Liver Tumors in Children

  • Jay L. Grosfeld
  • Jean-Bernard Otte


Liver tumors in children are relatively uncommon when compared with other malignant conditions in the pediatric age group. This chapter deals with the three most common malignant liver tumors in childhood; hepatoblastoma (HB), hepatocellular carcinoma (HCC), and embryonal undifferentiated sarcoma.


Hepatocellular Carcinoma Liver Transplantation Inferior Vena Cava Hepatic Resection Liver Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Darbari A, Sabin KM Shapiro CN, Schwarz KB (2003) Epidemiology of primary hepatic malignancies in US children. Hepatology 38:560–566PubMedGoogle Scholar
  2. 2.
    McLaughlin C, Baptiste MS, Schymura MJ, et al. (2006) Maternal and infant birth characteristics and hepatoblastoma. Am J Epidemiol 163:818–828PubMedGoogle Scholar
  3. 3.
    De Ugarte DA, Atkinson JB (2006) Liver tumors. In: Grosfeld, JL, O’Neill JA Jr, Fonkalsrud EW, Coran AG (eds) Pediatric surgery, 6th edn. Mosby-Elsevier, Philadelphia, pp 502–514Google Scholar
  4. 4.
    Ding SF, Michail NE, Habib NA (1994) Genetic changes in hepatoblastoma. J Hepatol 20:672–675PubMedGoogle Scholar
  5. 5.
    Vaughan WG, Sanders DW, Grosfeld JL, et al. (1995) Favorable outcome in children with Beckwith-Wiedemann syndrome and intra-abdominal malignant tumors. J Pediatr Surg 30:1042–1044PubMedGoogle Scholar
  6. 6.
    Albrecht S, von Schweinitz D, Waha A, et al. (1994) Loss of maternal alleles on chromosome arm 11p in hepatoblastoma. Cancer Res 54:5041–5044PubMedGoogle Scholar
  7. 7.
    Bowman LC, Riely CA (1996) Management of pediatric liver tumors. Surg Oncol Clin North Am 5:451–459Google Scholar
  8. 8.
    Greenberg M, Filler RM (1993) Hepatic tumors. In: Pizzo P, Poplack D (eds) Management of common cancers of childhood. Lippincott, Philadelphia, pp 697–711Google Scholar
  9. 9.
    Tanaka K, Vemoto S, Asonume K, et al. (1997) Hepatoblastoma in a two year old girl with trisomy 18. Eur J Pediatr Surg 2:298Google Scholar
  10. 10.
    Terracciano L, Tornillo L (2003) Cytogenetic alteration in liver cell tumors as detected by comparative genomic hybridization. Pathologica 95:71–82PubMedGoogle Scholar
  11. 11.
    Buendia MA (2002) Genetic alterations in hepatoblastoma and hepatocellular carcinoma: Common and distinct aspects. Med Pediatr Oncol 39:530–535PubMedGoogle Scholar
  12. 12.
    Sanghathat S, Kusafuka T, Miao J, et al. (2006) In vitro RNA interference against beta-catenin inhibits proliferation of pediatric hepatic tumors. Int J Oncol 28:715–722Google Scholar
  13. 13.
    Chen TC, Hsieh LL, Kuo TT (1995) Absence of p53 gene mutation and infrequent overexpression of p53 protein in hepatoblastoma. J Pathol 176:243–247PubMedGoogle Scholar
  14. 14.
    Hughes LI, Michels W (1992) Risk of hepatoblastoma in familial adenomatous polyposis. Am J Med Genet 43:1023–1025PubMedGoogle Scholar
  15. 15.
    Garber JE, Li FP, Kingston JE, et al. (1988) Hepatoblastoma and familial adenomatous polyposis. J Natl Cancer Inst 80:1626–1628PubMedGoogle Scholar
  16. 16.
    Thomas D, Pritchard J, Davidson R, et al. (2003) Familial hepatoblastoma and APC gene mutations: Renewed call for molecular research. Eur J Cancer 39:2200–2204PubMedGoogle Scholar
  17. 17.
    Geiger JD (1996) Surgery for hepatoblastoma in children. Curr Opin Pediatr 276–282Google Scholar
  18. 18.
    Otten J, Smets R, De Jager R, et al. (1977) Hepatoblastoma in an infant after contraceptive intake during pregnancy. New Engl J Med 297:222PubMedGoogle Scholar
  19. 19.
    Kahn A, Bader L, Hoy GR, Sinks LF (1979) Hepatoblastoma in a child with fetal alcohol syndrome. Lancet 1:1403–1404Google Scholar
  20. 20.
    Hashizumi K, Nakajo T, Kawarasaki H, et al. (1991) Prader-Willi syndrome with deletion of 15q11, ql3 associated hepatoblastoma. Acta Pediatr Jpn 33:718–722Google Scholar
  21. 21.
    Richter A, Grabhorn E, Schulz A, et al. (2005) Hepatoblastoma in a child with progressive familial intrahepatic cholestasis. Pediatr Transplant 9:805–808PubMedGoogle Scholar
  22. 22.
    Ikeda H, Matsuyama S, Tanimura M (1997) Association between hepatoblastoma and very low birth weight: A trend or chance? J Pediatr 130:557–560PubMedGoogle Scholar
  23. 23.
    Ross J (1997) Hepatoblastoma and birth weight: Too little, too big, or just right? J Pediatr 130:516–517PubMedGoogle Scholar
  24. 24.
    Pang D, McNally R, Birch JM (2003) Parental smoking and childhood cancer: Results from the United Kingdom Childhood Cancer Study. Br J Cancer 88:373–381PubMedGoogle Scholar
  25. 25.
    Sorahan T, Lancashire RJ (2004) Parental cigarette smoking and childhood risk of hepatoblastoma: OSCC data. Br J Cancer 90:1016–1018PubMedGoogle Scholar
  26. 26.
    Ammann RA, Plaschkes J, Leibundgut K (1999) Congenital hepatoblastoma: A distinct entity? Med Pediatr Oncol 32:466–468PubMedGoogle Scholar
  27. 27.
    Sinta L, Freud N, Dulitzki F (1992) Hemoperitoneum as the presenting sign of hepatoblastoma in the newborn. Pediatr Surg Int 7:131–133Google Scholar
  28. 28.
    Perilongo G, Shafford E, Maibach R, et al. (2004) Risk-adapted treatment for childhood hepatoblastoma. Final report of the second study of the International Society of Pediatric Oncology-SIOPEL 2. Eur J Cancer 40:411–421PubMedGoogle Scholar
  29. 29.
    Brown J, Perilongo G, Shafford E, et al. (2000) Pretreatment prognostic factors for children with hepatoblastoma-results from the International Society of Paediatric Oncology (SIOP) study SIOPEL 1. Eur J Cancer 36:1418–1425PubMedGoogle Scholar
  30. 30.
    Schnater JM, Aronson DC, Plaschkes J, et al. (2002) Surgical view of the treatment of patients with hepatoblastoma: Results from the first prospective trial of the International Society of Pediatric Oncology Liver Tumor Study Group. Cancer 94:1111–1120PubMedGoogle Scholar
  31. 31.
    Czauderna P, Otte JB, Pritchard J, et al. (2005) Guidelines for surgical treatment of hepatoblastoma in the modern era. Recommendations from the Childhood Liver Tumor Strategy Group (SIOPEL) of the International Society of Pediatric Oncology (SIOP). Eur J Cancer 41:1031–1036PubMedGoogle Scholar
  32. 32.
    Wang JN, Chen JS, Chung Y, et al. (2002) Invasion of the cardiovascular system in childhood malignant hepatic tumors. J Pediatr Hematol Oncol 24:436–439PubMedGoogle Scholar
  33. 33.
    Zimmermann A (2005) The emerging family of hepatoblastoma tumours: From ontogenesis to oncogenesis. A review. Eur J Cancer 1:1503–1514Google Scholar
  34. 34.
    Haas JE, Muzsynski KA, Krailo M, et al. (1989) Histopathology and prognosis in childhood hepatoblastoma and hepatocarcinoma. Cancer 4:1082–1095Google Scholar
  35. 35.
    Ortega JA, Douglass EC, Feusner JH, et al. (2000) Randomized comparison of cisplatin/vincristine/fluorouracil/cisplatin/continuous infusion doxorubicin for treatment of pediatric hepatoblastoma: A report from the Children’s Cancer Group and the Pediatric Oncology Group. J Clin Oncol 18:2665–2675PubMedGoogle Scholar
  36. 36.
    von Schweinitz D, Byrd DJ, Hecker H, et al. (1997) Efficiency and toxicity of ifosfamide, cisplatin and doxorubicin in the treatment of childhood hepatoblastoma. Study Committee of the Cooperative Paediatric Liver Tumour Study HB89 of the German Society for Paediatric Oncology and Haematology. Eur J Cancer 33:1243–1249Google Scholar
  37. 37.
    Couinaud C (1954) Basis anatomiques des hepatectomies gauche et drought regies: Techniques qui en decoulent. J Chir (Paris) 70:933–936Google Scholar
  38. 38.
    Aronson D, Schnater JM, Staalman C, et al. (2005) The predictive value of the PRETreatment EXTent of disease (PRETEXT) system in hepatoblastoma: Results from the International Society of Pediatric Oncology Liver Tumor Study Group (SIOPEL-1). J Clin Oncol 23:1245–1252PubMedGoogle Scholar
  39. 39.
    Roebuck D, Aronson A, Clapuyt P, et al. (2005) PRETEXT: A revised staging system for primary malignant liver tumors of childhood. Pediatr Radiol 2007; 37:123–132PubMedGoogle Scholar
  40. 40.
    Meyers RL, Malogolowkin MH, Rowland JM, Krailo M (2006) Predictive value of the PRETEXT staging system in children with hepatoblastoma. Presented at the 37th annual meeting American Pediatric Surgical Association, Hilton Head, SC, May 27, 2006Google Scholar
  41. 41.
    Stringer M (2000) Liver tumors. Semin Pediatr Surg 9:196–208PubMedGoogle Scholar
  42. 42.
    Fuchs J, Rydzynski J, Hecker H, et al. (2002) The influence of preoperative chemotherapy and surgical technique in the treatment of hepatoblastoma—A report from the German Cooperative Liver Tumours Studies HB-89 and HB-94. Eur J Pediatr Surg 12:255–261PubMedGoogle Scholar
  43. 43.
    von Schweinitz D, Faundez A, Teichmann B, et al. (2000) Hepatocyte growth-factor-scatter-factor can stimulate postoperative tumor-cell proliferation in childhood hepatoblastoma. Int J Cancer 85:151–159Google Scholar
  44. 44.
    von Schweinitz D, Hecker H, Harms D, et al. (1995) Complete resection before development of drug resistance is essential for survival from advanced hepatoblastoma-a report from the German Cooperative Pediatric Liver Tumor Study HB-89. J Pediatr Surg 30:845–852Google Scholar
  45. 45.
    Finegold M (2002) Chemotherapy for suspected hepatoblastoma without effort at surgical resection is bad practice. Med Pediatr Oncol 39:484–486PubMedGoogle Scholar
  46. 46.
    Ortega JA, Krailo MD, Haas JE, et al. (1991) Effective treatment of unresectable or metastatic hepatoblastoma with cisplatin and continuous infusion doxorubicin chemotherapy: A report from the Children Cancer Study Group. J Clin Oncol 9:2167–2176PubMedGoogle Scholar
  47. 47.
    Douglass EC, Reynolds M, Finegold M, Cantor AB, Glycksman A (1993) Cisplatin, vincristine, and fluorouracil therapy for hepatoblastoma: A Pediatric Oncology Group study. J Clin Oncol 11:96–99PubMedGoogle Scholar
  48. 48.
    Ortega JA, Douglass E, Feusner J, et al. (1994) A randomized trial of cisplatin/vincristine/5-fluorouracil vs. CCP/doxorubicin continuous infusion for the treatment of hepatoblastoma: Results from the Pediatric Inter-Group Hepatoma Study (abstr). Proc Am Soc Clin Oncol (ASCO) 13:416Google Scholar
  49. 49.
    Grosfeld, JL (1998) Hepatoblastoma and hepatocellular carcinoma. In: Carachi R, Azmy A, Grosfeld, JL (eds) Surgery of childhood tumors. Arnold, London, pp 178–198Google Scholar
  50. 50.
    LaQuaglia MP, Shorter NM, Blumgart LH (2002) Central hepatic resection for pediatric tumors. J Pediatr Surg 37:986–989Google Scholar
  51. 51.
    Reynolds M (1995) Conversion of unresectable to resectable hepatoblastoma and long term follow up. World J Surg 19:814–816PubMedGoogle Scholar
  52. 52.
    King DR, Ortega J, Campbell J, et al. (1991) Surgical management of children with incompletely resected hepatic cancer facilitated by intensive chemotherapy. J Pediatr Surg 26:1074–1081PubMedGoogle Scholar
  53. 53.
    Haberle B, Bode U, von Schweinitz D (2003) Differentiated treatment protocols for high and standard risk hepatoblastoma-an interim report of the German Liver Tumor Study HB99. Klin Pediatr 215:159–165Google Scholar
  54. 54.
    Dall’Igna P, Cecchetto G, Toffolutti T, et al. (2003) Multifocal hepatoblastoma is there a place for partial hepatectomy? Med Pediatr Oncol 40:113–116PubMedGoogle Scholar
  55. 55.
    von Schweinitz D (2006) Management of liver tumors in childhood. Semin Pediatr Surg 15:17–24Google Scholar
  56. 56.
    Pritchard J, Brown J, Shafford E, et al. (2000) Cisplatin, doxorubicin and delayed surgery for childhood hepatoblastoma: A successful approach-results of the first prospective study of the International Society of Pediatric Oncology. J Clin Oncol 18:3819–3828PubMedGoogle Scholar
  57. 57.
    Couinaud C (1992) The anatomy of the liver. Ann Ital Chir 63:693–697PubMedGoogle Scholar
  58. 58.
    Wheatley JM, Rosenfield NS, Berger L, LaQuaglia MP (1996) Liver regeneration in children after major hepatectomy for malignancy-evaluation using a computer-aided technique of volume measurement. J Surg Res 61:183–189PubMedGoogle Scholar
  59. 59.
    Otte JB, Pritchard J, Aronson DC, et al. (2004) Liver transplantation for hepatoblastoma: Results from the International Society of Pediatric Oncology (SIOP) study SIOPEL-1 and review of the world experience. Pediatr Blood Cancer 42:74–83PubMedGoogle Scholar
  60. 60.
    Otte JB, de Ville de Goyet J, Reding R (2005) Liver transplantation for hepatoblastoma: Indications and contraindications in the modern era. Pediatr Transplant 9:557–565PubMedGoogle Scholar
  61. 61.
    Austin MT, Leys CM, Feurer ID, et al. (2006) Liver transplantation for childhood hepatic malignancy: A review of the United Network for Organ Sharing (UNOS) database. J Pediatr Surg 41:182–186PubMedGoogle Scholar
  62. 62.
    Pimpalwar AP, Sharif K, Ramani P, et al. (2002) Strategy for hepatoblastoma management: Transplant versus nontransplant surgery. J Pediatr Surg 37:240–245PubMedGoogle Scholar
  63. 63.
