Building and Analysing an Integrative Model of HIV-1 RNA Alternative Splicing

  • A. Bockmayr
  • A. Courtois
  • D. Eveillard
  • M. Vezain
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 3082)


We present a multi-site model describing the alternative use of the RNA splicing sites A3, A4, A5 and A7 in the human immunodeficiency virus HIV-1. Our goal is to integrate experimental data obtained on individual splicing sites into a global model of HIV-1 RNA alternative splicing. We give a qualitative validation of our model, and analyse the possible impact of variations of regulatory protein concentrations on virus multiplication.


Splice Site Acceptor Site Virus Life Cycle Splice Regulation Hybrid Automaton 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • A. Bockmayr
    • 1
  • A. Courtois
    • 1
  • D. Eveillard
    • 1
    • 2
  • M. Vezain
    • 1
  1. 1.LORIA, UMR 7503 (CNRS, INRIA, Universités de Nancy)Vandœuvre-lès-NancyFrance
  2. 2.Laboratoire de Maturation des ARN et Enzymologie Moléculaire, UMR 7567 CNRS-UHPVandoeuvre-lès-NancyFrance

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