Secretome: Pharmaceuticals for Cell-Free Regenerative Therapy

Haque, Nazmul; Abdullah, Basri Johan Jeet; Kasim, Noor Hayaty Abu

doi:10.1007/978-3-319-99328-7_2

Nazmul Haque^3,4,
Basri Johan Jeet Abdullah⁵ &
Noor Hayaty Abu Kasim⁶

Part of the book series: Stem Cells in Clinical Applications ((SCCA))

580 Accesses
4 Citations

Abstract

Stem cells are currently considered to be the best tool for regenerative medicine because of their self-renewal capability and plasticity. It was assumed that the outcomes of cell-based regenerative therapies are achieved due to the engraftment and differentiation of stem cells into targeted cells within the tissues. In recent years, several studies have reported positive outcomes of cell-based therapies despite of insufficient engraftment of transplanted cells. These findings have created a huge interest in the regenerative potential of paracrine factors released from the transplanted stem or progenitor cells. Interestingly, this notion has also led scientists to question the role of proteins in the secretome produced by cells, tissues or organisms under a certain condition or at a particular time for regenerative therapy. Although secretomes can potentially play a vital role in the regeneration process through paracrine signaling, secretome from a particular cell type cannot be the panacea for all diseases. In this review, we attempt to discuss the regenerative potential of secretomes secreted by different cell types for the treatment of different diseases from the molecular point of view. In addition, we also describe the role of pretreatment of cells to produce secretomes enriched with selective paracrine factors that could be designed specifically for a targeted regenerative therapy.

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Abbreviations

AD-MSC:: Adipose tissue-derived MSCs
AFSCs:: Amniotic fluid stem cells
ALT:: Alanine aminotransferase
AMI:: Acute myocardial infarction
AM-MSCs:: Amniotic membrane-derived MSCs
ANGPTs:: Angiopoietins
AP-MSCs:: Apical papilla-derived MSCs
Apo-PBMC:: Apoptotic PBMC
AST:: Aspartate aminotransferase
BDNF:: Brain-derived neurotrophic factor
BMC:: Bone marrow cells
BM-MSCs:: MSCs from bone-marrow
BMP4:: Bone morphogenetic protein 4
CNS:: Central nervous system
CREB:: cAMP response element-binding protein
DPSCs:: Dental pulp-derived MSCs
EGF:: Epidermal growth factor
eNOS:: Endothelial nitric oxide synthase
Erk1/2:: Extracellular-signal regulated kinase
ESC-MSCs:: ESC-derived MSCs
ESCs:: Embryonic stem cells
FB:: Human fibroblasts
FGF:: Fibroblast growth factor
G-CSF:: Granulocyte colony stimulating factor
GDN:: Glia-derived nexin
GDNF:: Glial cell line-derived neurotrophic factor
GM-CSF:: Granulocyte-macrophage colony stimulating factor
HDF:: Human dermal fibroblast
HGF:: Hepatocyte growth factor
HIF-1a:: Hypoxia-inducible factor 1-alpha
HSP27:: Heat shock protein 27
HUCPVC-MSCs:: Human umbilical cord perivascular cell-derived MSCs
HUVECs:: Human umbilical vein epithelial cells
IFN-γ:: Interferon-gamma
IGF-1:: Insulin-like growth factor 1
IGFBP2:: Insulin-like growth factor binding protein 2
IL:: Interleukin
iNOS:: Inducible nitric oxide synthase
KC:: Keratinocytes
KGF:: Keratinocyte growth factor
LIF:: Leukemia inhibitory factor
LPS:: Lipopolysaccharides
MCP-1:: Monocyte chemoattractant protein 1
M-CSF:: Macrophage colony stimulating factor
MSCs:: Mesenchymal stem cells
OM-MSCs:: Olfactory mucosal MSCs
PBL:: Peripheral blood leukocytes
PBMC:: Peripheral blood mononuclear cells
PCNA:: Proliferating cell nuclear antigen
PDGF-BB:: Platelet-derived growth factor beta
PEDF:: Pigment epithelium-derived factor
SCF:: Stem cell factor
SDF-1:: Stromal cell-derived factor-1
SM-MSCs:: Skeletal muscle MSCs
sTNFR-1:: Soluble TNF receptor 1
TGFβ:: Transforming growth factor β
TNF-α:: Tumor necrosis factor alpha
UT-MSCs:: Uterine tubes MSCs
VEGF-A:: Vascular endothelial growth factor A

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Acknowledgment

This work was supported by High Impact Research MOHE Grant UM.C/625/1/HIR/MOHE/DENT/01 from the Ministry of Higher Education Malaysia and University of Malaya Research Grant UMRG RP019/13HTM.

Conflicts of Interest: The authors confirm that there are no conflicts of interest related to this study.

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Authors and Affiliations

Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia
Nazmul Haque
Department of Oral Biology and Biomedical Sciences, Faculty of Dentistry, MAHSA University, Selangor, Malaysia
Nazmul Haque
Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Basri Johan Jeet Abdullah
Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia
Noor Hayaty Abu Kasim

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Nazmul Haque
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Basri Johan Jeet Abdullah
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Noor Hayaty Abu Kasim
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Correspondence to Noor Hayaty Abu Kasim .

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Laboratory of Stem Cell Research & Application, University of Science, Vietnam National University, Ho Chi Minh, Vietnam
Phuc Van Pham

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Haque, N., Abdullah, B.J.J., Kasim, N.H.A. (2018). Secretome: Pharmaceuticals for Cell-Free Regenerative Therapy. In: Pham, P. (eds) Stem Cell Drugs - A New Generation of Biopharmaceuticals. Stem Cells in Clinical Applications. Springer, Cham. https://doi.org/10.1007/978-3-319-99328-7_2

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DOI: https://doi.org/10.1007/978-3-319-99328-7_2
Published: 26 October 2018
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-99327-0
Online ISBN: 978-3-319-99328-7
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