Abstract
Magainin-2 is a natural peptide that kills bacteria at concentrations that are harmless to animal cells. Molecular modelling methods were applied to investigate basic mechanisms of magainin-2 amide (M2a) membrane selectivity. Three computer models of a lipid matrix of either animal or bacterial membrane containing M2a were constructed and simulated. Specific interactions between membrane lipids and M2a peptides, responsible for M2a selectivity are elucidated.
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Murzyn, K., Róg, T., Pasenkiewicz-Gierula, M. (2004). Interactions of Magainin-2 Amide with Membrane Lipids. In: Bubak, M., van Albada, G.D., Sloot, P.M.A., Dongarra, J. (eds) Computational Science - ICCS 2004. ICCS 2004. Lecture Notes in Computer Science, vol 3037. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-24687-9_41
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DOI: https://doi.org/10.1007/978-3-540-24687-9_41
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