Skip to main content

Autonomic Dysfunction in Diabetes Mellitus

  • Chapter
Book cover Biomedical and Life Physics
  • 132 Accesses

Abstract

Diabetes Mellitus (DM) is a heterogeneous clinical syndrome characterized by hyperglycaemia and long term specific complications; neuropathy, retinopathy, and nephropathy. Diabetics have an increased incidence of ischaemic heart disease and peripheral vascular disease. A triad of neuropathy, micro and macro- angiopathy and infection operate synergistically to produce foot disease. Infection is more common in uncontrolled diabetes, especially urinary tract and genital infections. Loss of dentition is accelerated due to gingivitis and odontopalpitis. Autonomic neuropathy leads to visceral denervations producing a variety of clinical abnormalities, cardiac and respiratory dysarrhythmias, gastrointestinal motility disorders, urinary bladder dysfunction and impotence.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Report of a WHO Study Group, Prevention of diabetes mellitus, WHO Technical Report Series, 844, Geneva, 1994.

    Google Scholar 

  2. King, H., Global estimates for prevalence of diabetes mellitus and impaired glucose tolerance in adults, Diabetes Care, Vol. 16, No. 1, January 1993, pp. 157–177.

    Article  Google Scholar 

  3. Pyörälä, K., “Diabetes and Heart Disease,” in Prevention and treatment of diabetic late complications, edited by Mogensen, C.E. and Standi, E., Walterde Gruyter, Berlin, 1989, pp. 226.

    Google Scholar 

  4. Fein, S., Sonnebuck, E.H., Diabetic cardiomyopathy, Progr Cardiovasc Dis, 1985, No. 27, pp. 225–270.

    Google Scholar 

  5. Faes, T.J.C., Assessment of cardiovascular autonomic function: An inquiry into measurement, Dessertation thesis, Department of Medical Physics, Faculty of Medicine ‘Vrije Universiteit Amsterdam,’ Amsterdam, The Netherlands, 1992.

    Google Scholar 

  6. Kahn, R., Proceedings of a consensus development conference on standardized measures in diabetic neuropathy, Autonomic nervous sytem testing, Diabetes Care, 1992; No. 15, pp. 1095–1103.

    Google Scholar 

  7. Ewing, DJ., Clarke, B.F., Diagnosis and management of diabetic autonomic neuropathy, British Medical Journal, Vol. 285, 2 October 1982, pp. 916–918.

    Article  Google Scholar 

  8. Ewing, D.J., et al, The value of cardiovascular autonomic function tests: 10 years experience in diabetes, Diabetes Care, Vol. 8, No. 5, September-October 1985, pp. 491–498.

    Article  Google Scholar 

  9. Ewing, D.J., et al, Assessment of cardiovascular effects in diabetic autonomic neuropathy and prognostic implications, Annals of Internal Medicine, 1980:92 (Part 2), pp. 308–311.

    Google Scholar 

  10. Eckberg, D.L., Parasympathetic cardiovascular control in human disease: a critical review of methods and results, American Physiological Society, 1980, H581–H593.

    Google Scholar 

  11. Bianchi, A.M., et al, Time-variant power spectrum analysis for the detection of transient episodes in HRV signal, IEEE Transactions on Biomedical Engineering, Vol. 40, No. 2, February 1993, pp. 136–144.

    Article  Google Scholar 

  12. Akselrod, S., et al, Power spectrum analysis of heart rate fluctuation: A quantitative probe of beat-to-beat cardiovascular control, Science, Vol. 213, 10 July 1981, pp. 220–222.

    Article  Google Scholar 

  13. Rimoldi, O., et al, Analysis of short-term oscillations of R-R and arterial pressure in conscious dogs, American Physiological Society, 1990, H-967-H976.

    Google Scholar 

  14. Fallen, EX., et al, Power spectrum of heart rate variability: A non-invasive test of integrated neurocardiac function, Clinical and Investigative Medicine, Vol. 11, No. 5, 1988, pp. 331–340.

    Google Scholar 

  15. van Steenis, H.G., et al, Heart rate variability spectral based on non-equidistant sampling: the spectrum of counts and the instataneous heart rate spectrum, Medical Engineering Physics, Vol. 16, September 1994, pp. 355–362.

    Article  Google Scholar 

  16. Ori, Z., et al, Heart rate variability: frequency domain analysis, Cardiology Clinics, Vol. 10, No. 3, August 1992, pp. 499–537.

    Google Scholar 

  17. Rottman, J.N., et al, Efficient estimation of the heart period power spectrum suitable for physiologic or pharmacologie studies, The American Journal of Cardiology, Vol. 66, 1990, pp. 1522–1524.

    Article  Google Scholar 

  18. Eckberg, DL., et al, Defective cardiac parasympathetic control in patients with heart disease, New England Journal of Medicine, Vol. 285, No. 16, October 1974, pp. 877–873.

    Article  Google Scholar 

  19. van den Akker, T.J., et al, Heart rate variability and blood pressure oscillations in diabetics with autonomic neuropathy, Automedica, Vol. 4, 1983, pp. 201–208.

    Google Scholar 

  20. Bianchi, A., et al, Spectral analysis of heart rate variability signal and respiration in diabetic subjects, Medical & Biological Engineering & Computing, Vol. 28, 1990, pp. 205–211.

    Article  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH, Braunschweig/Wiesbaden

About this chapter

Cite this chapter

El Mugamer, I.T., Desai, K.D., Towsey, M., Ghista, D.M. (1996). Autonomic Dysfunction in Diabetes Mellitus. In: Ghista, D.N. (eds) Biomedical and Life Physics. Vieweg+Teubner Verlag. https://doi.org/10.1007/978-3-322-85017-1_45

Download citation

  • DOI: https://doi.org/10.1007/978-3-322-85017-1_45

  • Publisher Name: Vieweg+Teubner Verlag

  • Print ISBN: 978-3-322-85019-5

  • Online ISBN: 978-3-322-85017-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics