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Heart

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Clinical Nuclear Medicine

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Abstract

Myocardial perfusion imaging has evolved over 30 years to the point where it can now provide diagnostic and prognostic information in nearly all patient groups. Early studies were performed with K-43 in animal models and in man, but it was only with the availability of thallium-201 (Tl-201) in the mid 1970s that the technique using planar imaging became widely utilized for detecting the presence and extent of coronary artery disease (CAD). In the mid 1980s SPECT was introduced and became the predominant method of acquisition. All the early studies were performed using exercise stress. Since not all patients are capable of exercising, the introduction of dipyridamole, adenosine and dobutamine for pharmacologic stress in the 1980s and 1990s allowed perfusion studies to be performed in nearly all patients. Tl-201 is not the ideal perfusion tracer and in the late 1980s the technetium-99m (Tc99m) labeled perfusion tracer, sestamibi, became available followed in the mid 1990s by Tc-99m tetrofosmin. These two tracers now account for the majority of perfusion studies.

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Authors and Affiliations

  1. Department of Molecular and Functional Imaging, Cleveland Clinic Foundation, 9500 Euclid Ave., GB-3, Cleveland, OH, 44195, USA

    M. D. Cerqueira MD

  2. Coimbra University Hospital Coimbra University School of Medicine, Coimbra, Portugal

    M. J. Vidigal Ferreira MD

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  1. M. D. Cerqueira MD
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Editors and Affiliations

  1. Department of Nuclear Medicine, University Hospital Bonn, Sigmund-Freud-Straße 15, D-53127, Bonn, Germany

    Hans-Jürgen Biersack M.D. (Professor and Chairman) (Professor and Chairman)

  2. Nuclear Medicine and Radiology, Albert Einstein College of Medicine Director, Dept. of Nuclear Medicine Montefiore Medical Centre/Moses Division, 111 East 210th Street, Bronx, NY, 10467, USA

    Leonard M. Freeman M.D. (Professor) (Professor)

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Cerqueira, M.D., Ferreira, M.J.V. (2007). Heart. In: Biersack, HJ., Freeman, L.M. (eds) Clinical Nuclear Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-28026-2_4

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