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Long-term Effects of Childhood Cancer Therapy on Growth and Fertility

  • Michelle Reece-Mills
  • Louise E. Bath
  • Christopher J. Kelnar
  • W. Hamish B. Wallace

Abstract

Survival rates for most childhood malignancies have improved remarkably over the past decade with an overall survival rate for England and Wales for children less than 15 years of age quoted as 75% (1993 and 1997) [1]. This improvement has been attributed to advances in treatment, better supportive care, and centralizing treatment in specialized centers with entry of patients into clinical trials [2, 3]. Approximately 1 in every 640 individuals in the US between the ages of 20 and 39 years is a survivor of childhood cancer [4]. Long-term survival rates vary with cancer type, demographic characteristics such as age, gender and race, tumor characteristics such as location and extent of disease, morphology, and genetic alterations.

Keywords

Growth Hormone Thyroid Stimulate Hormone Radiat Oncol Biol Phys Childhood Cancer Fertility Preservation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 2.
    Stiller CA, Draper GJ (1998) The epidemiology of cancer in children. In: Voute PA, Kalifa C, Barrett A (eds) Cancer in children: Clinical management, 4th edn. Oxford University Press, Oxford p 3sGoogle Scholar
  2. 3.
    Stiller CA (1994) Centralized treatment, entry to trials and survival. Br J Cancer 70:352–362PubMedGoogle Scholar
  3. 4.
    National Cancer Policy Board: Weiner SI, Simone IV, Hewitt M (eds) (2003) Childhood cancer survivorship: Improving care and quality of life. National Academy of Sciences, Washington, DC 32Google Scholar
  4. 5.
    Stevens MCG, Mahler H, Parkes S (1998) The health status of adult survivors of childhood cancer. Eur J Cancer 34:694–698PubMedCrossRefGoogle Scholar
  5. 6.
    Lackner H, Benesch M, Schagerl S, et al. (2000) Prospective evaluation of late effects after childhood cancer therapy with a follow up of over 9 years. Eur J Pediatr 159:750–758PubMedCrossRefGoogle Scholar
  6. 7.
    Hudson MM, Mertens AC, Yasui Y, et al. (2003) Health status of adult long term survivors of childhood cancer: A report from the Childhood Cancer Survivors Study. JAMA 290:1583–1592PubMedCrossRefGoogle Scholar
  7. 8.
    Mertens AC, Yasui Y, Neglia JP, et al. (2001) Late mortality experience in five-year survivors of childhood and adolescent cancer: The Childhood Cancer Survivor Study. J Clin Oncol 19(13):3163–3172PubMedGoogle Scholar
  8. 9.
    Robison LL, Green D, Hudson M, et al. (2005) Long-term outcomes of adult survivors of childhood cancer: Results from the childhood cancer survivor study. Cancer 104(ll):2557–2564PubMedCrossRefGoogle Scholar
  9. 10.
    Oeffinger K, Wallace WHB (2006) Barriers to follow-up care of survivors in the United States and the United Kingdom. Pediatr Blood Cancer 46:135–142PubMedCrossRefGoogle Scholar
  10. 11.
    Kissen GDN, Wallace WHB (1995) Long-term follow up therapy based guidelines. United Kingdom Children’s Cancer Study group (UKCCSG), Pharmacia, LeicesterGoogle Scholar
  11. 12.
    Sklar CA (2001) Endocrine complications of the successful treatment of neoplastic diseases in childhood. Growth Genet Horm 17:37–42Google Scholar
  12. 13.
    Sklar CA (2002) Childhood Brain Tumours. J Pediatr Endocrinol 15(2):669–673Google Scholar
  13. 14.
    Jorgensen EV, Schwartz ID, Hvizdala E, et al. (1993) Neurotransmitter control of growth hormone secretion in children after cranial radiation therapy. J Pediatr Endocrinol 6:131–142PubMedGoogle Scholar
  14. 15.
    Schmiegelow M, Lassen S, Poulsen HS, et al. (2000) Growth hormone response to a growth hormone-releasing hormone stimulation test in a population-based study following cranial irradiation of childhood brain tumors. Horm Res 54:53–59PubMedCrossRefGoogle Scholar
  15. 16.