    Otte JB, de Ville de Goyet J (2005) The contribution of transplantation to the treatment of liver tumors in children. Semin Pediatr Surg 14:233–238PubMedGoogle Scholar
  64. 64.
    Otte JB, Meyers R (2006) Correspondence. J Pediatr Surg 41:607–608PubMedGoogle Scholar
  65. 65.
    Chardot C, Saint-Martin C, Gilles A, et al. (2002) Living-related liver transplantation and vena cava reconstruction after total hepatectomy including the vena cava for hepatoblastoma. Transplantation 73:90–92PubMedGoogle Scholar
  66. 66.
    Reyes JD, Carr B, Dvorchik I, et al. (2000) Liver transplantation and chemotherapy for hepatoblastoma and hepatocellular carcinoma in childhood and adolescence. J Pediatr 136:795–804PubMedGoogle Scholar
  67. 67.
    Perilongo G, Brown J, Shafford E, et al. (2000) Hepatoblastoma presenting with lung metastases: Treatment results of the first cooperative, prospective study of the International Society of Pediatric Oncology on childhood liver tumors. Cancer 89:1845–1853PubMedGoogle Scholar
  68. 68.
    Otte JB, Rosati R, Janssen M (2004) Parental experience with life-related donor liver transplantation. Pediatr Transplant 8:317–321PubMedGoogle Scholar
  69. 69.
    Stringer MD, Hennayake S, Howard ER, et al. (1995) Improved outcome for children with hepatoblastoma. Brit J Surg 82:386–391PubMedGoogle Scholar
  70. 70.
    Srinivasan P, McCall J, Pritchard J, et al. (2002) Orthotopic liver transplantation for unresectable hepatoblastoma. Transplantation 74:652–655PubMedGoogle Scholar
  71. 71.
    Molmenti EP, Wilkinson K, Moment H, et al. (2002) Treatment of unresectable hepatoblastoma with liver transplantation in the pediatric population. Am J Transplant 2:535–538PubMedGoogle Scholar
  72. 72.
    Mejia A, Lagans A, Shaw BW, et al. (2005) Living and deceased donor liver transplantation for unresectable hepatoblastoma at a single centre. Clin Transplant 19:721–725PubMedGoogle Scholar
  73. 73.
    Sasaki F, Matsunaga T, Iwafuchi M, et al. (2003) Outcome of hepatoblastoma treated with the JPLT-1 (Japanese Study Group for Pediatric Liver Tumor) Protocol-1:A report from the Japanese Study Group for Pediatric Liver Tumor. J Pediatr Surg 37:851–856Google Scholar
  74. 74.
    Fuchs J, Rydzynski J, von Schweinitz D, et al. (2002) Pretreatment prognostic factors and treatment results in children with hepatoblastoma: A report from the German Cooperative Pediatric Liver Tumor Study HB-94. Cancer 95:172–182PubMedGoogle Scholar
  75. 75.
    Parker SL, Tong T, Bolden S, Wingo PA (1996) Cancer statistics 1996. CA Cancer J Clin 46:5–27PubMedGoogle Scholar
  76. 76.
    Cusnir M, Patt YZ (2004) Novel systemic therapy options for hepatocellular carcinoma. Cancer J 10:97–103PubMedGoogle Scholar
  77. 77.
    El-Serag HB (2001) Epidemiology of hepatocellular carcinoma. Clin Liver Dis 5:87–107PubMedGoogle Scholar
  78. 78.
    O’Brien TR, Kirk G, Zhang M (2004) Hepatocellular carcinoma: A paradigm of preventive oncology. Cancer J 10:67–73PubMedGoogle Scholar
  79. 79.
    Moore SW, Millar AJ, Hadley GP, et al. (2004) Hepatocellular carcinoma and liver tumors in South African children: A case for increased prevalence. Cancer 101:642–649PubMedGoogle Scholar
  80. 80.
    Hadley GP, Govender D, Landres G, et al. (2004) Primary tumors of the liver in children: An African perspective. Pediatr Surg Int 20:314–318PubMedGoogle Scholar
  81. 81.
    Malogolowkin MH, Zimmerman A, Plashkes J. Liver tumors in adolescents and young adults, (in press)Google Scholar
  82. 82.
    Czauderna P, MacKinley G, Perilongo G, et al. (2002) Hepatocellular carcinoma in children: Results of the first prospective study of the International Society of Pediatric Oncology Group. J Clin Oncol 20:2798–2804PubMedGoogle Scholar
  83. 83.
    Chang MH, Chen CJ, Lai MS, et al. (1997) Universal Hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. Taiwan Childhood Hepatoma Study group. N Engl J Med 336:1855–1859PubMedGoogle Scholar
  84. 84.
    Tsai HL, Liu CS, Chin TW, et al. (2004) Hepatoblastoma and hepatocellular carcinoma in children. J Chin Med Assoc 67:83–88PubMedGoogle Scholar
  85. 85.
    LaBerge JM (2003) Liver tumors. In: O’Neill JA Jr, Grosfeld, JL, Fonkalsrud EW, et al. (eds) Principles of pediatric surgery, 2nd edn. Mosby, St Louis, pp 239–247Google Scholar
  86. 86.
    Pawlik TM, Scroggins CR, Thomas MB, Vauthey J-N (2004) Advances in the surgical management of liver malignancies. Cancer J 10:74–87PubMedGoogle Scholar
  87. 87.
    El-Serag, HB, Mason MC (1999) Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med 340:743–750Google Scholar
  88. 88.
    El-Serag HB (2004) Hepatocellular carcinoma: Recent trends in the United States. Gastroenterology 127(Suppl 1): S27–S34PubMedGoogle Scholar
  89. 89.
    Van Spronson FJ, Bijleveldem M, van Maldegem BT, Wijburg IA (2005) Hepatocellular carcinoma in hereditary tyrosinemia type 1 despite 2(-2 nitro 4-3 trifluoro-methyl-benzenyl)l-3 cyclohexanedione therapy. J Pediatr Gastroenterol Nutr 40:90–93Google Scholar
  90. 90.
    Bianchi L (1993) Glycogen storage disease I and hepatocellular tumors. Eur J Pediatr 152(Suppl 1):S63–S70PubMedGoogle Scholar
  91. 91.
    Franco LM, Krishnamurthy V, Bali D, et al. (2005) Hepatocellular carcinoma in Glycogen storage disease type la: A case series. J Inherit Metab Dis 28:153–162PubMedGoogle Scholar
  92. 92.
    Hadzic N, Quaglia A, Mieli-Vergani G (2006) Hepatocellular carcinoma in a 12 year old child with PiZZ alpha-1-antityrpsin deficiency. Hepatology 43:194–196PubMedGoogle Scholar
  93. 93.
    Halvorsen RA J, Garrity S, Kun C, et al. (1995) Coexisting hepatocellular carcinoma in a patient with arteriohepatic dysplasia. Abdom Imaging 20:191–196PubMedGoogle Scholar
  94. 94.
    Bhadri VA, Storman MO, Arbuckle S, et al. (2005) Hepatocellular carcinoma in children with Alagille’s syndrome. J Pediatr Gastroenterol Nutr 51:676–678Google Scholar
  95. 95.
    Pennington DJ, Sivit CJ, Chandra RS (1996) Hepatocellular carcinoma in a child with Niemann-Pick disease: Imaging findings. Pediatr Radiol 26:220–221PubMedGoogle Scholar
  96. 96.
    Esquivel CO, Gutierrez C, Cox KL, et al. (1999) Hepatocellular carcinoma and liver cell dysplasia in children with chronic liver disease. J Pediatr Surg 29:1465–1469Google Scholar
  97. 97.
