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Abstract

The case fatality rate in patients suffering a myocardial infarction (MI) is highest within the first 24 hours of onset of symptoms. The majority of these early deaths occur before any medical attention is received either as emergency care or after admission to a hospital. This fact underscores the great potential for primary prevention. The case fatality rate falls over the course of the hospital stay and it continues to decrease over the subsequent 3–6 months. After this critical period, survivors stabilize at a risk of dying 4–8 times that faced by a comparable non-coronary population. This points to the potential value of secondary prevention.

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References

  1. Friedman, L.M., Furberg, C.D., DeMets, D.L.: Fundaments of Clinical Trials. John Wright — PSG Inc., Littleton, Mass, 1981.

    Google Scholar 

  2. May, G.S., Eberlein, K.A., Furberg, C.D., Passamani, E.R., DeMets, D.L.: Secondary prevention after myocardial infarction: A review of long-term trials. Progr. CV Diseases 24:331, 1982.

    Article  CAS  Google Scholar 

  3. Collaborative Group: Phenytoin after recovery from myocardial infarction: Controlled trial in 568 patients. Lancet 2: 1055, 1971.

    Google Scholar 

  4. Peter, T., Ross, D., Duffield, A., Luxton, M., Harper, R., Hunt, D., Sloman, G.: Effect on survival after myocardial infarction of long-term treatment with phenytoin. Br. Heart J 40: 1356, 1978.

    Article  PubMed  CAS  Google Scholar 

  5. Rydén, L., Amman, K., Conradson, T.-B., Hofvendahl, S., Mortensen, O., Smedgard, P.: Prophylaxis of ventricular tachyarrhythmias with intravenous and oral tocaninide in patients with and recovering from acute myocardial infarction. Am. Heart J 100: 1006, 1980.

    Article  PubMed  Google Scholar 

  6. Bastian, B.C., McFarland, P.W., McLauchlan, J.H., Ballantyne, D., Clark, R., Hillis, W.S., Rae, A.P., Hutton, I.: A prospective randomized trial of tocainide in patients following myocardial infarction. Am. Heart J 100: 1017, 1980.

    Article  PubMed  CAS  Google Scholar 

  7. Chamberlain, D.A., Jewitt, D.E., Julian, D.G., Campbell, R.W.F., Boyle, D. McC., Shanks, R.G.: Oral mexiletine in high-risk patients after myocardial infarction. Lancet 2: 1324, 1980.

    Article  PubMed  CAS  Google Scholar 

  8. Van Durme, J.P., Hagemeijer, F., Bogaert, M., Glaser, B., Hugenholtz, P.G.: Chronic antidysrhythmic treatment after myocardial infarction. Design of the Gent-Rotterdam Aprindine Study. In Multicenter Controlled Trials: Principles and Problems, edited by Boissel, J.P., Klimt, C.R., Paris, INSERM 76: 43, 1977.

    Google Scholar 

  9. Oliver, M.F., Boyd, G.S.: Influence of reduction of serum lipids on prognosis of coronary heart disease: Five-year study using oestrogen. Lancet 2: 499, 1961.

    Article  PubMed  CAS  Google Scholar 

  10. Stamler, J., Pick, R., Katz, L.N., Pick, A., Kaplan, B.M., Berkson, D.M., Century, D.: Effectiveness of estrogens for therapy of myocardial infarction in middle-age men. JAMA 183: 106, 1963.

    Article  Google Scholar 

  11. Leren, P.: The effect of plasma cholesterol lowering diet in male survivors of myocardial infarction. Acta Med. Scand., Suppl. 466: 1966.

    Google Scholar 

  12. Leren, P.: The Oslo Diet-Heart Study: Eleven year report. Circulation 42: 935, 1970.

    Article  PubMed  CAS  Google Scholar 

  13. Controlled trial of soya-bean oil in myocardial infarction: Report of a Research Committee to the Medical Research Council. Lancet 2: 693, 1968.

    Google Scholar 

  14. The Coronary Drug Project Research Group: Initial findings leading to modifications of its research protocol. JAMA 214: 1303, 1970.

    Article  Google Scholar 

  15. The Coronary Drug Project Research Group: Findings leading to further modifications of its protocol with respect to dextrothyroxine. JAMA 220: 996, 1972.

    Article  Google Scholar 

  16. The Coronary Drug Project Research Group: Findings leading to discontinuation of the 2.5 mg/day estrogen group. JAMA 226: 652, 1973.

    Article  Google Scholar 

  17. The Coronary Drug Project Research Group: Clofibrate and niacin in coronary heart disease. JAMA 231: 360, 1975.

    Article  Google Scholar 

  18. Detre, K.M., Shaw, L.: Long-term changes of serum cholesterol with cholesterol-altering drugs in patients with coronary heart disease: Veterans Administration Drug-Lipid Cooperative Study. Circulation 50: 998, 1974.

    Article  PubMed  CAS  Google Scholar 

  19. Five-year Study by a Group of Physicians of the Newcastle upon Tyne Region: Trial of Clofibrate in the treatment of ischaemic heart disease. Br. Med. J. 4: 767, 1971.

    Article  Google Scholar 

  20. Report by a Research Committee of the Scottish Society of Physicians: Ischaemic heart disease: A secondary prevention trial using Clofibrate: Br. Med. J. 4: 775, 1971.

    Article  Google Scholar 

  21. Carlson, L.A., Danielson, M., Ekberg, I., Klintemar, B., Rosenhamer, G.: Reduction of myocardial infarction by the combined treatment with Clofibrate and nicotinic acid. Atherosclerosis 28: 81, 1977.

    Article  PubMed  CAS  Google Scholar 

  22. Rosenhamer, G., Carlson, L.A.: Effect of combined clofibrate-nicotinic acid treatment in ischemic heart disease. Atherosclerosis 37: 129, 1980.

    Article  PubMed  CAS  Google Scholar 

  23. An assessment of long-term anticoagulant administration after cardiac infarction: Report of the Working Party on Anticoagulant Therapy in Coronary Thrombosis to the Medical Research Council. Br. Med. J. 1: 803, 1959.

    Article  Google Scholar 

  24. An assessment of long-term anticoagulant administration after cardiac infarction: Second report of the Working Party on Anticoagulant Therapy in Coronary Thrombosis to the Medical Research Council. Br. Med. J. 2: 837, 1964.

    Article  Google Scholar 

  25. Wasserman, A.J., Gutterman, L.A., Yoe, K.B., Kemp, V.E., Richardson, D.W.: Anticoagulants in acute myocardial infarction: the failure of anticoagulants to alter mortality in randomized series. Am. Heart J 71: 43, 1966.

    Article  PubMed  CAS  Google Scholar 

  26. Seaman, A.J., Griswold, H.E., Beaume, R.B., Ritzmann, L.: Long-term anticoagulant prophylaxis after myocardial infarction. N. Engl. J. Med. 281: 115, 1969.

    Article  PubMed  CAS  Google Scholar 

  27. Breddin, K.: Multicenter two-year prospective study on the prevention of secondary myocardial infarction by ASA in comparison with phenprocoumon and placebo. In Multicenter Controlled Trials: Principles and Problems, edited by Boissel, J.P., Klimt, C.R., Paris, INSERM 76: 79, 1977.

    Google Scholar 

  28. Breddin, K., Loew, D., Lechner, K., Überla, K., Walter, E.: Secondary prevention of myocardial infarction. Comparison of acetylsalicylic acid, phenprocoumon and placebo. A multicenter two-year prospective study. Thromb. Haemostas 40: 225, 1979.

    Google Scholar 

  29. The Sixty Plus Reinfarction Study Research Group: A double-blind trial to assess longterm oral anticoagulant therapy in elderly patients after myocardial infarction. Lancet 2: 989, 1980.

    Google Scholar 

  30. Elwood, P.C., Cochrane, A.L., Burt, M.L., Sweetnam, P.M., Williams, G., Welsby, E., Hughes, S.J., Renton, R.: A randomized controlled trial of acetylsalicylic acid in the secondary prevention of mortality from myocardial infarction. Br. Med. J. 1: 436, 1974.

    Article  PubMed  CAS  Google Scholar 

  31. The Coronary Drug Project Research Group: Aspirin in coronary heart disease. J. Chron. Dis. 29: 625, 1976.

    Article  Google Scholar 

  32. Elwood, P.C., Sweetnam, P.M.: Aspirin and secondary mortality after myocardial infarction. Lancet 2: 1313, 1979.

    Article  PubMed  CAS  Google Scholar 

  33. Aspirin Myocardial Infarction Study Research Group: A randomized controlled trial of aspirin in persons recovered from myocardial infarction. JAMA 243: 661, 1980.

    Article  Google Scholar 

  34. The Persantine Aspirin Reinfarction Trial Research Group: Persantine and aspirin in coronary heart disease. Circulation 62: 449, 1980.

    Article  Google Scholar 

  35. The Anturane Reinfarction Trial Research Group: Sulfinpyrazone in the prevention of cardiac death after myocardial infarction. N. Engl. J. Med. 298: 289, 1978.

    Article  Google Scholar 

  36. The Anturane Reinfarction Trial Research Group: Sulfinpyrazone in the prevention of sudden death after myocardial infarction. N. Engl. J. Med. 302: 250, 1980.

    Article  Google Scholar 

  37. Wilhelmsson, C., Vedin, J.A., Wilhelmsen, L., Tibblin, G., Werko, L.: Reduction of sudden deaths after myocardial infarction by treatment with alprenolol. Preliminary results. Lancet 2: 1157, 1974.

    Article  PubMed  CAS  Google Scholar 

  38. Vedin, A., Wilhelmsson, C., Werko, L.: Chronic alprenolol treatment of patients with acute myocardial infarction after discharge from hospital. Effects on mortality and morbidity. Acta Med. Scand., Suppl. 575: 1975.

    Google Scholar 

  39. Ahlmark, G., Saetre, H., Korsgen, M.: Reduction of sudden deaths after myocardial infarction. Lancet 2: 1563, 1974.

    Article  PubMed  CAS  Google Scholar 

  40. Ahlmark, G., Saetre, H.: Long-term treatment with beta-blockers after myocardial infarction. Europ. J. Clin. Pharmacol 10: 77, 1976.

