Skip to main content
SpringerLink
Log in

Parathormone, Calcium Imbalance and Atherogenesis

  • Chapter
New Aspects of Metabolism and Behaviour of Mesenchymal Cells during the Pathogenesis of Arteriosclerosis

Part of the book series: Abhandlungen der Rheinisch-Westfälischen Akademie der Wissenschaften ((ARAW,volume 87))

  • 53 Accesses

Abstract

Arteriosclerosis is very strongly connected with the aging process. The lots of theories over the last 170 years elucidate two crucial problems of arteriosclerosis research:

  1. 1.

    Arteriosclerosis (AS) is generated by multiple endogenous and exogenous factors influencing differently the progression of the disease.

  2. 2.

    Arteriosclerosis develops very slowly over decades. That means the causing biochemical agents may show only minimal deviations from normal range at any given time of the pathogenesis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Assmann, G., Oberwittler, W., Schulte, H., Schriewer, H., Funke, H., Epping, P.H., Hauss, W.H.: Prädiktion und Früherkennung der koronaren Herzkrankheit — Prospektive epidemiologische Studie bei Betriebsangehörigen im Raum Westfalen. Internist. 1980; 21: 446–459.

    PubMed  CAS  Google Scholar 

  2. Assmann, G.: Lipid metabolism and atherosclerosis. Schattauer Stuttgart, New York 1982.

    Google Scholar 

  3. Assmann, G., Schulte, H.: Prediction and early detection of coronary heart disease. Rhein: Westfäl. Akad. der Wissenschaften. Abhandlung Bd. 70, Westdeutscher Verlag 1983.

    Google Scholar 

  4. Bagdade, J.D.: Hyperlipidemia and atherosclerosis in chronic dialysis patients. In: Drukker, W. et al. (Ed.): Replacement of renal function by dialysis. Martinus Nijhoff Publ. Bosten, Den Haag 1983; II. Edition: 588–594.

    Chapter  Google Scholar 

  5. Borle, A.B.: Calcium metabolism in hela cells and the effects of parathyreoid hormone. Journal Cell. Biol. 1968; 36: 567–582.

    Article  CAS  Google Scholar 

  6. Brunner, F.P., Brynger, H., Chantier, C., Donckerwolcke, RA., Hathway, R.A., Jacobs, C., Selwood, N.H., Wing, A.J.: Combined report on regular dialysis and transplantation in Europe IX, 1978: Proc. EDTA 1979; 16: 2–70.

    Google Scholar 

  7. Cavaliero, C., Di Tondo, U., Mingazzini, P., Pesando, P., Spagnoli, L.: Cell proliferation in the atherosclerotic lesions of cholesterol-fed rabbits. Atherosclerosis 1973; 17: 49–62.

    Article  Google Scholar 

  8. Cheung, J.Y., Bonventre, J.V., Malis, C.D., Leaf, A.: Calcium and ischemic injury. N. Engl. J. Med. 1986; 314: 1670–1676.

    Article  PubMed  CAS  Google Scholar 

  9. with highly potent inhibitory effects on excitation-contractation coupling in mammalian myocardium. Pflügers Arch. Ges. Physiol. 1969; 307: 25.

    Google Scholar 

  10. Fleckenstein, A.: Calcium antagonism: history and prospects for a multifacted pharmacodynamic principle. In: Calcium antagonists and cardiovascular Disease; Opie LH (Ed.), Raven Press. New York 1984; 9–28.

    Google Scholar 

  11. Fleckenstein, A., Frey, M., Zorn, J., Fleckenstein-Grün, G.: Antihypertensive anticalcitonische und antiarteriosklerotische Effekte von Calcium-Antagonisten. Modell-Experimente an spontan-hypertensiven Ratten (SHR). In: Distler A. (Ed.): Calcium-Antagonisten in der Hochdrucktherapie. Schattauer-Verlag Stuttgart, New York 1986; 3–24.