    Janes CH, McGill DB, Ludwig J, Krom RA (1993) Liver adenoma at age three years and transplantation later after development of carcinoma. Hepatology 17:583–585PubMedGoogle Scholar
  98. 98.
    Pichon N, Maisonette F, Pichon-Lefievre F, et al. (2003) Hepatocellular carcinoma with congenital agenesis of the portal vein. Jpn J Clin Oncol 33:314–316PubMedGoogle Scholar
  99. 99.
    Gruner BA, DeNapoli TS, Andrews W, et al. (2000) Hepatocellular carcinoma in children associated with Gardner’s syndrome or familial adenomatous polyposis. J Pediatr Hematol Oncol 22:90–91Google Scholar
  100. 100.
    Ghaferi AA, Hutchins GM (2005) Progression of liver pathology in patients undergoing the Fontan procedure: Chronic passive congestion, cardiac cirrhosis, hepatic adenoma and hepatocellular carcinoma. J Thorac Cardiovasc Surg 129:1348–1352PubMedGoogle Scholar
  101. 101.
    Moore L, Bourne AJ, Preston H, Byard RW (1997) Hepatocellular carcinoma following neonatal hepatitis. Pediatr Pathol Lab Med 17:601–610PubMedGoogle Scholar
  102. 102.
    Kohno N, Kitatani H, Wada H, et al. (1995) Hepatocellular carcinoma complicating biliary cirrhosis caused by biliary atresia. J Pediatr Surg 30:1713–1716PubMedGoogle Scholar
  103. 103.
    Whitington PF, Freese DK, Alonso EM, et al. (1994) Clinical and biochemical findings in progressive familial intrahepatic cholestasis. J Pediatr Gastroenterol Nutr 18:134–141PubMedGoogle Scholar
  104. 104.
    Knisley AS, Strautnieks SS, Meier Y, et al. (2006) Hepatocellular carcinoma in 10 children under 5 years of age with bile salt export pump deficiency. Hepatology 44:478–486Google Scholar
  105. 105.
    Scheers I, Badry V, Stephenne X, Sokal EM (2005) Risk of hepatocellular carcinoma in liver mitochondrial respiratory chain disorders. J Pediatr 141:414–417Google Scholar
  106. 106.
    Maitra A, Ramnanai DM, Margraf LR, Gazdar AF (2000) Synchronous Wilms’ tumor and fibrolamellar hepatocellular carcinoma in a four year old boy. Pediatr Dev Pathol 3:492–496PubMedGoogle Scholar
  107. 107.
    Jain D, Hui P, McNamara J, Schwartz D (2001) Bloom syndrome in siblings: First reports of hepatocellular carcinoma and Wilms’ tumor with documented anaplasia and nephrogenic rests. Pediatr Dev Pathol 4:585–589PubMedGoogle Scholar
  108. 108.
    Kovalik JJ, Thomas PRM, Thomas MB, et al. (1991) Hepatocellular carcinoma as second malignant neoplasms in successfully treated Wilms’ tumor patients. Cancer 67:342–344Google Scholar
  109. 109.
    Hartley AL, Dirch JM, Blair V, et al. (1994) Second primary neoplasms in a population based series of patients diagnosed with renal tumors in childhood. Med Pediatr Oncol 22:318–322PubMedGoogle Scholar
  110. 110.
    Kumari TP, Shanvas A, Mathews A, Kusumackomary P (2000) Hepatocellular carcinoma: A rare late event in childhood acute lymphocytic leukaemia. J Pediatr Hematol Oncol 22:289–290PubMedGoogle Scholar
  111. 111.
    Strickland DK, Jenkins JJ, Hudson MM (2001) Hepatitis C infection and hepatocellular carcinoma after treatment of childhood cancer. J Pediatr Hematol Oncol 23:527–529PubMedGoogle Scholar
  112. 112.
    Saurin JC, Taniere P, Mion F, et al. (1997) Primary hepatocellular carcinoma in workers exposed to vinyl chloride: Report of two cases. Cancer 79:1671–1677PubMedGoogle Scholar
  113. 113.
    Mays ET, Christopherson W (1984) Hepatic tumors induced by sex steroids. Semin Liver Dis 4:147–157PubMedGoogle Scholar
  114. 114.
    Mendishona E, MacPhail AP, Gordeyk VR, et al. (1998) Dietary iron overload as a risk factor for hepatocellular carcinoma in Black Africans. Hepatology 27:1563–1566Google Scholar
  115. 115.
    Pang A, Ng, IO, Fan ST, Kwong YL (2003) Clinicopathologic significance of genetic alterations in hepatocellular carcinoma. Cancer Genet Cytogenet 146:8–15PubMedGoogle Scholar
  116. 116.
    Kusafuka T, Fukuzawa M, Oue T, et al. (1997) Mutation analysis of p53 gene in childhood malignant solid tumor. J Pediatr Surg 32:1175–1180PubMedGoogle Scholar
  117. 117.
    Yu SB, Kim HY, Eo H, et al. (2006) Clinical characteristics and prognosis of pediatric hepatocellular carcinoma. World J Surg 30:43–50PubMedGoogle Scholar
  118. 118.
    Sachdeva R. Yapor M, Schwersenz A, et al. (1993) Massive variceal bleeding caused by a hepatic artery-portal vein fistula: A manifestation of hepatocellular carcinoma in a 12 year old. J Pediatr Gastroenterol Nutr 16:468–471PubMedGoogle Scholar
  119. 119.
    Hany MA, Betts DR, Schmugge M, et al. (1997) A childhood fibrolamellar hepatocellular carcinoma with increased aromatase activity and a near triploid karyotype. Med Pediatr Oncol 28:136–138PubMedGoogle Scholar
  120. 120.
    Kane SP, Murray-Lyon IM, Paradinas FJ, et al. (1978) Vitamin B12 binding protein as a tumor marker for hepatocellular carcinoma. Gut 19:1105–1109PubMedGoogle Scholar
  121. 121.
    Paradinas FJ, Melia WM, Wilkinson ML, et al. (1982) High serum vitamin B12 binding capacity as a marker of fibrolamellar variant of hepatocellular carcinoma. Br Med J 25:840–842Google Scholar
  122. 122.
    Hemming AW, Scudamore OH, Shackledon CR, et al. (1992) Iodocyanine green clearance as a predictor of successful hepatic resection in cirrhotic patients. Am J Surg 163:515–518PubMedGoogle Scholar
  123. 123.
    Cormier JN, Thomas KT, Chari RS, Pinson CW (2006) Management of hepatocellular carcinoma. J Gastrointest Surg 10:761–780PubMedGoogle Scholar
  124. 124.
    Redaelli CA, Dufour JF, Wagner M, et al. (2002) Preoperative galactose elimination capacity predicts complications and survival after hepatic resection. Ann Surg 235:77–85PubMedGoogle Scholar
  125. 125.
    Wudel LJ Jr, Delbeke D, Morris D, et al. (2003) The role of [18F] fluorodeoxyglucose positron emission tomography imaging in the evaluation of hepatocellular carcinoma. Am J Surg 69:117–124Google Scholar
  126. 126.
    Hain SF, Fogelman I (2004) Recent advances in imaging hepatocellular carcinoma: Diagnosis, staging and response assessment functional imaging. Cancer J 10:121–127PubMedGoogle Scholar
  127. 127.
    Shoup M, Gonen M, D’Angelica M, et al. (2003) Volumetric analysis predicts hepatic dysfunction in patients undergoing major liver resection. J Gastrointest Surg 7:325–330PubMedGoogle Scholar
  128. 128.
    Weitz J, D’Angelica M, Jernagen W, et al. (2004) Selective use of diagnostic laparoscopy before planned hepatectomy for patients with hepatocellular carcinoma. Surgery 135:273–281PubMedGoogle Scholar
  129. 129.