    Lustig RH, Schriock EA, Kaplan SL, Grumbach MM (1985) Effect of growth hormone-releasing factor on growth hormone release in children with radiation-induced growth hormone deficiency. Pediatrics 76:274–279PubMedGoogle Scholar
  16. 17.
    Saaman NA, Bakdash MM, Caderao JB, et al. (1975) Hypopituitarism after external irradiation. Evidence for both hypothalamic and pituitary origin. Ann Intern Med 83:771–777Google Scholar
  17. 18.
    Blacklay A, Grossman A, Ross RJ, et al. (1986) Cranial irradiation for cerebral and nasopharyngeal tumours in children: Evidence for the production of a hypothalamic defect in growth hormone release. J Endocrinol 108:25–29PubMedGoogle Scholar
  18. 19.
    Lam KS, Wang C, Yeung RT, et al. (1986) Hypothalamic hypopituitarism following cranial irradiation for nasopharyngeal carcinoma. Clin Endocrinol (Oxf) 24:643–651CrossRefGoogle Scholar
  19. 20.
    Pai HH, Thornton A, Katznelson L, et al. (2001) Hypothalamic/ pituitary function following high-dose conformai radiotherapy to the base of skull: Demonstration of a doseeffect relationship using dose-volume histogram analysis. Int J Radiat Oncol Biol Phys 49:1079–1092PubMedCrossRefGoogle Scholar
  20. 21.
    United Kingdom Children’s Cancer Study Group Late Effects Group. Therapy based long term follow-practice statement: Hypothalamic pituitary axis. United Kingdom Children’s Cancer Study group (UKCCSG), Pharmacia, Leicester, p 19Google Scholar
  21. 22.
    Lam KS, Tse VK, Wang C, et al. (1991) Effects of cranial irradiation on hypothalamic-pituitary function-A five year longitudinal study in patients with nasopharyngeal carcinoma. Q J Med 78(286):165–176PubMedGoogle Scholar
  22. 23.
    Littley MD, Shalet SM, Beardwell CG, et al. (1989) Hypopituitarism following external radiotherapy for pituitary tumours in adults. Q J Med 70(262):104–107Google Scholar
  23. 24.
    Clayton PE, Shalet SM (1991) Dose dependency of time of onset of radiation-induced growth hormone deficiency. J Pediatr 118:226–228PubMedCrossRefGoogle Scholar
  24. 25.
    Schmiegelow M, Lassen S, Poulsen HS, et al. (2000) Growth hormone response to a growth hormone-releasing hormone stimulation test in a population-based study following cranial irradiation of childhood brain tumors. Horm Res 54:53–59PubMedCrossRefGoogle Scholar
  25. 26.
    Spoudeas HA, Hindmarsh PC, Matthews DR, et al. (1996) Evolution of growth hormone neurosecretory disturbance after cranial irradiation for childhood brain tumours: A prospective study. J Endocrinol 150:329–342PubMedCrossRefGoogle Scholar
  26. 27.
    Shalet SM, Price DA, Gibson B, et al. (1976) The effect of varying doses of cerebral irradiation on growth hormone production in childhood. Clin Endocrinol (Oxf) 5:287–290CrossRefGoogle Scholar
  27. 28.
    Bercu BB, Diamond FB Jr (1986) Growth hormone neurosecretory dysfunction. Clin Endocrinol Metab 15:537–590PubMedCrossRefGoogle Scholar
  28. 29.
    Shalet SM, Price DA, Beardwell CG, et al. (1979) Normal growth despite abnormalities of growth hormone secretion in children treated for acute leukemia. J Pediatr 94:719–722PubMedCrossRefGoogle Scholar
  29. 30.
    Costin G (1988) Effects of low-dose cranial radiation on growth hormone secretory dynamics and hypothalamicpituitary function. Am J Dis Child 142:847–852PubMedGoogle Scholar
  30. 31.
    Shalet SM, Beardwell CG, Jones PH, et al. (1976) Growth hormone deficiency after treatment of acute leukemia in children. Arch Dis Child 51:489–493PubMedGoogle Scholar
  31. 32.
    Brennan BM, Rahim A, Mackie EM, et al. (1998) Growth hormone status in adults treated for acute lymphoblastic leukemia in childhood. Clin Endocrinol (Oxf) 48:777–783CrossRefGoogle Scholar
  32. 33.
    Kirk JA, Raghupathy P, Stevens MM, et al. (1987) Growth failure and growth-hormone deficiency after treatment for acute lymphoblastic leukemia. Lancet l(8526):190–193CrossRefGoogle Scholar
  33. 34.
    Ogilvy-Stuart AL, Clark DJ, Wallace WH, et al. (1992) Endocrine deficit after fractionated total body irradiation. Arch Dis Child 67:1107–1110PubMedGoogle Scholar
  34. 35.
    Muller HL, Klinkhammer-Schalke M, Kühl J, et al. (1998) Final height and weight of long-term survivors of childhood malignancies. Exp Clin Endocrinol Diabetes 106:135–139PubMedCrossRefGoogle Scholar
  35. 36.
    Ogilvy-Stuart AL, Shalet SM (1995) Growth and puberty after growth hormone treatment after irradiation for brain tumours. Arch Dis Child 73:141–146PubMedGoogle Scholar
  36. 37.
    Xu Weizhen, Janss A, Moshang T (2003) Adult height and adult sitting height in childhood medulloblastoma survivors. J Clin Endocrinol Metab 88(10):4677–4681PubMedCrossRefGoogle Scholar
  37. 38.
    Sulmont V, Brauner R, Fontoura M, Rappaport R (1990) Response to growth hormone treatment and final height after cranial or craniospinal irradiation. Acta Paediatr Scand Suppl 79:542–549CrossRefGoogle Scholar
  38. 39.
    de Boer H, Blok GJ, Van der Veen EA (1995) Clinical aspects of growth hormone deficiency in adults. Endocr Rev 16:63–86PubMedCrossRefGoogle Scholar
  39. 40.
    Talvensaari K, Knip M (1997) Childhood cancer and later development of the metabolic syndrome. Ann Med 29:353–355PubMedCrossRefGoogle Scholar
  40. 41.
    Kaufman JM, Taelman P, Vermeulen A, Vandeweghe M (1992) Bone mineral status in growth hormone-deficient males with isolated and multiple pituitary deficiencies of childhood onset. J Clin Endocrinol Metab 74:118–123PubMedCrossRefGoogle Scholar
  41. 42.
    Stabler B (2001) Impact of growth hormone (GH) therapy on quality of life along the life-span of GH-treated patients. Horm Res 56(1) 55–58PubMedCrossRefGoogle Scholar
  42. 43.
    Gorska, et al. (2006) Eur Soc Ped Endocrin (abstract)Google Scholar
  43. 44.
    Spoudeas HA, Hindmarsh PC, Matthews DR, Brook CG (1996) Evolution of growth hormone neurosecretory disturbance after cranial irradiation for childhood brain tumours: A prospective study. J Endocrinol 150:392–442CrossRefGoogle Scholar
  44. 45.
    Spiliotis BE, August GP, Hung W, et al. (1984) Growth hormone neurosecretory dysfunction. A treatable cause of short stature. JAMA 251:2223–2230PubMedCrossRefGoogle Scholar
  45. 46.
    Moell C, Garwicz S, Westgren U, et al. (1989) Suppressed spontaneous secretion of growth hormone in girls after treatment for acute lymphoblastic lymphoma. Arch Dis Child 64:252–258PubMedGoogle Scholar
  46. 47.
    Crowne EC, Moore C, Wallace WH, et al. (1992) A novel variant of growth hormone (GH) following low dose cranial irradiation Clin Endocrinol (Oxf) 36:59–68CrossRefGoogle Scholar
  47. 48.
    Achermann JC, Hindmarsh PC, Brook CG (1998) The relationship between the growth hormone and insulin-like growth factor axis in long-term survivors of childhood brain tumours. Clin Endocinol (Oxf) 49:639–645CrossRefGoogle Scholar
  48. 49.
    Ogilvy-Stuart AL, Ryder WD, Gattamaneni HR, et al. (1992) Growth hormone and tumour recurrence. Br Med J 304:1601–1605Google Scholar
  49. 50.
    Swerdlow AJ, Reddingius RE, Higgins CD, et al. (2000) Growth hormone treatment of children with brain tumors and risk of tumor recurrence. J Clin Endocrinol Metab 85:4444–4449PubMedCrossRefGoogle Scholar
  50. 51.
    Sklar CA, Mertens AC, Mitby P, et al. (2002) Risk of disease recurrence and second neoplasms in survivors of childhood cancer treated with growth hormone: A report from the Childhood Cancer survivor Study. J Clin Endocrinol Metab 87:3136–3141PubMedCrossRefGoogle Scholar
  51. 52.
    Sanders JE, Buckner CD, Leonard JM, et al. (1983) Late effects on gonadal function of cyclophosphamide, total-body irradiation, and marrow transplantation. Transplantation 36:252–255PubMedCrossRefGoogle Scholar
  52. 53.
    Pasqualini T, Escobar ME, Domene H, et al. (1987) Evaluation of gonadal function following long-term treatment for acute lymphoblastic leukemia in girls. Am J Pediatr Hematol Oncol 9:15–22PubMedCrossRefGoogle Scholar
  53. 54.
    Hall JE, Martin KA, Whitney HA, et al. (1994) Potential for fertility with replacement of hypothalamic gonadotrophinreleasing hormone in long term female survivors of cranial tumors. J Clin Endocrinol Metab 79:1166–1172PubMedCrossRefGoogle Scholar
  54. 55.
    Leiper AD, Stanhope R, Kitching P, et al. (1984) Precocious puberty after hypothalamic and pituitary irradiation in young children. N Engl J Med 311:920Google Scholar
  55. 56.
    Quigley C, Cowell C, Jimenez M, et al. (1989) Normal or early development of puberty despite gonadal damage in children treated for acute lymphoblastic leukemia. N Engl J Med 321:143–151PubMedCrossRefGoogle Scholar
  56. 57.
    Ogilvy-Stuart AL, Clayton PE, Shalet SM (1994) Cranial irradiation and early puberty. J Clin Endocrinol Metab 78:1282–1286PubMedCrossRefGoogle Scholar
  57. 58.
    Didock E, Davies HA, Didi M, et al. (1995) Pubertal growth in young adult survivors of childhood leukemia. J Clin Oncol 13:2503–2507Google Scholar
  58. 59.
    Davies HA, Didock E, Didi M et al. (1994) Disproportionate short stature after cranial irradiation and combination chemotherapy for leukemia. Arch Dis Child 70:472–475PubMedGoogle Scholar
  59. 60.
    Shalet SM, Gibson B, Swindell R, Pearson D (1987) Effect of spinal irradiation on growth. Arch Dis Child 62:461–464PubMedGoogle Scholar
  60. 61.
    Cara JF, Kreiter ML, Rosenfield RL (1992) Height prognosis of children with true precocious puberty and growth hormone deficiency: Effect of combination therapy with gonadotrophin releasing hormone agonist and growth hormone. J Pediatr 120:709–715PubMedCrossRefGoogle Scholar
  61. 62.
    Adan L, Souberbielle JC, Zucker JM, et al. (1997) Adult height in 24 patients treated for growth hormone deficiency and early puberty. J Clin Endocrinol Metab 82:229–233PubMedCrossRefGoogle Scholar
  62. 63.
    Van Santen HM, Vulsma T, Dijkgraaf MG, et al. (2003) No damaging effect of chemotherapy in addition to radiotherapy on the thyroid axis in young adult survivors of childhood cancer. J Clin Endocrinol Metab 88:3657–3663CrossRefGoogle Scholar
  63. 64.
    Constine LS, Woolf PD, Cann D, et al. (1993) Hypothalamic-pituitary dysfunction after radiation for brain tumors. N Engl J Med 328:87–94PubMedCrossRefGoogle Scholar
  64. 65.
    Schmiegelow M, Feldt-Rasmussen U, Rasmussen AK, et al. (2003) Assessment of the hypothalamo-pituitary-adrenal axis in patients treated with radiotherapy and chemotherapy for childhood brain tumor. J Clin Endocrinol Metab 88:3149–3154PubMedCrossRefGoogle Scholar
  65. 66.
    Hancock SL, Cox RS, McDougall IR (1991) Thyroid diseases after treatment of Hodgkin’s disease. N Engl J Med 325:599–605PubMedCrossRefGoogle Scholar
  66. 67.
    Crom DB, Kaste SC, Tubergen DG, et al. (1997) Ultrasonography for thyroid screening after head and neck irradiation in childhood cancer survivors. Med Pediatr Oncol 28:15–21PubMedCrossRefGoogle Scholar
  67. 68.
    Acharya S, Sarafoglou K, LaQuaglia M, et al. (2003)Thyroid neoplasms after therapeutic radiation for malignancies during childhood or adolescence. Cancer 97:2397–2403PubMedCrossRefGoogle Scholar
  68. 69.
    Livesey EA, Brook CG (1989) Thyroid dysfunction after radiotherapy and chemotherapy of brain tumours. Arch Dis Child 64:593–595PubMedGoogle Scholar
  69. 70.
    Paulino AC (2002) Hypothyroidism in children with medulloblastoma: A comparison of 3600 and 2340 cGy craniospinal radiotherapy. Int J Radiat Oncol Biol Phys 53:543–547PubMedGoogle Scholar
  70. 71.
    Sanders JE, Pritchard S, Mahoney S, et al. (1986) Growth and development following marrow transplantation for leukemia. Blood 68:1129–1135PubMedGoogle Scholar
  71. 72.
    Gleeson HK, Shalet SM (2004) The impact of cancer therapy on the endocrine system in survivors of childhood brain tumours. Endocr Relat Cancer 11:589–602PubMedCrossRefGoogle Scholar
  72. 73.
    Cicognani A, Pasini A, Pession A, et al: (2003) Gonadal function and pubertal development after treatment of a childhood malignancy. J Pediatr Endocrinol Metab 16:S 321–326PubMedGoogle Scholar
  73. 74.
    Kreuser ED, Xiros N, Hetzel WD, Heimpel H (1987) Reproductive and endocrine gonadal capacity in patients treated with COPP chemotherapy for Hodgkin’s disease. J Cancer Res Clin Oncol 113:260–266PubMedCrossRefGoogle Scholar
  74. 75.
    Thomson AB, Campbell AJ, Irvine DS, et al. (2002) Semen quality and spermatozoal DNA integrity in survivors of childhood cancer: A case-control study. Lancet 360:361–367PubMedCrossRefGoogle Scholar
  75. 76.
    Gerl A, Muhlbayer D, Hansmann G, et al. (2001) The impact of chemotherapy on Leydig cell function in long term survivors of germ cell tumors. Cancer 91:1297–1303PubMedCrossRefGoogle Scholar
  76. 77.
    Viviani S, Santoro A, Ragni G, et al. (1985) Gonadal toxicity after combination chemotherapy for Hodgkins disease. Comparative results of MOPP vs ABVD. Eur J Cancer Clin Oncol 21:601–605PubMedCrossRefGoogle Scholar
  77. 78.
    Waxman JH, Terry YA, Wrigley PF, et al. (1982) Gonadal function in Hodgkins disease: Long-term follow-up of chemotherapy. Br Med J (Clin Res Ed) 285:1612–1613Google Scholar
  78. 79.
    Clark ST, Radford JA, Crowther D, et al. (1995) Gonadal function following chemotherapy for Hodgkins disease: A comparative study of MVPP and a seven-drug hybrid regimen. J Clin Oncol 13:134–139PubMedGoogle Scholar
  79. 80.
    Mackie EJ, Radford M, Shalet SM (1996) Gonadal function following chemotherapy for childhood Hodgkins disease. Med Pediatr Oncol 27:74–78PubMedCrossRefGoogle Scholar
  80. 81.
    Chiarelli AM, Marrett LD, Darlington G (1999) Early menopause and infertility in females after treatment for childhood cancer diagnosed in 1964–1988 in Ontario, Canada. Am J Epidemiol 150:245–254PubMedGoogle Scholar
  81. 82.
    Whitehead E, Shalet SM, Blackledge G, et al. (1983) The effect of combination chemotherapy on ovarian function in women treated for Hodgkins disease. Cancer 52:988–993PubMedCrossRefGoogle Scholar
  82. 83.
    Speiser B, Rubin P, Cassarett G (1973) Aspermia following lower truncal irradiation in Hodgkins disease. Cancer 32:692–698PubMedCrossRefGoogle Scholar
  83. 84.
    Centola GM, Keller JW, Henzler M, Rubin P (1994) Effect of low-dose testicular irradiation on sperm count and fertility in patients with testicular seminoma. J Androl 15:608–613PubMedGoogle Scholar
  84. 85.
    Clifton DK, Bremner WJ (1983) The effect of testicular xirradiation on spermatogenesis in man. A comparison with the mouse. J Androl 4:387–392PubMedGoogle Scholar
  85. 86.
    Rowley MJ, Leach DR, Warner GA, Heller CG (1974) Effect of graded doses of ionizing radiation on the human testis. Radiat Res 59:665–678PubMedCrossRefGoogle Scholar
  86. 87.
    Shalet SM, Tsatsoulis A, Whitehead E, Read G (1989) Vulnerability of the human Leydig cell to radiation damage is dependent upon age. J Endocrinol 120:161–165PubMedGoogle Scholar
  87. 88.
    Castillo LA, Craft AW, Kernahan J, et al. (1990) Gonadal function after 12-Gy testicular irradiation in childhood acute lymphoblastic leukemia. Med Pediatr Oncol 18:185–189PubMedCrossRefGoogle Scholar
  88. 89.
    Wallace WH, Thomson AB, Saran F, et al. (2005) Predicting age of ovarian failure after radiation to a field that includes the ovaries. Int J Radiat Oncol Biol Phys 62:738–744PubMedGoogle Scholar
  89. 90.
    Wallace WHB, Thomson AB, Kelsey TW (2003) The radiosensitivity of the human oocyte. Hum Reprod 18:117–121PubMedCrossRefGoogle Scholar
  90. 91.
    Chemaitilly W, Mertens AC, Mitby P, et al. (2006) Acute ovarian failure in the childhood cancer survivor study. J Clin Endocrinol Metab 91:1723–1728PubMedCrossRefGoogle Scholar
  91. 92.
    Sanders JE, Hawley J, Levy W, et al. (1996) Pregnancies following high-dose cyclophosphamide with or without highdose busulfan or total-body irradiation and bone marrow transplantation. Blood 87:3045–3052PubMedGoogle Scholar
  92. 93.
    Bath LE, Critchley HO, Chambers SE, et al. (1999) Ovarian and uterine characteristics after total body irradiation in childhood and adolescence: Response to sex steroid replacement. Br J Obstet Gynaecol 106:1265–1272PubMedGoogle Scholar
  93. 94.
    Critchley HO, Wallace WH, Shalet SM, et al. (1992) Abdominal irradiation in childhood: The potential for pregnancy. Br J Obstet Gynaecol 99:392–394PubMedGoogle Scholar
  94. 95.
    Lushbaugh CC, Casarett GW (1976) The effects of gonadal irradiation in clinical radiation in therapy: A review. Cancer 37:1111–1125PubMedCrossRefGoogle Scholar
  95. 96.
    Wallace EM, Groome NP, Riley SC, et el. (1997) Effects of chemotherapy-induced testicular damage on inhibin, gonadotrophin, and testicular secretion: A prospective longitudinal study. J Clin Endocrinol Metab 82:3111–3115PubMedCrossRefGoogle Scholar
  96. 97.
    Crofton PM, Thomson AB, Evans AE, et al. (2003) Is inhibin B a potential marker of gonadotoxicity in prepubertal children treated for cancer? Clin Endocrinol (Oxf) 58(3):296–301CrossRefGoogle Scholar
  97. 98.
    Rosen A (2005) Third-party reproduction and adoption in cancer patients. J Natl Cancer Inst Monogr: 34:91–93PubMedCrossRefGoogle Scholar
  98. 99.
    Fossa SD, Aass N, Molne K (1989) Is routine pre-treatment cryopreservation of semen worthwhile in the management of patients with testicular cancer? Br J Urol 64:524–529PubMedGoogle Scholar
  99. 100.
    Schover LR, Brey K, Litchin A, et al. (2002) Knowledge and experience regarding cancer, infertility, and sperm banking in younger male survivors. J Clin Oncol 20:1880–1889PubMedCrossRefGoogle Scholar
  100. 101.
    Schover LR, Rybicki LA, Martin BA, et al. (1999) Having children after cancer. A pilot survey of survivors’ attitudes and experiences. Cancer 86: 697–709PubMedCrossRefGoogle Scholar
  101. 102.
    Brinster RL, Zimmerman JW (1994) Spermatogenesis following male germ-cell transplantation. Proc Natl Acad Sci USA91:11298–11302PubMedCrossRefGoogle Scholar
  102. 103.
    Schlaft S, von Schonfeldt V, Schepers AG (2000) Male germ cell transplantation: An experimental approach with a clinical perspective. Br Med Bull 56:824–836CrossRefGoogle Scholar
  103. 104.
    Newton H (1998) The cryopreservation of ovarian tissue as a strategy for preserving the fertility of cancer patients. Hum Reprod Update 4:237–247PubMedCrossRefGoogle Scholar
  104. 105.
    Lee SJ, Schover LR, Partridge AH, et al. (2006) American Society of Clinical Oncology recommendations on fertility preservation in cancer patients. J Clin Oncol 24:2917–2931PubMedCrossRefGoogle Scholar
  105. 106.
    Oktay K (2005) Further evidence on the safety and success of ovarian stimulation with letrozole and tamoxifen in breast cancer patients undergoing in vitro fertilization to cryopreserve their embryos for fertility preservation. J Clin Oncol 23:3858–3859PubMedCrossRefGoogle Scholar
  106. 107.
    Oktay K, Buyuk E, Libertella N, et al. (2005) Fertility preservation in breast cancer patients: A prospective controlled comparison of ovarian stimulation with tamoxifen and letrozole for embryo cryopreservation. J Clin Oncol 23(19):4347–4353PubMedCrossRefGoogle Scholar
  107. 108.
    Thomson AB, Campbell AJ, Irvine DC, et al. (2002) Semen quality and spermatozoal DNA integrity in survivors of childhood cancer: A case-control study. Lancet 360:361–367PubMedCrossRefGoogle Scholar
  108. 109.
    Green DM, Whittton JA, Stovall M, et al. (2002) Pregnancy outcome of female survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Am J Obstet Gynecol 187:1070–1080PubMedCrossRefGoogle Scholar
  109. 110.
    Sankila R, Olsen JH, Anderson H, et al. (1998) Risk of cancer among offspring of childhood-cancer survivors. Association of Nordic Cancer Registries and the Nordic Society of Paediatric Haematology and Oncology. N Engl J Med 338:1339–1344PubMedCrossRefGoogle Scholar
  110. 111.
    Stovall M, Donaldson SS, Weathers RE, et al. (2004) Genetic effects of radiotherapy for childhood cancer: Gonadal dose reconstruction. Int J Radiat Oncol Biol Phys 60:542–552PubMedGoogle Scholar
  111. 112.
    Green DM, Whitton JA, Stovall M, et al. (2003) Pregnancy outcomes of partners of male survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. J Clin Oncol 21:716–721PubMedCrossRefGoogle Scholar
  112. 113.
    Boice JD Jr, Tawn EJ, Winther JF, et al. (2003) Genetic effects of radiotherapy for childhood cancer. Health Phys 85:65–80PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Michelle Reece-Mills
    • 1
  • Louise E. Bath
    • 1
  • Christopher J. Kelnar
    • 1
  • W. Hamish B. Wallace
    • 2
  1. 1.Department of Paediatric OncologyRoyal Hospital for Sick ChildrenEdinburghScotland UK
  2. 2.Royal Hospital for Sick ChildrenEdinburghScotland UK

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