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Biochemical Diagnosis, Staging, and Prediction

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Diseases of the Pancreas

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References

  1. Buchler M, Malfertheiner P, Schoetensack C, Uhl W, Beger HG (1986) Sensitivity of antiproteases, complement factors and C-reactive protein in detecting pancreatic necrosis. Results of a prospective clinical study. Int J Pancreatol 1:227–235

    PubMed  CAS  Google Scholar 

  2. Isenmann R, Rau B, Beger HG (2001) Early severe acute pancreatitis: characteristics of a new subgroup. Pancreas 22:274–278

    Article  PubMed  CAS  Google Scholar 

  3. Johnson CD, Abu-Hilal M (2004) Persistent organ failure during the first week as a marker of fatal outcome in acute pancreatitis. Gut 53:1340–1344

    Article  PubMed  CAS  Google Scholar 

  4. Heinrich S, Schafer M, Rousson V, Clavien PA (2006) Evidence-based treatment of acute pancreatitis: a look at established paradigms. Ann Surg 243:154–168

    Article  PubMed  Google Scholar 

  5. Elman R, Arneson N, Graham EA (1929) Value of blood amylase estimations in the diagnosis of pancreatic disease: a clinical study. Arch Surg 19:943–967

    CAS  Google Scholar 

  6. Trapnell JE (1966) The natural history and prognosis of acute pancreatitis. Ann R Coll Surg Engl 38:265–287

    PubMed  CAS  Google Scholar 

  7. Wilson C, Imrie CW (1988) Deaths from acute pancreatitis: why do we miss the diagnosis so frequently? Int J Pancreatol 3:273–281

    PubMed  CAS  Google Scholar 

  8. Lankisch PG, Schirren CA, Kunze E (1991) Undetected fatal acute pancreatitis: why is the disease so frequently overlooked? Am J Gastroenterol 86:322–326

    PubMed  CAS  Google Scholar 

  9. Saxon EI, Hinkley WC, Vogel WC, Zieve L (1957) Comparative value of serum and urinary amylase in the diagnosis of acute pancreatitis. AMA Arch Intern Med 99:607–621

    PubMed  CAS  Google Scholar 

  10. Thomson HJ, Obekpa PO, Smith AN, Brydon WG (1987) Diagnosis of acute pancreatitis: a proposed sequence of biochemical investigations. Scand J Gastroenterol 22:719–724

    Article  PubMed  CAS  Google Scholar 

  11. Fabris C, Basso D, Naccarato R (1992) Urinary enzymes excretion in pancreatic diseases. Clinical role and pathophysiological considerations. J Clin Gastroenterol 14:281–284

    Article  PubMed  CAS  Google Scholar 

  12. Yadav D, Agarwal N, Pitchumoni CS (2002) A critical evaluation of laboratory tests in acute pancreatitis. Am J Gastroenterol 97:1309–1318

    Article  PubMed  CAS  Google Scholar 

  13. Werner M, Steinberg WM, Pauley C (1989) Strategic use of individual and combined enzyme indicators for acute pancreatitis analyzed by receiver-operator characteristics. Clin Chem 35:967–971

    PubMed  CAS  Google Scholar 

  14. Bradley EL III (1993) A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11–13, 1992. Arch Surg 128:586–590

    PubMed  Google Scholar 

  15. Keim V, Teich N, Fiedler F, Hartig W, Thiele G, Mossner J (1998) A comparison of lipase and amylase in the diagnosis of acute pancreatitis in patients with abdominal pain. Pancreas 16:45–49

    Article  PubMed  CAS  Google Scholar 

  16. Clavien PA, Robert J, Meyer P, Borst F, Hauser H, Herrmann F, Dunand V, Rohner A (1989) Acute pancreatitis and normoamylasemia. Not an uncommon combination. Ann Surg 210:614–620

    Article  PubMed  CAS  Google Scholar 

  17. Spechler SJ, Dalton JW, Robbins AH, Gerzof SG, Stern JS, Johnson WC, Nabseth DC, Schimmel EM (1983) Prevalence of normal serum amylase levels in patients with acute alcoholic pancreatitis. Dig Dis Sci 28:865–869

    Article  PubMed  CAS  Google Scholar 

  18. Ventrucci M, Pezzilli R, Gullo L, Plate L, Sprovieri G, Barbara L (1989) Role of serum pancreatic enzyme assays in diagnosis of pancreatic disease. Dig Dis Sci 34:39–45

    Article  PubMed  CAS  Google Scholar 

  19. Gwozdz GP, Steinberg WM, Werner M, Henry JP, Pauley C (1990) Comparative evaluation of the diagnosis of acute pancreatitis based on serum and urine enzyme assays. Clin Chim Acta 187:243–254

    Article  PubMed  CAS  Google Scholar 

  20. Kitagawa M, Hayakawa T, Kondo T, Shibata T, Sakai Y, Sobajima H, Ishiguro H, Nakae Y (1991) The diagnostic value of serum pancreatic phospholipase A2 (PLA2) in pancreatic diseases. Gastroenterol Jpn 26:62–68

    PubMed  CAS  Google Scholar 

  21. Rau B, Cebulla M, Uhl W, Schoenberg MH, Beger HG (1998) The clinical value of human pancreas-specific protein procarboxypeptidase B as an indicator of necrosis in acute pancreatitis: comparison to CRP and LDH. Pancreas 17:134–139

    Article  PubMed  CAS  Google Scholar 

  22. Tietz NW, Shuey DF (1993) Lipase in serum — the elusive enzyme: an overview. Clin Chem 39:746–756

    PubMed  CAS  Google Scholar 

  23. Toskes PP (1990) Hyperlipidemic pancreatitis. Gastroenterol Clin North Am 19:783–791

    PubMed  CAS  Google Scholar 

  24. Mishkin S, Bates J, O’Hashi J, Schneider P, Sniderman AD, Wolf RO (1976) Possible mechanisms of normal amylase activity in hyperlipemic pancreatitis. Can Med Assoc J 115:1016–1019

    PubMed  CAS  Google Scholar 

  25. Kazmierczak SC, Catrou PG, Van Lente F (1993) Diagnostic accuracy of pancreatic enzymes evaluated by use of multivariate data analysis. Clin Chem 39:1960–1965

    PubMed  CAS  Google Scholar 

  26. Lott JA (1991) The value of clinical laboratory studies in acute pancreatitis. Arch Pathol Lab Med 115:325–326

    PubMed  CAS  Google Scholar 

  27. Warshaw AL, Hawboldt MM (1988) Puzzling persistent hyperamylasemia, probably neither pancreatic nor pathologic. Am J Surg 155:453–456

    Article  PubMed  CAS  Google Scholar 

  28. Gullo L (2000) Familial pancreatic hyperenzymemia. Pancreas 20:158–160

    Article  PubMed  CAS  Google Scholar 

  29. Heikius B, Niemela S, Lehtola J, Karttunen TJ (1999) Elevated pancreatic enzymes in inflammatory bowel disease are associated with extensive disease. Am J Gastroenterol 94:1062–1069

    Article  PubMed  CAS  Google Scholar 

  30. Tietz NW (1997) Support of the diagnosis of pancreatitis by enzyme tests — old problems, new techniques. Clin Chim Acta 257:85–98

    Article  PubMed  CAS  Google Scholar 

  31. Butler J, Bates D (2003) Serum amylase and acute pancreatitis. Emerg Med J 20:550–551

    Article  PubMed  Google Scholar 

  32. Steinberg WM, Goldstein SS, Davis ND, Shamma’a J, Anderson K (1985) Diagnostic assays in acute pancreatitis. A study of sensitivity and specificity. Ann Intern Med 102:576–580

    PubMed  CAS  Google Scholar 

  33. Gumaste VV, Roditis N, Mehta D, Dave PB (1993) Serum lipase levels in nonpancreatic abdominal pain versus acute pancreatitis. Am J Gastroenterol 88:2051–2055

    PubMed  CAS  Google Scholar 

  34. Pieper-Bigelow C, Strocchi A, Levitt MD (1990) Where does serum amylase come from and where does it go? Gastroenterol Clin North Am 19:793–810

    PubMed  CAS  Google Scholar 

  35. Sternby B, O’Brien JF, Zinsmeister AR, DiMagno EP (1996) What is the best biochemical test to diagnose acute pancreatitis? A prospective clinical study. Mayo Clin Proc 71:1138–1144

    PubMed  CAS  Google Scholar 

  36. Kemppainen EA, Hedstrom JI, Puolakkainen PA, Sainio VS, Haapiainen RK, Perhoniemi V, Osman S, Kivilaakso EO, Stenman UH (1997) Rapid measurement of urinary trypsinogen-2 as a screening test for acute pancreatitis. N Engl J Med 336:1788–1793

    Article  PubMed  CAS  Google Scholar 

  37. Kylanpaa-Back ML, Kemppainen E, Puolakkainen P, Hedstrom J, Haapiainen R, Korvuo A, Stenman UH (2002) Comparison of urine trypsinogen-2 test strip with serum lipase in the diagnosis of acute pancreatitis. Hepatogastroenterology; 49:1130–1134

    PubMed  CAS  Google Scholar 

  38. Hedstrom J, Kemppainen E, Andersen J, Jokela H, Puolakkainen P, Stenman UH (2001) A comparison of serum trypsinogen-2 and trypsin-2-alpha1-antitrypsin complex with lipase and amylase in the diagnosis and assessment of severity in the early phase of acute pancreatitis. Am J Gastroenterol 96:424–430

    PubMed  CAS  Google Scholar 

  39. Malfertheiner P, Buchler M, Stanescu A, Uhl W, Ditschuneit H (1987) Serum elastase 1 in inflammatory pancreatic and gastrointestinal diseases and in renal insufficiency. A comparison with other serum pancreatic enzymes. Int J Pancreatol 2:159–170

    PubMed  CAS  Google Scholar 

  40. Millson CE, Charles K, Poon P, Macfie J, Mitchell CJ (1998) A prospective study of serum pancreatic elastase-1 in the diagnosis and assessment of acute pancreatitis. Scand J Gastroenterol 33:664–668

    Article  PubMed  CAS  Google Scholar 

  41. Wilson RB, Warusavitarne J, Crameri DM, Alvaro F, Davies DJ, Merrett N (2005) Serum elastase in the diagnosis of acute pancreatitis: a prospective study. ANZ J Surg 75:152–156

    Article  PubMed  Google Scholar 

  42. Kaiser E (1999) Phospholipase A2: its usefulness in laboratory diagnostics. Crit Rev Clin Lab Sci 36:65–163

    Article  PubMed  CAS  Google Scholar 

  43. Muller CA, Appelros S, Uhl W, Buchler MW, Borgstrom A (2002) Serum levels of procarboxypeptidase B and its activation peptide in patients with acute pancreatitis and non-pancreatic diseases. Gut 51:229–235

    Article  PubMed  CAS  Google Scholar 

  44. Chen CC, Wang SS, Chao Y, Chen SJ, Lee SD, Wu SL, Jeng FS, Lo KJ (1994) Serum pancreas-specific protein in acute pancreatitis. Its clinical utility in comparison with serum amylase. Scand J Gastroenterol 29:87–90

    Article  PubMed  CAS  Google Scholar 

  45. Sarles H (1965) Proposal adopted unanimously by the participants of the symposium on pancreatitis at Marseille, 1963. Bibl Gastroenterol 7:VII–VIII

    Google Scholar 

  46. Ranson JH, Lackner H, Berman IR, Schinella R (1977) The relationship of coagulation factors to clinical complications of acute pancreatitis. Surgery 81:502–511