    Klein MM, Molmenti EP, Colombani PM, et al. (2005) Primary liver carcinoma in people younger than 30 years. Am J Clin Pathol 124:512–518PubMedGoogle Scholar
  130. 130.
    Lauwers GY, Terris B, Balis VJ, et al. (2002) Prognostic histologic indicators of curatively resected hepatocellular carcinomas: A multi-institutional analysis of 425 patients with definition of a histologic prognostic index. Am J Surg Pathol 26:25–34PubMedGoogle Scholar
  131. 131.
    Wilkens L, Bredt M, Flemming P, et al. (2000) Cytogenetic aberrations in primary and recurrent fibrolamellar hepatocellular carcinoma detected by comparative genomic hybridization. Am J Clin Pathol 114:867–874PubMedGoogle Scholar
  132. 132.
    Prokurat A, Kluge P, Kosciesza A, et al. (2002) Transitional liver cell tumors (TLCT) in older children and adolescents: A novel group of aggressive hepatic tumors expressing beta-catenin. Med Pediatr Oncol 39:510–518PubMedGoogle Scholar
  133. 133.
    Peng SY, Chin WJ, Lai PL, et al. (2005) High alpha fetoprotein level correlates with high stage, early recurrence and poor prognosis of hepatocellular carcinoma: Significance of hepatitis virus infection, age, p53 and beta-catenin mutations. Int J Cancer 112:44–50Google Scholar
  134. 134.
    Postovsky S, Elapid R, Otte GB, et al. (2001) Late recurrence of combined hepatocellular carcinoma and hepatoblastoma in a child: Case report and review of the literature. Eur J Pediatr Surg 11:61–65PubMedGoogle Scholar
  135. 135.
    Postovsky S, Elapid R, Ben-Rush MW, et al. (2001) Local dissemination of hepatocellular carcinoma in a child after fine needle aspiration. Med Pediatr Oncol 36:667–668PubMedGoogle Scholar
  136. 136.
    Okuda K, Ohtsuki T, Obata H, et al. (1985) Natural history of hepatocellular carcinoma and prognosis in relation to treatment: Study of 850 patients. Cancer 56:918–928PubMedGoogle Scholar
  137. 137.
    Llovet JM, Bru C, Bruix J (1999) Prognosis of hepatocellular carcinoma: The BCLC staging classification. Semin Liver Dis 19:329–338PubMedGoogle Scholar
  138. 138.
    The Cancer of the Liver Italian Program (CLIP) Investigators (2000) Prospective validation of the CLIP score: A new prognostic system for patients with cirrhosis and hepatocellular carcinoma. Hepatology 31:840–845Google Scholar
  139. 139.
    Vauthey JN, Lauwers GY, Esnaola NF, et al. (2002) Simplified staging for hepatocellular carcinoma. J Clin Oncol 20:1527–1536PubMedGoogle Scholar
  140. 140.
    Levy I, Sherman M (2002) Staging of hepatocellular carcinoma: Assessment of CLIP, Okuda, and Child-Pugh staging systems in a cohort of 257 patients in Toronto. Gut 50:881–885PubMedGoogle Scholar
  141. 141.
    Helton WS, Strasberg SM: AHPBA/AJCC Consensus Conference on staging of hepatocellular carcinoma: Rationale and overview of the conference. HPB 2003:5:230–242Google Scholar
  142. 142.
    Henderson JM, Sherman M, Tavill A, et al. (2003) AHPBA/AJCC Consensus Conference on staging hepatocellular carcinoma: Consensus statement. HPB 5:243–250PubMedGoogle Scholar
  143. 143.
    Zhao WH, Ma ZM, Zhou XC, et al. (2002) Prediction of recurrence and prognosis in patients with hepatocellular carcinoma after resection by use of the CLIP score. World J Gastroenterol 8:237–242PubMedGoogle Scholar
  144. 144.
    Green F, Page D, Fleming I, et al. (2002) Cancer staging handbook, 6th edn. Springer-Verlag, New York, pp 131–144Google Scholar
  145. 145.
    Katzenstein H, Krailo MD, Malogolowkin MH, et al. (2002) Hepatocellular carcinoma in children and adolescents: Results from the Pediatric Oncology Group and the Children’s Cancer Group Intergroup Study. J Clin Oncol 20:2789–2797PubMedGoogle Scholar
  146. 146.
    Katzenstein HM, Krailo MD, Malogolowkin MH, et al. (2003) Fibrolamellar hepatocellular carcinoma in children and adolescents. Cancer 97:2006–2012PubMedGoogle Scholar
  147. 147.
    von Schweinitz D (2004) Treatment of liver tumors in children. In: Clavian PA, Fong Y, Lyerly H, et al. (eds) Liver tumors: Current and emerging therapies. Jones and Bartlett, Boston, pp 409–426Google Scholar
  148. 148.
    Shimada M, Takenada K, Gion T, et al. (1996) Prognosis of recurrent hepatocellular carcinoma: A 10-year surgical experience in Japan. Gastroenterol 111:720–726Google Scholar
  149. 149.
    Yeh CN, Lee WC, Jena LB, et al. (2002) Spontaneous tumor rupture and prognosis in patients with hepatocellular carcinoma. Br J Surg 89:1125–1129PubMedGoogle Scholar
  150. 150.
    Buczkowski AK, Kim PT, Ho SD, et al. (2006) Multidisciplinary management of ruptured hepatocellular carcinoma. J Gastrointest Surg 10:379–386PubMedGoogle Scholar
  151. 151.
    Mathurin P, Raynard B, Dharancy S, et al. (2003) Metaanalysis evaluation of adjuvant therapy after curative liver resection for hepatocellular carcinoma. Ailment Pharmacol Ther 17:1247–1261Google Scholar
  152. 152.
    Shen DW, Lu YG, Chin KV, et al. (1991) Human hepatocellular carcinoma cell lines exhibiting multidrug resistance unrelated to MRD-1 gene expression. J Cell Sci 98:317–322PubMedGoogle Scholar
  153. 153.
    Ahn SI, Seo JM, Shim SH, et al. (2001) Hepatocellular carcinoma and lung metastases in a nine year old boy. J Pediatr Surg 36:1599–1601PubMedGoogle Scholar
  154. 154.
    Klintmalm GB (1998) Liver transplantation for hepatocellular carcinoma: A registry report of the impact of tumor characteristics on outcome. Ann Surg 228:479–490PubMedGoogle Scholar
  155. 155.
    Mazzaferro V, Regalia E, Doci R, et al. (1996) Liver transplantation for the treatment of small hepatocellular carcinoma in patients with cirrhosis. New Engl J Med 334:693–699PubMedGoogle Scholar
  156. 156.
    Llovet JM, Fuster J, Bruix J (1999) Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: Resection versus transplantation. Hepatology 30:1434–1440PubMedGoogle Scholar
  157. 157.
    Wudel L, Chapman W (2003) Indications and limitations of liver transplantation for hepatocellular carcinoma. Surg Oncol Clin North Am 12:77–90Google Scholar
  158. 158.
    Bismuth H, Majno PE, Adam R (1999) Liver transplantation for hepatocellular carcinoma. Semin Liver Dis 19:311–322PubMedGoogle Scholar
  159. 159.
    Jonas S, Bechstein WO, Steinmuller T, et al. (2001) Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis. Hepatology 33:1080–1086PubMedGoogle Scholar
  160. 160.
    Kamath PS, Wiesner RH, Malinchoc M, et al. (2001) A model to predict survival in patients with end-stage liver disease. Hepatology 33:464–470PubMedGoogle Scholar
  161. 161.
