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Bioresponse-Linked Analysis Based on Acetylcholinesterase Inhibition

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Book cover Bioresponse-Linked Instrumental Analysis

Part of the book series: Teubner-Reihe UMWELT ((TRU))

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Abstract

Acetylcholinesterase is a key enzyme in the nervous system. This protein is the biological target of the predominant insecticides used in agriculture and other neurotoxins such as algal toxins. Its high sensitivity, rapid turn-over, and stability promoted its use in analytical applications to detect pesticides at low concentrations in environmental samples. It is possible today to produce this enzyme recombinantly in different systems and to engineer mutated forms based on structural information and computer modeling techniques leading to a large variety of enzyme properties. In this chapter the main features of acetylcholinesterase with regard to its biotechnological use and the last developments in biosensors are presented.

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Authors and Affiliations

  1. Institute for Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany

    Till Bachmann, Jürgen Pleiss, Francois Villatte & Rolf D. Schmid

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  1. Till Bachmann
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  2. Jürgen Pleiss
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  3. Francois Villatte
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  4. Rolf D. Schmid
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Editors and Affiliations

  1. Technische Universität München, Freising-Weihenstephan, Germany

    Bertold Hock

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© 2001 B. G. Teubner GmbH, Stuttgart/Leipzig/Wiesbaden

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Bachmann, T., Pleiss, J., Villatte, F., Schmid, R.D. (2001). Bioresponse-Linked Analysis Based on Acetylcholinesterase Inhibition. In: Hock, B. (eds) Bioresponse-Linked Instrumental Analysis. Teubner-Reihe UMWELT. Vieweg+Teubner Verlag. https://doi.org/10.1007/978-3-322-86568-7_5

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  • DOI: https://doi.org/10.1007/978-3-322-86568-7_5

  • Publisher Name: Vieweg+Teubner Verlag

  • Print ISBN: 978-3-519-00316-8

  • Online ISBN: 978-3-322-86568-7

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