    PubMed  CAS  Google Scholar 

  47. Imrie CW, Benjamin IS, Ferguson JC, McKay AJ, Mackenzie I, O’Neill J, Blumgart LH (1978) A single-centre doubleblind trial of Trasylol therapy in primary acute pancreatitis. Br J Surg 65:337–341

    Article  PubMed  CAS  Google Scholar 

  48. Brown A, Orav J, Banks PA (2000) Hemoconcentration is an early marker for organ failure and necrotizing pancreatitis. Pancreas 20:367–372

    Article  PubMed  CAS  Google Scholar 

  49. Sun B, Li HL, Gao Y, Xu J, Jiang HC (2003) Factors predisposing to severe acute pancreatitis: evaluation and prevention. World J Gastroenterol 9:1102–1105

    PubMed  Google Scholar 

  50. Gan SI, Romagnuolo J (2004) Admission hematocrit: a simple, useful and early predictor of severe pancreatitis. Dig Dis Sci 49:1946–1952

    Article  PubMed  Google Scholar 

  51. Lankisch PG, Mahlke R, Blum T, Bruns A, Bruns D, Maisonneuve P, Lowenfels AB (2001) Hemoconcentration: an early marker of severe and/or necrotizing pancreatitis? A critical appraisal. Am J Gastroenterol 96:2081–2085

    Article  PubMed  CAS  Google Scholar 

  52. Gudgeon AM, Heath DI, Hurley P, Jehanli A, Patel G, Wilson C, Shenkin A, Austen BM, Imrie CW, Hermon-Taylor J (1990) Trypsinogen activation peptides assay in the early prediction of severity of acute pancreatitis. Lancet 335:4–8

    Article  PubMed  CAS  Google Scholar 

  53. Pezzilli R, Morselli-Labate AM (2001) Hematocrit determination (HCT) as an early marker associated with necrotizing pancreatitis and organ failure. Pancreas 22:433–435

    Article  PubMed  CAS  Google Scholar 

  54. Khan Z, Vlodov J, Horovitz J, Jose RM, Iswara K, Smotkin J, Brown A, Tenner S (2002) Urinary trypsinogen activation peptide is more accurate than hematocrit in determining severity in patients with acute pancreatitis: a prospective study. Am J Gastroenterol 97:1973–1977

    Article  PubMed  CAS  Google Scholar 

  55. Mentula P, Kylanpaa ML, Kemppainen E, Jansson SE, Sarna S, Puolakkainen P, Haapiainen R, Repo H (2005) Early prediction of organ failure by combined markers in patients with acute pancreatitis. Br J Surg 92:68–75

    Article  PubMed  CAS  Google Scholar 

  56. Eachempati SR, Hydo LJ, Barie PS (2002) Severity scoring for prognostication in patients with severe acute pancreatitis: comparative analysis of the Ranson score and the APACHE III score. Arch Surg 137:730–736

    Article  PubMed  Google Scholar 

  57. Talamini G, Bassi C, Falconi M, Sartori N, Frulloni L, Di Francesco V, Vesentini S, Pederzoli P, Cavallini G (1996) Risk of death from acute pancreatitis. Role of early, simple “routine” data. Int J Pancreatol 19:15–24

    PubMed  CAS  Google Scholar 

  58. Halonen KI, Leppaniemi AK, Puolakkainen PA, Lundin JE, Kemppainen EA, Hietaranta AJ, Haapiainen RK (2000) Severe acute pancreatitis: prognostic factors in 270 consecutive patients. Pancreas 21:266–271

    Article  PubMed  CAS  Google Scholar 

  59. Company L, Saez J, Martinez J, Aparicio JR, Laveda R, Grino P, Perez-Mateo M (2003) Factors predicting mortality in severe acute pancreatitis. Pancreatology 3:144–148

    Article  PubMed  CAS  Google Scholar 

  60. Kong L, Santiago N, Han TQ, Zhang SD (2004) Clinical characteristics and prognostic factors of severe acute pancreatitis. World J Gastroenterol 10:3336–3338

    PubMed  Google Scholar 

  61. Halonen KI, Pettila V, Leppaniemi AK, Kemppainen EA, Puolakkainen PA, Haapiainen RK (2002) Multiple organ dysfunction associated with severe acute pancreatitis. Crit Care Med 30:1274–1479

    Article  PubMed  Google Scholar 

  62. Radenkovic D, Bajec D, Karamarkovic A, Stefanovic B, Milic N, Ignjatovic S, Gregoric P, Milicevic M (2004) Disorders of hemostasis during the surgical management of severe necrotizing pancreatitis. Pancreas 29:152–156

    Article  PubMed  Google Scholar 

  63. Heath DI, Meng WC, Anderson JH, Leung KL, Lau WY, Li AK (1997) Failure of the Hong Kong criteria to predict the severity of acute pancreatitis. Int J Pancreatol 22:201–206

    PubMed  CAS  Google Scholar 

  64. Chiari H (1896) Über die Selbstverdauung des menschlichen Pankreas. Zeitschrift für Heilkunde 17:69–96

    Google Scholar 

  65. Frossard JL (2001) Trypsin activation peptide (TAP) in acute pancreatitis: from pathophysiology to clinical usefulness. JOP 2:69–77

    PubMed  CAS  Google Scholar 

  66. Hedstrom J, Sainio V, Kemppainen E, Haapiainen R, Kivilaakso E, Schroder T, Leinonen J, Stenman UH (1996) Serum complex of trypsin 2 and alpha 1 antitrypsin as diagnostic and prognostic marker of acute pancreatitis: clinical study in consecutive patients. BMJ 313:333–337

    PubMed  CAS  Google Scholar 

  67. Wilson C, Heads A, Shenkin A, Imrie CW (1989) C-reactive protein, antiproteases and complement factors as objective markers of severity in acute pancreatitis. Br J Surg 76:177–181

    Article  PubMed  CAS  Google Scholar 

  68. Dominguez-Munoz JE, Carballo F, Garcia MJ, Miguel de Diego J, Gea F, Yanguela J, de la Morena J (1993) Monitoring of serum proteinase-antiproteinase balance and systemic inflammatory response in prognostic evaluation of acute pancreatitis. Results of a prospective multicenter study. Dig Dis Sci 38:507–513

    Article  PubMed  CAS  Google Scholar 

  69. Borgstrom A, Appelros S, Muller CA, Uhl W, Buchler MW (2002) Role of activation peptides from pancreatic proenzymes in the diagnosis and prognosis of acute pancreatitis. Surgery 131:125–128

    Article  PubMed  Google Scholar 

  70. Tenner S, Fernandez-del Castillo C, Warshaw A, Steinberg W, Hermon-Taylor J, Valenzuela JE, Hariri M, Hughes M, Banks PA (1997) Urinary trypsinogen activation peptide (TAP) predicts severity in patients with acute pancreatitis. Int J Pancreatol 21:105–110

    PubMed  CAS  Google Scholar 

  71. Neoptolemos JP, Kemppainen EA, Mayer JM, Fitzpatrick JM, Raraty MG, Slavin J, Beger HG, Hietaranta AJ, Puolakkainen PA (2000) Early prediction of severity in acute pancreatitis by urinary trypsinogen activation peptide: a multicentre study. Lancet 355:1955–1960

    Article  PubMed  CAS  Google Scholar 

  72. Johnson CD, Lempinen M, Imrie CW, Puolakkainen P, Kemppainen E, Carter R, McKay C (2004) Urinary trypsinogen activation peptide as a marker of severe acute pancreatitis. Br J Surg 91:1027–1033

