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Unkompliziertes Ulcus ventriculi: Pathogenese und konservative Therapie

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Praxis der Viszeralchirurgie

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Zusammenfassung

Magenulzera entstehen durch ein Ungleichgewicht zwischen aggressiven und defensiven Schutzmechanismen im Magen. Ein Großteil der Magenulzera ist durch die Infektion mit H. pylori bedingt und wird durch eine sog. Triple-Therapie behandelt. Zu den aggressiven Faktoren, die die Schleimhaut schädigen, zählt weiterhin die Exposition mit Gallensäuren. Zunehmend häufiger werden NSAR-Gastropathien beobachtet. NSAR schädigen die defensiven Mechanismen der Schleimhaut, vor allem durch die Ausschaltung des COX-1-Isoenzyms, das die Prostaglandinsekretion steuert. Patienten, die unter längerfristiger Medikation mit NSAR Schmerzen entwickeln, sollten mit H2-RA oder PPI prophylaktisch behandelt werden. NSAR-induzierte Läsionen neigen zu Blutungen, die meist endoskopisch gestillt werden können und unter hochdosierter Therapie mit antisekretorischen Medikamenten beschleunigt abheilen.

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Author information

Authors and Affiliations

  1. Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Ismaninger Str. 22, 81675, München

    C. Prinz (Prof. Dr.)

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  1. C. Prinz
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Editors and Affiliations

  1. Medizinische Fakultät der RWTH, Universitätsklinik und Poliklinik, Pauwelsstr. 30, 52057, Aachen

    Volker Schumpelick

  2. Chirurgische Klinik und Poliklinik, Technische Universität München Klinikum rechts der Isar, Ismaninger Str. 22, 81657, München

    Jörg Rüdiger Siewert

  3. Zentrum für Operative Medizin I, Klinikum der Philipps-Universität, Baldinger Straße, 35043, Marburg

    Matthias Rothmund

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© 2006 Springer Medizin Verlag Heidelberg

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Prinz, C. (2006). Unkompliziertes Ulcus ventriculi: Pathogenese und konservative Therapie. In: Schumpelick, V., Siewert, J.R., Rothmund, M. (eds) Praxis der Viszeralchirurgie. Springer, Berlin, Heidelberg . https://doi.org/10.1007/978-3-540-29042-1_40

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  • DOI: https://doi.org/10.1007/978-3-540-29042-1_40

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-29040-7

  • Online ISBN: 978-3-540-29042-1

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