    Article  CAS  Google Scholar 

  41. Barber, J.M., Boyle, D. McD., Chaturvedi, N.C., Singh, N., Walsh, M.J.: Practolol in acute myocardial infarction. Acta Med. Scand., Suppl. 587: 213, 1975.

    Google Scholar 

  42. Multicentre International Study: Improvement in prognosis of myocardial infarction by long-term beta-adrenoreceptor blockade using practolol. Br. Med. J. 3: 735, 1975.

    Article  Google Scholar 

  43. Multicentre International Study: Reduction in mortality after myocardial infarction with long-term beta-adrenoceptor blockade. Supplementary report. Br. Med. J. 2: 419, 1977.

    Article  Google Scholar 

  44. Andersen, M.P., Bechsgaard, P., Frederiksen, J., Hansen, D.A., Jurgensen, H.J., Nielsen, B., Pedersen, F., Pedersen-Bjergaard, O., Rasmussen, S.L.: Effect of alprenolol on mortality among patients with definite or suspected acute myocardial infarction. Lancet 2:865, 1979.

    Article  PubMed  CAS  Google Scholar 

  45. Baber, N.S., Wainwright-Evans, D., Howitt, G., Thomas, M., Wilson, C., Lewis, J.A., Dawes, P.M., Handler, K., Tuson, R.: Multicentre postinfarction trial of propranolol in 49 hospitals in the United Kingdom, Italy and Yugoslavia. Br. Heart J. 44: 96, 1980.

    Article  PubMed  CAS  Google Scholar 

  46. Wilcox, R.G., Roland, J.M., Banks, D.C., Hampton, J.R., Mitchell, J.R.A.: Randomized trial comparing propranolol with atenolol in immediate treatment of suspected myocardial infarction. Br. Med. J. 1: 885, 1980.

    Article  Google Scholar 

  47. The Norwegian Multicenter Study Group: Timolol-induced reduction in mortality and reinfarction in patients surviving acute myocardial infarction. N. Engl. J. Med. 304: 801, 1981.

    Article  Google Scholar 

  48. Sänne, H.: Exercise tolerance and physical training of non-selected patients after myocardial infarction. Acta Med. Scand., Suppl. 551: 1973.

    Google Scholar 

  49. Wilhelmsen, L., Sanne, H., Elmfeldt, D., Grimby, G., Tibblin, G., Wedel, H.: A controlled trial of physical training after myocardial infarction: Effects on risk factors, nonfatal reinfarction and death. Prevent Med. 4: 491, 1975.

    Article  CAS  Google Scholar 

  50. Kentala, E.: Physical fitness and feasibility of physical rehabilitation after myocardial infarction in men of working age. Ann. Clin. Res. 4, Suppl. 9, 1972.

    Google Scholar 

  51. Palatsi, I.: Feasibility of physical training after myocardial infarction and its effect on return to work, morbidity and mortality. Acta Med. Scand., Suppl. 599: 1976.

    Google Scholar 

  52. Kallio, V., Hamalainen, H., Hakkila, J., Luurila, O.: Reduction in sudden death by a multifactorial intervention programme after acute myocardial infarction. Lancet 2: 1091, 1979.

    Article  PubMed  CAS  Google Scholar 

  53. Naughton, J.: Exercise and myocardial infarction: The National Exercise and Heart Disease Project: An overview. Proceedings of the Workshop on Physical Conditioning and Rehabilitation, US DHSS, PHS, NIH, 1979.

    Google Scholar 

  54. Shaw, L.W. (for the National Exercise and Heart Disease Project): Effects of a prescribed supervised exercise program on mortality and cardiovascular morbidity in myocardial infarction subjects: A randomized clinical trial. Presented at the 20th Annual Conference on Cardiovascular Disease Epidemiology, San Diego, 1980.

    Google Scholar 

  55. Rechnitzer, P.A., Sangal, S., Cunningham, D.A., Andrew, G., Buck, C., Jones, N.L., Kavanagh, T., Parker, J.O., Shepherd, R.J., Yuhasz, M.S.: A controlled prospective study of the effect of endurance training on the recurrence rate of myocardial infarction: A description of the experimental design. Am. J. Epidemiol 102: 358, 1975.

    PubMed  CAS  Google Scholar 

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Furberg, C.D., May, G.S., Eberlein, K.A., Passamani, E.R., Demets, D.L. (1983). Secondary Trials After Myocardial Infarction: A Review. In: Clinical Implications of Recent Research Results in Arteriosclerosis. Abhandlungen der Rheinisch-Westfälischen Akademie der Wissenschaften, vol 70. VS Verlag für Sozialwissenschaften, Wiesbaden. https://doi.org/10.1007/978-3-322-98699-3_7

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  • DOI: https://doi.org/10.1007/978-3-322-98699-3_7

  • Publisher Name: VS Verlag für Sozialwissenschaften, Wiesbaden

  • Print ISBN: 978-3-322-98700-6

  • Online ISBN: 978-3-322-98699-3

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