN: 90-9002668-1Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Emad M. Boctor
    • 1
  • Gabor Fichtinger
    • 1
    • 3
  • Ambert Yeung
    • 1
    • 2
  • Michael Awad
    • 2
  • Russell H. Taylor
    • 1
  • Michael A. Choti
    • 2
  1. 1.Engineering Research CenterJohns Hopkins UniversityBaltimoreUSA
  2. 2.Department of SurgeryJohns Hopkins HospitalBaltimoreUSA
  3. 3.Department of RadiologyJohns Hopkins UniversityBaltimoreUSA

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