    Article  PubMed  CAS  Google Scholar 

  73. Kemppainen E, Mayer J, Puolakkainen P, Raraty M, Slavin J, Neoptolemos JP (2001) Plasma trypsinogen activation peptide in patients with acute pancreatitis. Br J Surg 88:679–680

    Article  PubMed  CAS  Google Scholar 

  74. Pezzilli R, Morselli-Labate AM, Barbieri AR, Plate L (2000) Clinical usefulness of the serum carboxypeptidase B activation peptide in acute pancreatitis. JOP 1:58–68

    PubMed  CAS  Google Scholar 

  75. Appelros S, Petersson U, Toh S, Johnson C, Borgstrom A (2001) Activation peptide of carboxypeptidase B and anionic trypsinogen as early predictors of the severity of acute pancreatitis. Br J Surg 88:216–221

    Article  PubMed  CAS  Google Scholar 

  76. Saez J, Martinez J, Trigo C, Sanchez-Paya J, Grino P, Company L, Laveda R, Penalva JC, Garcia C, Perez-Mateo M (2004) A comparative study of the activation peptide of carboxypeptidase B and trypsinogen as early predictors of the severity of acute pancreatitis. Pancreas 29:e9–14

    Article  PubMed  CAS  Google Scholar 

  77. Gurleyik G, Cirpici OZ, Aktekin A, Saglam A (2004) [The value of Ranson and APACHE II scoring systems, and serum levels of interleukin-6 and C-reactive protein in the early diagnosis of the severity of acute pancreatit is]. Ulus Travma Derg 10:83–88

    Google Scholar 

  78. Puolakkainen P, Valtonen V, Paananen A, Schroder T (1987) C-reactive protein (CRP) and serum phospholipase A2 in the assessment of the severity of acute pancreatitis. Gut 28:764–771

    Article  PubMed  CAS  Google Scholar 

  79. Rau B, Steinbach G, Baumgart K, Gansauge F, Grunert A, Beger HG (2000) Serum amyloid A versus C-reactive protein in acute pancreatitis: clinical value of an alternative acutephase reactant. Crit Care Med 28:736–742

    Article  PubMed  CAS  Google Scholar 

  80. Rau B, Schilling MK, Beger HG (2004) Laboratory markers of severe acute pancreatitis. Dig Dis 22:247–257

    Article  PubMed  CAS  Google Scholar 

  81. Rau B, Steinbach G, Gansauge F, Mayer JM, Grunert A, Beger HG (1997) The potential role of procalcitonin and interleukin 8 in the prediction of infected necrosis in acute pancreatitis. Gut 41:832–840

    Article  PubMed  CAS  Google Scholar 

  82. Mayer JM, Raraty M, Slavin J, Kemppainen E, Fitzpatrick J, Hietaranta A, Puolakkainen P, Beger HG, Neoptolemos JP (2002) Serum amyloid A is a better early predictor of severity than C-reactive protein in acute pancreatitis. Br J Surg 89:163–171

    PubMed  CAS  Google Scholar 

  83. Rau BM, Kruger CM, Schilling MK (2005) Anti-cytokine strategies in acute pancreatitis: pathophysiological insights and clinical implications. Rocz Akad Med Bialymst 50:106–115

    PubMed  CAS  Google Scholar 

  84. Heath DI, Cruickshank A, Gudgeon M, Jehanli A, Shenkin A, Imrie CW (1993) Role of interleukin-6 in mediating the acute phase protein response and potential as an early means of severity assessment in acute pancreatitis. Gut 34:41–45

    Article  PubMed  CAS  Google Scholar 

  85. Brivet FG, Emilie D, Galanaud P (1999) Pro-and anti-inflammatory cytokines during acute severe pancreatitis: an early and sustained response, although unpredictable of death. Parisian Study Group on Acute Pancreatitis. Crit Care Med 27:749–755

    Article  PubMed  CAS  Google Scholar 

  86. Chen CC, Wang SS, Lee FY, Chang FY, Lee SD (1999) Proinflammatory cytokines in early assessment of the prognosis of acute pancreatitis. Am J Gastroenterol 94:213–218

    Article  PubMed  CAS  Google Scholar 

  87. Mayer J, Rau B, Gansauge F, Beger HG (2000) Inflammatory mediators in human acute pancreatitis: clinical and pathophysiological implications. Gut 47:546–552

    Article  PubMed  CAS  Google Scholar 

  88. Dugernier TL, Laterre PF, Wittebole X, Roeseler J, Latinne D, Reynaert MS, Pugin J (2003) Compartmentalization of the inflammatory response during acute pancreatitis: correlation with local and systemic complications. Am J Respir Crit Care Med 168:148–157

    Article  PubMed  Google Scholar 

  89. Stimac D, Fisic E, Milic S, Bilic-Zulle L, Peric R (2006) Prognostic values of IL-6, IL-8, and IL-10 in acute pancreatitis. J Clin Gastroenterol 40:209–212

    Article  PubMed  CAS  Google Scholar 

  90. Gross V, Andreesen R, Leser HG, Ceska M, Liehl E, Lausen M, Farthmann EH, Scholmerich J (1992) Interleukin-8 and neutrophil activation in acute pancreatitis. Eur J Clin Invest 22:200–203

    Article  PubMed  CAS  Google Scholar 

  91. Pezzilli R, Billi P, Miniero R, Fiocchi M, Cappelletti O, Morselli-Labate AM, Barakat B, Sprovieri G, Miglioli M (1995) Serum interleukin-6, interleukin-8, and beta 2-microglobulin in early assessment of severity of acute pancreatitis. Comparison with serum C-reactive protein. Dig Dis Sci 40:2341–2348

    Article  PubMed  CAS  Google Scholar 

  92. Gross V, Scholmerich J, Leser HG, Salm R, Lausen M, Ruckauer K, Schoffel U, Lay L, Heinisch A, Farthmann EH, Gerok W (1990) Granulocyte elastase in assessment of severity of acute pancreatitis. Comparison with acute-phase proteins Creactive protein, alpha 1-antitrypsin, and protease inhibitor alpha 2-macroglobulin. Dig Dis Sci 35:97–105

    Article  PubMed  CAS  Google Scholar 

  93. Dominguez-Munoz JE, Carballo F, Garcia MJ, de Diego JM, Rabago L, Simon MA, de la Morena J (1991) Clinical usefulness of polymorphonuclear elastase in predicting the severity of acute pancreatitis: results of a multicentre study. Br J Surg 78:1230–1234

    Article  PubMed  CAS  Google Scholar 

  94. Uhl W, Buchler M, Malfertheiner P, Martini M, Beger HG (1991) PMN-elastase in comparison with CRP, antiproteases, and LDH as indicators of necrosis in human acute pancreatitis. Pancreas 6:253–259

    Article  PubMed  CAS  Google Scholar 

  95. Viedma JA, Perez-Mateo M, Agullo J, Dominguez JE, Carballo F (1994) Inflammatory response in the early prediction of severity in human acute pancreatitis. Gut 35:822–827

    Article  PubMed  CAS  Google Scholar 

  96. Dominguez-Munoz JE, Villanueva A, Larino J, Mora T, Barreiro M, Iglesias-Canle J, Iglesias-Garcia J (2006) Accuracy of plasma levels of polymorphonuclear elastase as early prognostic marker of acute pancreatitis in routine clinical conditions. Eur J Gastroenterol Hepatol 18:79–83

    Article  PubMed  Google Scholar 

  97. Nevalainen TJ, Hietaranta AJ, Gronroos JM (1999) Phospholipase A2 in acute pancreatitis: new biochemical and pathological aspects. Hepatogastroenterology 46:2731–2735

    PubMed  CAS  Google Scholar 

  98. Nevalainen TJ, Gronroos JM, Kortesuo PT (1993) Pancreatic and synovial type phospholipases A2 in serum samples from patients with severe acute pancreatitis. Gut 34:1133–1136

    Article  PubMed  CAS  Google Scholar 

  99. Bird NC, Goodman AJ, Johnson AG (1989) Serum phospholipase A2 activity in acute pancreatitis: an early guide to severity. Br J Surg 76:731–732

    Article  PubMed  CAS  Google Scholar 

  100. Mayer J, Rau B, Grewe M, Schoenberg MH, Nevalainen TJ, Beger HG (1998) Secretory phospholipase A2 in patients with infected pancreatic necroses in acute pancreatitis. Pancreas 17:272–277

    Article  PubMed  CAS  Google Scholar 

  101. Assicot M, Gendrel D, Carsin H, Raymond J, Guilbaud J, Bohuon C (1993) High serum procalcitonin concentrations in patients with sepsis and infection. Lancet 341:515–518

    Article  PubMed  CAS  Google Scholar 

  102. Simon L, Gauvin F, Amre DK, Saint-Louis P, Lacroix J (2004) Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis. Clin Infect Dis 39:206–217

    Article  PubMed  CAS  Google Scholar 

  103. Uhl W, Warshaw A, Imrie C, Bassi C, McKay CJ, Lankisch PG, Carter R, Di Magno E, Banks PA, Whitcomb DC, Dervenis C, Ulrich CD, Satake K, Ghaneh P, Hartwig W, Werner J, McEntee G, Neoptolemos JP, Buchler MW (2002) IAP Guidelines for the Surgical Management of Acute Pancreatitis. Pancreatology 2:565–573

    Article  PubMed  Google Scholar 

  104. Working Party of the British Society of Gastroenterology; Association of Surgeons of Great Britain and Ireland; Pancreatic Society of Great Britain and Ireland; Association of Upper GI Surgeons of Great Britain and Ireland (2005) UK guidelines for the management of acute pancreatitis. Gut 54Suppl 3:iii1–9

    Article  Google Scholar 

  105. Rau B, Kruger CM, Schilling MK (2004) Procalcitonin: improved biochemical severity stratification and postoperative monitoring in severe abdominal inflammation and sepsis. Langenbecks Arch Surg 389:134–144

    Article  PubMed  CAS  Google Scholar 

  106. Kylanpaa-Back ML, Takala A, Kemppainen EA, Puolakkainen PA, Leppaniemi AK, Karonen SL, Orpana A, Haapiainen RK, Repo H (2001) Procalcitonin, soluble interleukin-2 receptor, and soluble E-selectin in predicting the severity of acute pancreatitis. Crit Care Med 29:63–69

    Article  PubMed  CAS  Google Scholar 

  107. Kylanpaa-Back ML, Takala A, Kemppainen E, Puolakkainen P, Haapiainen R, Repo H (2001) Procalcitonin strip test in the early detection of severe acute pancreatitis. Br J Surg 88:222–227

    Article  PubMed  CAS  Google Scholar 

  108. Rau B, Kemppainen E, Gumb A, Büchler MW, Wegscheider K, Bassi C, Puolakkainen P, Beger HG (2007) Early assessment of pancreatic infections and overall prognosis in severe acute pancreatitis by procalcitonin (PCT): a prospective international multicenter study. Ann Surg 245:745–754

    Article  PubMed  Google Scholar 

  109. Purkayastha S, Chow A, Athanasiou T, Cambaroudis A, Panesar S, Kinross J, Tekkis P, Darzi A (2006) Does serum procalcitonin have a role in evaluating the severity of acute pancreatitis? A question revisited. World J Surg 30:1713–1721

    Article  PubMed  Google Scholar 

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Rau, B.M. (2008). Biochemical Diagnosis, Staging, and Prediction. In: Beger, H.G., Matsuno, S., Cameron, J.L., Rau, B.M., Sunamura, M., Schulick, R.D. (eds) Diseases of the Pancreas. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-28656-1_19

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