    Cholongitas E, Papatheodoris GV, Vangeli M (2005) Systemic review: The model for end-stage liver disease—Should it replace Child-Pugh classification for assessing prognosis in cirrhosis. Ailment Pharmacol Ther 22:1079–1089Google Scholar
  162. 162.
    Patt CH, Thuluvath PJ (2002) Role of liver transplantation in the management of hepatocellular carcinoma. J Vasc Interv Radiol 13:S205–S210PubMedGoogle Scholar
  163. 163.
    Yao FY, Ferrell L, Bass NM, et al. (2001) Liver transplantation for hepatocellular carcinoma: Expansion of the tumor size limits does not adversely impact survival. Hepatology 33:1394–1403PubMedGoogle Scholar
  164. 164.
    Roayaie S, Frischer JS, Emre SH, et al. (2002) Long-term results with multimodal adjuvant therapy and liver transplantation for the treatment of hepatocellular carcinoma larger than 5 centimetres. Ann Surg 235:533–539PubMedGoogle Scholar
  165. 165.
    Graziadai IW, Sandmueller H, Waldenberger P, et al. (2003) Chemoembolization followed by liver transplantation for hepatocellular carcinoma impedes tumor progression while on the waiting list and leads to excellent outcomes. Liver Transpl 9:557–563Google Scholar
  166. 166.
    Roayaie S, Frischewr JS, Emre SH, et al. (2002) Long-term results with multimodal adjuvant therapy and liver transplantation for the teatment of hepatocellular carcinoma greater than 5.0 cm. Ann Surg 235:533–539PubMedGoogle Scholar
  167. 167.
    Philosophe B, Greig PP, Hemming AW, et al. (1998) Surgical management of hepatocellular carcinoma: Resection or transplantation? J Gastrointest Surg 2:2–27Google Scholar
  168. 168.
    Chung SW, Toth JL, Rezeig M, et al. (1994) Liver transplantation for hepatocellular carcinoma. Am J Surg 167:317–321PubMedGoogle Scholar
  169. 169.
    Hemming AW, Cattral MS, Reed AI, et al. (2001) Liver transplantation for hepatocellular carcinoma. Ann Surg 233:652–659PubMedGoogle Scholar
  170. 170.
    Saxena R, Ye MQ, Emre S, et al. (1999) Denovo hepatocellular carcinoma in an hepatic allograft with remnant hepatitis C cirrhosis. Liver Transpl Surg 5:81–82PubMedGoogle Scholar
  171. 171.
    Broughan TA, Esquivel CO, Vogt DP, et al. (1994) Pretransplant chemotherapy in pediatric hepatocellular carcinoma. J Pediatr Surg 29:1319–1322PubMedGoogle Scholar
  172. 172.
    Luks FT, St Vil D, Hancock BJ, et al. (1993) Surgical and metabolic aspects of liver transplantation for tyrosinemia. Transplantation 56:1376–1380PubMedGoogle Scholar
  173. 173.
    Tatekawa Y, Asonuma K, Uemoto S, et al. (2001) Liver transplantation for biliary atresia associated with malignant hepatic tumors. J Pediatr Surg 36:436–489PubMedGoogle Scholar
  174. 174.
    Yoo HY, Opatt CH, Geschwind JF, et al. (2003) The outcome of liver transplantation in patients with hepatocellular carcinoma in the United States between 1988–2001: 5-year survival has improved significantly with time. J Clin Oncol 21:4329–4335PubMedGoogle Scholar
  175. 175.
    Yang R, Liu Q, Rescorla FJ, Grosfeld JL (1995) Experimental liver cancer: Improved response after hepatic artery ligation and infusion of tumor necrosis factor alpha, and interferon gamma. Surgery 118:768–774PubMedGoogle Scholar
  176. 176.
    Golladay ES, Mollitt DL, Osteen PK, et al. (1985) Conversion to respectability by intra-arterial infusion chemotherapy after failure of systemic chemotherapy. J Pediatr Surg 20:715–717PubMedGoogle Scholar
  177. 177.
    Yokomari Y, Hari T, Asoh S, et al. (1991) Complete disappearance of unresectable hepatoblastoma by continuous infusion therapy through the hepatic artery. J Pediatr Surg 26:844–846Google Scholar
  178. 178.
    Sue K, Ikeda K, Nakagawara A, et al. (1989) Intrahepatic arterial injections of cisplatin-phosphatidylcholine-Lipiodol suspension in two unresectable hepatoblastoma cases. Med Pediatr Oncol 17:496–500PubMedGoogle Scholar
  179. 179.
    Zhang Z, Liu Q, Ho J, et al. (2000) The effect of preoperative transcatheter hepatic artery chemoembolization on disease free survival after hepatectomy. Cancer 89:2606–2612PubMedGoogle Scholar
  180. 180.
    Llovet JM, Real MI, Montana X, et al. (2002) Arterial embolization or chemoembolization versus symptomatic treatment inpatients with unresectable hepatocellular carcinoma: A randomized controlled trial. Lancet 359:1734–1739PubMedGoogle Scholar
  181. 181.
    Bismuth H, Morino M, Sherlock D, et al. (1992) Primary treatment of hepatocellular carcinoma by arterial embolization. Am J Surg 163:387–394PubMedGoogle Scholar
  182. 182.
    Haider Z, Hag T, Munir K, et al. (2006) Median survival time of patients after transcatheter chemoembolization for hepatocellular carcinoma. J Coll Physicians Surg Pak 16:265–269PubMedGoogle Scholar
  183. 183.
    Hiraoko A, Kumagi T, Hirooka M, et al. (2006) Prognosis following transcatheter arterial embolization for 121 patients with unresectable hepatocellular carcinoma with or without a history of treatment. World J Gastroenterol 12:2075–2079Google Scholar
  184. 184.
    Majno PE, Adam R, Bismuth H, et al. (1997) Influence of preoperative intraarterial Lipiodol chemoembolization on resection and transplantation for hepatocellular carcinoma in patients with cirrhosis. Ann Surg 236:688–701Google Scholar
  185. 185.
    Kitahara S, Makuuchi M, Ishizone S, et al. (1995) Successful left trisegmentectomy for ruptured hepatoblastoma using intra-operative transarterial embolization. J Pediatr Surg 30:1709–1712PubMedGoogle Scholar
  186. 186.
    Berthold F, Schultheis KH, Aigner K, et al. (1986) Combination chemotherapy and chemoembolization in the treatment of primary inoperable hepatoblastoma. Klin Pediatr 198:257–261Google Scholar
  187. 187.
    Uemura S, Todani T, Watanabe Y, et al. (1993) Successful left hepatectomy for hepatocellular carcinoma in a child after transcatheter embolization: Report of a survival. Eur J Pediatr Surg 3:54–56PubMedGoogle Scholar
  188. 188.
    Malogolowkin MH, Stanley P, Steele DA, Ortega JA (2000) Feasibility and toxicity of chemoembolization for children with liver tumors. J Clin Oncol 18:1279–1284PubMedGoogle Scholar
  189. 189.
    Czauderna P, Zbrzezniak G, Narozanski W, et al. (2006) Preliminary experience with arterial chemoembolization for hepatoblastoma/hepatocellular carcinoma in children. Pediatr Blood Cancer 46:825–828PubMedGoogle Scholar
  190. 190.
    Czauderna P, Zbrzezniak G, Narozanski W, et al. (2005) Pulmonary embolism: A fatal complication of arterial chemoembolization for advanced hepatocellular carcinoma. J Pediatr Surg 40:1647–1650PubMedGoogle Scholar
  191. 191.
    Arcement CM, Towbin RB, Gerber DA, et al. (2000) Intrahepatic chemoembolization in unresectable pediatric liver malignancies. Pediatr Radiol 30:779–785PubMedGoogle Scholar
  192. 192.
    Shimamura T, Nakajima Y, Une Y, et al. (1977) Efficacy and safety of preoperative percutaneous transhepatic portal embolization with absolute alcohol: A clinical study. Surgery 121:135–141Google Scholar
  193. 193.
    Abdalla EK, Hicks ME, Vauthey JN (2001) Portal vein embolization: Rationale, technique and future prospects. Br J Surg 88:165–175PubMedGoogle Scholar
  194. 194.
    Madoff DC, Hicks ME, Abdalla EK, et al. (2003) Portal vein embolization with polyvinyl alcohol particles and coils in preparation for major liver resection for hepatic malignancy: Safety and effectiveness—Study in 26 patients. Radiology 227:251–260PubMedGoogle Scholar
  195. 195.
    Farges O, Belghiti J, Kianmanesh R, et al. (2003) Portal vein embolization before right hepatectomy: Prospective clinical trial. Ann Surg 237:208–217PubMedGoogle Scholar
  196. 196.
    Matsumata T, Kanematsu K, Takenaka T, et al. (1989) Lack of intrahepatic recurrence of hepatocellular carcinoma by temporary portal venous embolization with starch microspheres. Surgery 105:188–191PubMedGoogle Scholar
  197. 197.
    Sugiura N, Takara K, Ohto M, et al. (1983) Percutaneous intratumoral injection of ethanol under ultrasound imaging for treatment of small hepatocellular carcinoma. Acta Hepatol Jpn 24:920–923Google Scholar
  198. 198.
    Livraghi T, Festi D, Monti F, et al. (1986) Ultrasound guided percutaneous alcohol injection of small hepatic and abdominal tumors. Radiology 161:309–312PubMedGoogle Scholar
  199. 199.
    Castels A, Bruix J, Bru C, et al. (1993) Treatment of small hepatocellular carcinoma in cirrhotic patients: A cohort study comparing surgical resection and percutaneous ethanol injection. Hepatology 18:1121–1126Google Scholar
  200. 200.
    Chen MS, Li SQ, Zheng V, et al. (2006) A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma. Ann Surg 243:321–328PubMedGoogle Scholar
  201. 201.
    Orlando A, D’Antoni A, Camma C, et al. (2000) Treatment of small hepatocellular carcinoma with percutaneous ethanol injection: A validated prognostic model. Am J Gastroenterol 95:2921–2927PubMedGoogle Scholar
  202. 202.
    Ohnishi K, Yashioka H, Ito S, Fujiwara K (1998) Prospective randomized control trial comparing percutaneous acetic acid and percutaneous ethanol injection for small hepatocellular carcinoma. Hepatology 27:67–72PubMedGoogle Scholar
  203. 203.
    Zhou XD, Tang ZY (1998) Cryotherapy for primary liver cancer. Semin Surg Oncol 14:171–174PubMedGoogle Scholar
  204. 204.
    Chapman WC, Debelak JP, Pinson CW, et al. (2000) Hepatic cryoablation but not radiofrequency ablation results in lung inflammation. Ann Surg 231:752–761PubMedGoogle Scholar
  205. 205.
    Weber SM, Lee FT Jr (2005) Expanded treatment of hepatic tumors with radiofrequency ablation and cryotherapy. Oncology 19:27–32PubMedGoogle Scholar
  206. 206.
    Pawlik TM, Izzo F, Cohen DS, et al. (2003) Combined resection and radiofrequency ablation for advanced hepatic malignancies: Results in 172 patients. Ann Surg Oncol 10:1059–1069PubMedGoogle Scholar
  207. 207.
    Curley SA, Marra P, Beaty K, et al. (2004) Early and late complications after radiofrequency ablation of malignant liver tumors in 608 patients. Ann Surg 239:430–468Google Scholar
  208. 208.
    Curley SA, Izzo F, Ellis LM, et al. (2000) Radiofrequency ablation of hepatocellular cancer in 110 patients with cirrhosis. Ann Surg 232:381–391PubMedGoogle Scholar
  209. 209.
    Bleicher RJ, Allegra DP, Nora DT, et al. (2003) Radiofrequency ablation of 447 complex unresectable liver tumors: Lessons learned. Ann Surg Oncol 10:53–58Google Scholar
  210. 210.
    Livraghi T, Goldberg SN, Lazzaroni S, et al. (1999) Small hepatocellular carcinoma: Treatment with radiofrequency ablation vs. ethanol injection. Radiology 210:655–661PubMedGoogle Scholar
  211. 211.
    Pearson AS, Izzo F, Hemming RY, et al. (1999) Intraoperative radiofrequency ablation or cryoablation for hepatic malignancies. Am J Surg 178:592–599PubMedGoogle Scholar
  212. 212.
    Kim YK, Kim CS, Chung GH, et al. (2006) Radiofrequency ablation of hepatocellular carcinoma with decompensated cirrhosis: Evaluation of therapeutic efficacy and safety. AJR Am J Roentgenol 116(5 Suppl):S 261–268Google Scholar
  213. 213.
    Vettri A, Morreto P, Doriguzzi A, et al. (2006) Radiofrequency ablation after transcatheter chemoembolization for unresectable non-early hepatocellular carcinoma. Eur Radiol 16:661–669Google Scholar
  214. 214.
    Lu DS, Yu NL, Raman CS, et al. (2005) Percutaneous radiofrequency ablation of hepatocellular carcinoma as a bridge to liver transplantation. Hepatology 41:1130–1137PubMedGoogle Scholar
  215. 215.
    Jonas S, Bechstein WO, Heinze T, et al. (1997) Female sex hormone receptor status in advanced hepatocellular carcinoma and outcome after surgical resection. Surgery 121:456–461PubMedGoogle Scholar
  216. 216.
    Boix L, Bruix J, Castells A, et al. (1993) Sex hormone receptors in hepatocellular carcinoma: Is there a rationale for hormonal treatment? J Hepatol 17:187–191PubMedGoogle Scholar
  217. 217.
    Perrone E, Gallo C, Daniele, et al. (2002) Tamoxifen in the treatment of hepatocellular carcinoma: 5-year results of the CLIP-1 multicentre randomized controlled trial. Curr Pharm Des 8:1013–1019PubMedGoogle Scholar
  218. 218.
    Riestra S, Rodriguez M, Delgado M, et al. (1998) Tamoxifen does not improve survival of patients with advanced hepatocellular carcinoma. J Clin Gastroenterol 26:200–203PubMedGoogle Scholar
  219. 219.
    Chow PK, Tai BC, Tan CK, et al. (2002) High-dose tamoxifen in the treatment of inoperable hepatocellular carcinoma: A multi-centre randomized controlled trial. Hepatology 36:1221–1226PubMedGoogle Scholar
  220. 220.
    Schindel DT, Grosfeld JL (1997) Hepatic resection enhances growth of residual intrahepatic and subcutaneous hepatoma which is inhibited by octreotide. J Pediatr Surg 32:995–998PubMedGoogle Scholar
  221. 221.
    Frizelle FA (1995) Octreotide inhibits the growth and development of three types of experimental liver metastases. Br J Surg 82:1577PubMedGoogle Scholar
  222. 222.
    Kouroumalis E, Skordilis P, Thermos K, et al. (1998) Treatment of hepatocellular carcinoma with octreotide: A randomized controlled study. Gut 42:442–447PubMedGoogle Scholar
  223. 223.
    Yuen ME, Poon RT, Lai CL, et al. (2002) A randomized placebo-controlled study of long acting octreotide for the treatment of advanced hepatocellular carcinoma. Hepatology 36:687–691PubMedGoogle Scholar
  224. 224.
    Sun XY, Wu SD, Liao XF, Yuan JY (2005) Tumor angiogenesis and its clinical significance in pediatric malignant liver tumor. World J Gastroenterol 11:741–743PubMedGoogle Scholar
  225. 225.
    Teicher BA, Menon K, Alvarez E, et al. (2001) Antiangiogenic and antitumor effects of a protein kinase C beta inhibitor in human hepatocellular carcinoma and gastric cancer xenografts. In vivo 15:185–193PubMedGoogle Scholar
  226. 226.
    Leung TW, Patt YZ, Lau WY, et al. (1999) Compete pathological remission is possible with systemic combination chemotherapy for inoperable hepatocellular carcinoma. Clin Cancer Res 5:1676–1681PubMedGoogle Scholar
  227. 227.
    Minischetti M, Vacca A, Ribatti D, et al. (2000) TNP-470 and recombinant human interferon-alpha 2a inhibit angiogenesis synergistically. Br J Cancer 109:829–837Google Scholar
  228. 228.
    Patt YZ, Hassan MM, Lozano RD, et al. (2000) Durable clinical response of refractory hepatocellular carcinoma to orally administered thalidomide. Am J Clin Oncol 23:319–321PubMedGoogle Scholar
  229. 229.
    Zeng ZC, Tang ZY, Liu KD, et al. (1998) Improved longterm survival for unresectable hepatocellular carcinoma with a combination of surgery, and intrahepatic arterial infusion of 1311-anti HCC monoclonal antibody. Phase I/II clinical trials. J Cancer Res Clin Oncol 124:275–280PubMedGoogle Scholar
  230. 230.
    Hata Y, Takada N, Sasaki F, et al. (1992) Immunotargeting chemotherapy for alpha fetoprotein producing pediatric liver cancer using conjugates of anti-AFP antibody. J Pediatr Surg 27:724–727PubMedGoogle Scholar
  231. 231.
    Yang R, Liu Q, Rescorla FJ, Grosfeld JL (1995) Experimental liver cancer: Improved response after hepatic artery ligation and infusion of tumor necrosis factor and alpha interferon gamma. Surgery 118:768–774PubMedGoogle Scholar
  232. 232.
    Patt YZ, Hassan MM, Lozano RD, et al. (2003) Phase II trial of systemic continuous fluorouracil and subcutaneous recombinant interferon alpha-2b for treatment of hepatocellular carcinoma. J Clin Oncol 21:421–427PubMedGoogle Scholar
  233. 233.
    Leung TW, Tang AM, Zee B, et al. (2002) Factors predicting response and survival in 149 patients with unresectable hepatocellular carcinoma treated by combination cisplatin, interferon-alpha, doxorubicin, and 5 fluorouracil chemotherapy. Cancer 94:421–427PubMedGoogle Scholar
  234. 234.
    Kubo S, Nishiguchi S, Hirohashi K, et al. (2002) Randomized clinical trial of long-term outcome after resection of hepatitis C virus—Related hepatocellular carcinoma by postoperative interferon therapy. Br J Surg 89:418–422PubMedGoogle Scholar
  235. 235.
    Panis Y, Rad ARK, Boyer O, et al. (1996) Gene therapy for liver tumors. Oncol Clin North Am 5:461–473Google Scholar
  236. 236.
    Kanai F, Shiratori Y, Yoshida Y, et al. (1996) Gene therapy for alpha feto-protein producing human hepatoma cells by adenovirus mediated transfer of herpes simplex virus thymidine-kinase gene. Hepatology 231:1359–1368Google Scholar
  237. 237.
    Sasaki Y, Imaoka S, Masutani S, et al. (1992) Influence of co-existing cirrhosis on long-term prognosis after surgery in patients with hepatocellular carcinoma. Surgery 112:515–521PubMedGoogle Scholar
  238. 238.
    Broderick AL, Jonas MM (2003) Hepatitis B in children. Semin Liver Dis 23:59–68PubMedGoogle Scholar
  239. 239.
    Chang MH, Chen TH, Hsu HM, et al. (2005) Taiwan Hepatocellular Carcinoma Study group—Prevention of hepatocellular carcinoma by universal vaccination against hepatitis B virus: The effect and problems. Clin Cancer Res 11:7953–7957PubMedGoogle Scholar
  240. 240.
    Leung NW (2002) Management of viral hepatitis C. J Gastroenterol Hepatol 17(Suppl 1):S146–S154PubMedGoogle Scholar
  241. 241.
    Ikeda M, Fujiyama S, Tanaka M, et al. (2005) Risk factors for development of hepatocellular carcinoma in patients with chronic hepatitis C after sustained response to interferon. J Gastroenterol 40:220–222Google Scholar
  242. 242.
    Schwimmer JB, Balistreri WF (2000) Transmission, natural history and treatment of hepatitis C virus infection in the pediatric population. Semin Liver Dis 20:37–46PubMedGoogle Scholar
  243. 243.
    Rao GS, Molleston JP (2005) Children with hepatitis C. Curr Gastroenterol Rep 7:37–44PubMedGoogle Scholar
  244. 244.
    Tanaka H, Nouso K, Kobashi H, et al. (2006) Surveillance of hepatocellular carcinoma in patients with hepatitis C virus infection may improve patient survival. Liver Int 26:543–551PubMedGoogle Scholar
  245. 245.
    Lakhdor F, Lawson D, Schatz DA (1994) Fatal parathyroid hormone related protein induced humoral hypercalcemia of malignancy in a three month old infant. Eur J Pediatr 153:718–720Google Scholar
  246. 246.
    Stringer MD, Alizai NK (2005) Mesenchymal hamartomas of the liver: A systemic review. J Pediatr Surg 40:1681–1690PubMedGoogle Scholar
  247. 247.
    Chowdhary SK, Trehan A, Das A, et al. (2004) Undifferentiated embryonal sarcoma in children: Beware of the solitary liver cyst. J Pediatr Surg 39:E9–12PubMedGoogle Scholar
  248. 248.
    Garcia-Bonafe M, Allende H, Fantova MJ, Tarragona J (1997) Fine needle aspiration cytology of undiffrenetiated embryonal sarcoma of the liver. A case report. Acta Cytol 41(4 Suppl):1273–1278PubMedGoogle Scholar
  249. 249.
    deChadarevian JP, Pawel BR, Faerber EN, Weintraub WH (1994) Undifferentiated embryonal sarcoma arising in conjunction with mesenchymal hamartoma of the liver. Mod Pathol 7:490–493Google Scholar
  250. 250.
    Sangkhathat S, Kusafuka T, Nara K, et al. (2006) Non-random p53 mutations in pediatric undifferentiated (embryonal) sarcoma of the liver. Hematol Res 35:229–234Google Scholar
  251. 251.
    Kiani B, Ferrell LD, Qualman S, Frankel WL (2006) Immunohistochemical analysis of embryonal sarcoma of the liver. Appl Immunohistochem Mol Morphol 14:193–197PubMedGoogle Scholar
  252. 252.
    Bisogno G, Pilz T, Perilongo G, et al. (2000) Undifferentiated sarcoma of the liver in childhood: A curable disease. Cancer 94:252–257Google Scholar
  253. 253.
    Dower NA, Smith LJ, Lees G, et al. (2000) Experience with aggressive therapy in three children with unresectable malignant liver tumors. Med Pediatr Oncol 34:132–135PubMedGoogle Scholar
  254. 254.
    Chen JC, Chen CC, Chen W, et al. (1998) Hepatocellular carcinoma in children: Clinical review and comparison with adult cases. J Pediatr Surg 33:1350–1354PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Jay L. Grosfeld
    • 1
  • Jean-Bernard Otte
    • 2
  1. 1.Riley Children’s HospitalIndianapolisUSA
  2. 2.Cliniques Saint-LucBrusselsBelgium

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