    Google Scholar 

  12. Goldberg, A.P., Harter, H.R., Patsch, W., Schechtman, K.B., Province, M., Weerts, C., Kuisk, I., McCrate, M.: Racial differences in plasma high density lipoproteins in patients receiving hemodialysis. N. Engl. J. Med. 1983; 308: 1245–1252.

    Article  PubMed  CAS  Google Scholar 

  13. Green, D., Stone, N.J., Krumlovsky, F.A.: Putative atherogenic factors in patients with chronic renal failure. Prog. Cardiovasc. Dis. 1983; 26: 133–144.

    Article  PubMed  CAS  Google Scholar 

  14. Grützmacher, P., Radtke, H.W., Schieferdecker, E., Peschke, B., Riepenhausen, J., Fassbinder, W., Schoeppe, W.: Early changes of plasma lipid status and glucose tolerance during the course of chronical renal failure. Contr. Nephrol. 1984; 41: 332–336.

    Google Scholar 

  15. Grützmacher, P.: Is hyperparathyroidism a risk factor for atherosclerosic disease in RDT patients. Nephrol. Dial. Transplant. 1986; 1: 122–123.

    Google Scholar 

  16. Hahn, R., Oette, K., Mondorf, H., Finke, K., Sieberth, H.G.: Analysis of cardiovascular risk factors in chronic hemodialysis patients with special attention to the hyperlipoproteinamias. Atherosclerosis 1983; 48: 279–288.

    Article  PubMed  CAS  Google Scholar 

  17. Hauss, W.H.: Ober Entstehung und Verhütung der Arteriosklerose. Arbeitsgemeinschaft fir Forschung des Landes NRW, Heft N 197: 7–33. Westdeutscher Verlag Köln-Opladen 1970.

    Google Scholar 

  18. Hehrmann, R.: Plasma-Parathormon: Methodik, Pathphysiologie und Klinik. Urban & Schwarzenberg Verlag München—Wien 1980.

    Google Scholar 

  19. Henry, P.D.: Atherosclerosis, calcium and calcium antagonists. Circulation 1985; 72: 456–569.

    Article  PubMed  CAS  Google Scholar 

  20. Henry, P.D., Bentley, K.I.: Suppression of atherogenesis in cholesterol-fed rabbit treated with nifedipine. J. Clin. Invest. 1981; 68: 1366–1369.

    Article  PubMed  CAS  Google Scholar 

  21. Hirata, Y., Yoshimi, H., Takata, S., Watanabe, T.X., Kumegai, S., Nakajima, K., Sakakibara, S.: Cellular mechanism of action by a novel vasoconstrictor endothelin in cultured rat vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 1988; 154: 868–875.

    Article  PubMed  CAS  Google Scholar 

  22. Horsch, A., Ritz, E., Heuck, C.C., Hofmann, W., Kühne, E., Bisson, M.: Atherogenesis in experimental uremia. Atherosis 1981; 40: 279–289.

    Article  CAS  Google Scholar 

  23. Kai, H., Kanaide, H., Nakamura, M.: Endothelin-sensitive intracellular Ca store overlaps with caffeine-sensitive one in rat aortic smooth muscle cells in primary culture. Biochem. Biophys. Res. Commun. 1989; 158: 235–243.

    Article  PubMed  CAS  Google Scholar 

  24. Karpf, D.B., Bambino, T., Arnaud, D.C., Nissenson, R.A.: Molecular determinants of parathyroid hormone receptor function. In: Cohn, D.V., Charieur, F.H., Martin, T.J. (Ed.): Calcium regulation and bone metabolism, Elsevier Science Publishers 1990.

    Google Scholar 

  25. Krall, E.A., Sahyoun, N., Tannenbaum, S., Dallai, G.E., Dawson-Hughes, B.: Effect of vitamin D intake on seasonal variations in parathyreiod hormone secretion in postmenopausal women. N. Engl. J. Med. 1989; 321: 1777–1783.

    Article  PubMed  CAS  Google Scholar 

  26. Kramsch, D.M., Aspen, A.J., Apstein, C.S.: Suppression of experimental atherosclerosis by the Ca-Antagonist Lanthanum. J. Clin. Invest. 1980; 65: 976–981.

    Article  Google Scholar 

  27. Lichtlen, P.R., Hugenholtz, P.G., Raffenbeul, W., Hecker, H., Jost, S., Deckers, J.W.: Retardation of angiographic progression of coronary artery disease by nifedipine. Lancet 1990; 335: 1109–1113.

    Article  PubMed  CAS  Google Scholar 

  28. Lindner, A., Haas, L., Sherrard, DJ.: Atherosclerosis in uremia. “The seattle experience re-visited”. Panel conference Trans. ASAIO 1981; XXVII: 669–670.

    Google Scholar 

  29. Mordasini, R.: Sekundäre Hyperlipoproteinämien bei chronischen Nierenkrankheiten. Verlag Hans Huber Bern—Stuttgart—Wien 1982.

    Google Scholar 

  30. Morrisson, L.M., Bajwa, G.S., Alfin-Slater, R.B., Ershoff, B.H.: Prevention of vascular lesions by chondroitin sulfate a in the coronary artery and aorta of rats induced by a hypervitaminosis D, cholesterol-containing diet. Atherosclerosis 1972; 16: 105–118.

    Article  Google Scholar 

  31. Müller, O.A., van Werder, K.: Rezeptorstörungen in der Endokrinologie- Internist. 1988; 29: 445–454.

    Google Scholar 

  32. Mundy, G.R.: Calcium homeostasis: hypercalcemia and hypocalcemia. Martin Dunitz, London 1989; 149.

    Google Scholar 

  33. Nestel, P.J., Fidge, N.H., Tan M.H.: Increased lipoprotein-remnant formation in chronic renal failure. N. Engl. J. Med. 1982; 307: 329–333.

    Article  PubMed  CAS  Google Scholar 

  34. Oster, P., Müller, T., Schmidt-Gayk, H., Schlierf, G.: Parathyreoid hormone, 25-hyroxyvitamin D and 1,25dihydroxy-vitamin D concentration in elderly patients. Kiin. Wochenschr. 1990; 68: 421–426.

    Article  CAS  Google Scholar 

  35. Parrot-Garcia, M., McCarron, D.A.: Calcium and hypertension. Nutrition Rev. 1984; 42: 205–213.

    Article  Google Scholar 

  36. Petersen, M.M., Briggs, R.S., Ashby, M.A., Reid, R.I., Hall, M.R., Wood, P.J., Clayton, B.E.: Parathyreoid hormone and 25-hydrxyvitamin D concentrations in sick and normal elderly people. Brit. Med. J. 1983; 287: 521–523.

    Article  CAS  Google Scholar 

  37. Raidt, H.: Untersuchungen zur Atherogenese bei dialysepflichtiger Niereninsuffizienz. Habilitationsschrift; Universität Münster 1987.

    Google Scholar 

  38. Raidt, H., Langer, K., Baumgarten, F. et al.: Hyperparathyreoidism and accelerated arteriosclerosis in uraemic patients. Nephrol. Dial. Transplant. 1987; 2: 418.

    Google Scholar 

  39. Raisz, L.G., Kream, B.E.: Regulation of bone formation. N. Engl. J. Med. 1983; 1: 29–35.

    Article  Google Scholar 

  40. Rambausek, M., Ritz, E., Rascher, W., Kreusser, W., Mann, J.F.E., Kreye, V.A.W., Mehls, O.: Vascular effects of paratyreiod hormone. Adv. Exp. Med. Biol. 1982; 151: 619–632.

    Article  PubMed  CAS  Google Scholar 

  41. Rapoport, J., Aviram, M., Chaimovitz, C., Brook, J.G.: Defective high-density lipoprotein composition in patients on chronic hemodialysis. N. Engl. J. Med. 1978; 299: 1326–1329.

    Article  PubMed  CAS  Google Scholar 

  42. Rasmussen, H.: The calcium messenger system. First part. N. Engl. J. Med. 1986; 314: 1094–1101.

    Article  PubMed  CAS  Google Scholar 

  43. Rasmussen, H.: The calcium messenger system Second Part. N. Engl. J. Med. 1986; 314: 1164–1170.

    Article  PubMed  CAS  Google Scholar 

  44. Reichel, H., Koeffler, H.P., Norman, A.W.: The role of the vitamin D endocrine system in health and disease. N. Engl. J. Med. 1989; 320: 980–991.

    Article  PubMed  CAS  Google Scholar 

  45. Ritz, E., Augustin, J., Bommer, J., Gnasso, A., Haberbosch, W.: Should hyperlipidemia of renal failure be treated? Kidney Int. 1985; 28, Suppl.: 84–87.

    Google Scholar 

  46. Ross, R.: The pathogenesis of atherosclerosis an update. N. Engl. J. Med. 1986; 314: 488–500.

    Article  PubMed  CAS  Google Scholar 

  47. Rostand, S.G., Kirk, K.A., Rutsky, E.A.: Dialysis-associated ischemic heart disease: Insights from coronary angiography. Kidney Int. 1984; 25: 653–659.

    Article  PubMed  CAS  Google Scholar 

  48. Rüegg, J.C.: Calcium in muscle activation. Springer-Verlag Berlin, Heidelberg, New York 1986.

    Google Scholar 

  49. Slatopolsky, E., Martin, K., Hruska, K.: Parathyreoid hormone metabolism and its potential role as a uremic toxin. Am. J. Physiol. 1980; 239: 1–11.

    Google Scholar 

  50. Snyder, S.H., Reynolds, IJ.: Calcium-antagonist drugs: Receptor-interactions that clarify therapeutic effects. N. Engl. J. Med. 1985; 313: 995–1002.

    Article  PubMed  CAS  Google Scholar 

  51. Sokoll, L.J., Morrow, F.D., Quirbach, D.M., Dawson-Hughes, B.: Intact parathyrin in postmenopausal women. Clin. Chem. 1988; 34: 407–410.

    PubMed  CAS  Google Scholar 

  52. Sugiura, M., Inagami, T., Hare, G.M.T., Johns, J.A.: Endothelin action: Inhibition by a proteinkinase C inhibitor and involvement of phosphoinositols. Biochem. Biophys. Res. Commun. 1989; 58: 170–176.

    Article  Google Scholar 

  53. Yanagisawa, M., Inoue, A., Ischikawa, T., Kasuya, Y, Kimura, S., Kumagaye, Nakjima, K., Watanabe, T.X., Sakakibara, S., Goto, K., Masaki, T.: Promary structure, synthesis and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide. Proc. Natl. Acad. Sci. USA 1988; 85: 6964–6967.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Nephrologisches Institut, Universität Münster, Germany

    H. Raidt, F. Baumgarten, K. Langer & U. Graefe

  2. Institut für Arterioskleroseforschung, Universität Münster, Germany

    H.-J. Bauch & W. H. Hauss

Authors
  1. H. Raidt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. Baumgarten
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H.-J. Bauch
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K. Langer
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. U. Graefe
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. W. H. Hauss
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Westdeutscher Verlag GmbH Opladen

About this chapter

Cite this chapter

Raidt, H., Baumgarten, F., Bauch, HJ., Langer, K., Graefe, U., Hauss, W.H. (1991). Parathormone, Calcium Imbalance and Atherogenesis. In: New Aspects of Metabolism and Behaviour of Mesenchymal Cells during the Pathogenesis of Arteriosclerosis. Abhandlungen der Rheinisch-Westfälischen Akademie der Wissenschaften, vol 87. VS Verlag für Sozialwissenschaften, Wiesbaden. https://doi.org/10.1007/978-3-322-99112-6_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-322-99112-6_15

  • Publisher Name: VS Verlag für Sozialwissenschaften, Wiesbaden

  • Print ISBN: 978-3-322-99114-0

  • Online ISBN: 978-3-322-99112-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation