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IMGT-Choreography: Processing of Complex Immunogenetics Knowledge

  • Denys Chaume
  • Véronique Giudicelli
  • Kora Combres
  • Chantal Ginestoux
  • Marie-Paule Lefranc
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 3082)

Abstract

IMGT, the international ImMunoGeneTics information system® (http://imgt.cines.fr) is a high quality integrated knowledge resource specialized in immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrates. IMGT provides a common access to standardized data from genome, proteome, genetics and tridimensional structures. The accuracy and the consistency of IMGT data are based on IMGT-ONTOLOGY, a semantic specification of terms used in immunogenetics and immunoinformatics. IMGTONTOLOGY is formalized using XML schemas (IMGT-ML) for interoperability with other information systems. We are developing Web services to automatically query IMGT databases and tools. This is the first step towards IMGT-Choreography which will trigger and coordinate dynamic interactions between IMGT Web services, to process complex significant biological and clinical requests. IMGT-Choreography will further increase the IMGT leadership in immunogenetics medical research (repertoire analysis in autoimmune diseases, AIDS, leukemias,...), biotechnology related to antibody engineering and therapeutical approaches.

Keywords

Major Histocompatibility Complex Genome Analysis Tool International ImMunoGeneTics International ImMunoGeneTics Information System IMGT Unique Numbering 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Denys Chaume
    • 1
  • Véronique Giudicelli
    • 1
  • Kora Combres
    • 1
  • Chantal Ginestoux
    • 1
  • Marie-Paule Lefranc
    • 1
    • 2
  1. 1.Laboratoire d’ImmunoGénétique Moléculaire LIGMUniversité Montpellier II, UPR CNRS 1142, Institut de Génétique Humaine IGHMontpellierFrance
  2. 2.Institut Universitaire de FranceParisFrance

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