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3D Printing Technology for Vascularization

  • Enoch Yeung
  • Pooja Yesantharao
  • Chin Siang Ong
  • Narutoshi Hibino
Chapter
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

Abstract

Regenerative medicine has taken the forefront in driving medical innovation over the past few decades. Encompassing a wide variety of disciplines, regenerative medicine techniques are successfully employed to repair organs and restore native tissue function. Of particular importance are tissue engineering methodologies, such as 3D printing, which are used to fabricate tissue constructs with native-like function. Vascular tissue engineering poses even greater challenges, however, because of the complex geometries and microscale structures involved. This chapter presents various 3D printing methodologies and their current applications in the fabrication of vascular tissues. In doing so, this chapter also highlights current challenges in the field of vascular tissue engineering and points to areas for future research.

Keywords

3D printing Vascular tissue engineering TEVG Bioprinting 

References

  1. 1.
    Baudis, S., Nehl, F., Ligon, S. C., Nigisch, A., Bergmeister, H., Bernhard, D., et al. (2011). Elastomeric degradable biomaterials by photopolymerization-based CAD-CAM for vascular tissue engineering. Biomedical Materials, 6(5), 055003.ADSCrossRefGoogle Scholar
  2. 2.
    Blaeser, A., et al. (2013). Biofabrication under fluorocarbon: A novel freeform fabrication technique to generate high aspect ratio tissue-engineered constructs. Bioresearch Open Access, 2(5), 374–384.CrossRefGoogle Scholar
  3. 3.
    Colosi, C., et al. (2016). Microfluidic bioprinting of heterogeneous 3D tissue constructs using low-viscosity bioink. Advanced Materials, 28(4), 677–684.CrossRefGoogle Scholar
  4. 4.
    Cui, X., & Boland, T. (2009). Human microvasculature fabrication using thermal inkjet printing technology. Biomaterials, 30(31), 6221–6227.CrossRefGoogle Scholar
  5. 5.
    Cui, X., et al. (2012). Thermal inkjet printing in tissue engineering and regenerative medicine. Recent Patents on Drug Delivery & Formulation, 6(2), 149–155.CrossRefGoogle Scholar
  6. 6.
    Dahl, S. L., et al. (2007). Mechanical properties and compositions of tissue engineered and native arteries. Annals of Biomedical Engineering, 35(3), 348–355.CrossRefGoogle Scholar
  7. 7.
    Datta, P., Ayan, B., & Ozbolat, I. T. (2017). Bioprinting for vascular and vascularized tissue biofabrication. Acta Biomaterialia, 51, 1–20.CrossRefGoogle Scholar
  8. 8.
    Dernowsek, J. A., et al. (2016). Tissue spheroids encaged into microscaffolds with internal structure to increase cell viability. Procedia CIRP, 49, 174–177.CrossRefGoogle Scholar
  9. 9.
    Domingos, M., et al. (2013). The first systematic analysis of 3D rapid prototyped poly(ε-caprolactone) scaffolds manufactured through BioCell printing: The effect of pore size and geometry on compressive mechanical behaviour and in vitro hMSC viability. Biofabrication, 5(4), 045004.ADSCrossRefGoogle Scholar
  10. 10.
    Du, V., et al. (2015). Magnetic engineering of stable rod-shaped stem cell aggregates: Circumventing the pitfall of self-bending. Integrative Biology (Cambridge), 7(2), 170–177.CrossRefGoogle Scholar
  11. 11.
    Duarte Campos, D. F., et al. (2013). Three-dimensional printing of stem cell-laden hydrogels submerged in a hydrophobic high-density fluid. Biofabrication, 5(1), 015003.ADSCrossRefGoogle Scholar
  12. 12.
    Duarte Campos, D. F., et al. (2015). The stiffness and structure of three-dimensional printed hydrogels direct the differentiation of mesenchymal stromal cells toward adipogenic and osteogenic lineages. Tissue Engineering Part A, 21(3–4), 740–756.CrossRefGoogle Scholar
  13. 13.
    Ferris, C. J., et al. (2013). Biofabrication: An overview of the approaches used for printing of living cells. Applied Microbiology and Biotechnology, 97(10), 4243–4258.CrossRefGoogle Scholar
  14. 14.
    Fukunishi, T., et al. (2017). Preclinical study of patient-specific cell-free nanofiber tissue-engineered vascular grafts using 3-dimensional printing in a sheep model. The Journal of Thoracic and Cardiovascular Surgery, 153(4), 924–932.CrossRefGoogle Scholar
  15. 15.
    Gao, Q., et al. (2015). Coaxial nozzle-assisted 3D bioprinting with built-in microchannels for nutrients delivery. Biomaterials, 61, 203–215.CrossRefGoogle Scholar
  16. 16.
    Gudapati, H., Dey, M., & Ozbolat, I. (2016). A comprehensive review on droplet-based bioprinting: Past, present and future. Biomaterials, 102, 20–42.CrossRefGoogle Scholar
  17. 17.
    Guillemot, F., et al. (2011). Laser-assisted bioprinting to deal with tissue complexity in regenerative medicine. MRS Bulletin, 36(12), 1015–1019.CrossRefGoogle Scholar
  18. 18.
    Guillotin, B., et al. (2010). Laser assisted bioprinting of engineered tissue with high cell density and microscale organization. Biomaterials, 31(28), 7250–7256.CrossRefGoogle Scholar
  19. 19.
    Guo, Y., et al. (2017). Inkjet and inkjet-based 3D printing: Connecting fluid properties and printing performance. Rapid Prototyping Journal, 23(3), 562–576.CrossRefGoogle Scholar
  20. 20.
    Hajdu, Z., et al. (2010). Tissue spheroid fusion-based in vitro screening assays for analysis of tissue maturation. Journal of Tissue Engineering and Regenerative Medicine, 4(8), 659–664.CrossRefGoogle Scholar
  21. 21.
    Harrison, J. H., Merrill, J. P., & Murray, J. E. (1956). Renal homotransplantation in identical twins. Surgical Forum, 6, 432–436.Google Scholar
  22. 22.
    Irvine, S. A., & Venkatraman, S. S. (2016). Bioprinting and differentiation of stem cells. Molecules, 21(9), E1188.CrossRefGoogle Scholar
  23. 23.
    Itoh, M., et al. (2015). Scaffold-free tubular tissues created by a bio-3D printer undergo remodeling and endothelialization when implanted in rat Aortae. PLoS One, 10(9), e0136681.CrossRefGoogle Scholar
  24. 24.
    Jia, W., et al. (2016). Direct 3D bioprinting of perfusable vascular constructs using a blend bioink. Biomaterials, 106, 58–68.CrossRefGoogle Scholar
  25. 25.
    Kelm, J. M., et al. (2006). Design of custom-shaped vascularized tissues using microtissue spheroids as minimal building units. Tissue Engineering, 12(8), 2151–2160.CrossRefGoogle Scholar
  26. 26.
    Kesari, P., Xu, T., & Boland, T. (2004). Layer-by-layer printing of cells and its application to tissue engineering. MRS Proceedings, 845, AA4.5.CrossRefGoogle Scholar
  27. 27.
    Khalil, S., & Sun, W. (2009). Bioprinting endothelial cells with alginate for 3D tissue constructs. Journal of Biomechanical Engineering, 131(11), 111002.CrossRefGoogle Scholar
  28. 28.
    Kolesky, D. B., et al. (2014). 3D bioprinting of vascularized, heterogeneous cell-laden tissue constructs. Advanced Materials, 26(19), 3124–3130.CrossRefGoogle Scholar
  29. 29.
    Kolesky, D. B., et al. (2016). Three-dimensional bioprinting of thick vascularized tissues. Proceedings of the National Academy of Sciences of the United States of America, 113(12), 3179–3184.ADSCrossRefGoogle Scholar
  30. 30.
    Kucukgul, C., et al. (2015). 3D bioprinting of biomimetic aortic vascular constructs with self-supporting cells. Biotechnology and Bioengineering, 112(4), 811–821.CrossRefGoogle Scholar
  31. 31.
    Langer, R., & Vacanti, J. P. (1993). Tissue engineering. Science, 260(5110), 920–926.ADSCrossRefGoogle Scholar
  32. 32.
    Lee, V. K., et al. (2014). Creating perfused functional vascular channels using 3D bio-printing technology. Biomaterials, 35(28), 8092–8102.CrossRefGoogle Scholar
  33. 33.
    Lee, V. K., et al. (2014). Generation of multi-scale vascular network system within 3D hydrogel using 3D bio-printing technology. Cellular and Molecular Bioengineering, 7(3), 460–472.MathSciNetCrossRefGoogle Scholar
  34. 34.
    Lee, V. K., et al. (2015). 3D bioprinting and 3D imaging for stem cell engineering. In K. Turksen (Ed.), Bioprinting in regenerative medicine (pp. 33–66). Cham: Springer.CrossRefGoogle Scholar
  35. 35.
    Melchiorri, A. J., et al. (2016). 3D-printed biodegradable polymeric vascular grafts. Advanced Healthcare Materials, 5(3), 319–325.CrossRefGoogle Scholar
  36. 36.
    Meyer, W., et al. (2012). Soft polymers for building up small and smallest blood supplying systems by stereolithography. Journal of Functional Biomaterials, 3(2), 257–268.CrossRefGoogle Scholar
  37. 37.
    Murphy, S. V., & Atala, A. (2014). 3D bioprinting of tissues and organs. Nature Biotechnology, 32(8), 773–785.CrossRefGoogle Scholar
  38. 38.
    Nakamura, M., Nishiyama, Y., & Henmi, C. 2008. 3D micro-fabrication by inkjet 3D biofabrication for 3D tissue engineering. In 2008 International Symposium on Micro-Nano Mechatronics and Human Science.Google Scholar
  39. 39.
    Nishiyama, Y., et al. (2008). Ink jet three-dimensional digital fabrication for biological tissue manufacturing: Analysis of alginate microgel beads produced by ink jet droplets for three dimensional tissue fabrication. Journal of Imaging Science and Technology, 52(6), 60201-1–60201-6.Google Scholar
  40. 40.
    Nishiyama, Y., et al. (2008). Development of a three-dimensional bioprinter: construction of cell supporting structures using hydrogel and state-of-the-art inkjet technology. Journal of Biomechanical Engineering, 131(3), 035001–035001-6.CrossRefGoogle Scholar
  41. 41.
    Norotte, C., et al. (2009). Scaffold-free vascular tissue engineering using bioprinting. Biomaterials, 30(30), 5910–5917.CrossRefGoogle Scholar
  42. 42.
    Ozbolat, I. T. (2015). Scaffold-based or scaffold-free bioprinting: Competing or complementing approaches? Journal of Nanotechnology in Engineering and Medicine, 6(2), 024701–024701-6.CrossRefGoogle Scholar
  43. 43.
    Ozbolat, I. T. (2017). 3D bioprinting: Fundamentals, principles and applications. New York: Elsevier.Google Scholar
  44. 44.
    Ozbolat, I. T., Moncal, K. K., & Gudapati, H. (2017). Evaluation of bioprinter technologies. Additive Manufacturing, 13(Suppl C), 179–200.CrossRefGoogle Scholar
  45. 45.
    Poldervaart, M. T., et al. (2013). Sustained release of BMP-2 in bioprinted alginate for osteogenicity in mice and rats. PLoS One, 8(8), e72610.ADSCrossRefGoogle Scholar
  46. 46.
    Richards, D., et al. (2017). 3D bioprinting for vascularized tissue fabrication. Annals of Biomedical Engineering, 45(1), 132–147.CrossRefGoogle Scholar
  47. 47.
    Siallagan, D., et al. (2017). Virtual surgical planning, flow simulation, and 3-dimensional electrospinning of patient-specific grafts to optimize Fontan hemodynamics. The Journal of Thoracic and Cardiovascular Surgery, 155(4), 1734–1742.CrossRefGoogle Scholar
  48. 48.
    Tan, Y., et al. (2014). 3D printing facilitated scaffold-free tissue unit fabrication. Biofabrication, 6(2), 024111.ADSCrossRefGoogle Scholar
  49. 49.
    Wang, X., et al. (2016). 3D bioprinting technologies for hard tissue and organ engineering. Materials (Basel), 9(10), 802.ADSCrossRefGoogle Scholar
  50. 50.
    Wu, P. K., & Ringeisen, B. R. (2010). Development of human umbilical vein endothelial cell (HUVEC) and human umbilical vein smooth muscle cell (HUVSMC) branch/stem structures on hydrogel layers via biological laser printing (BioLP). Biofabrication, 2(1), 014111.ADSCrossRefGoogle Scholar
  51. 51.
    Wu, W., DeConinck, A., & Lewis, J. A. (2011). Omnidirectional printing of 3D microvascular networks. Advanced Materials, 23(24), H178–H183.CrossRefGoogle Scholar
  52. 52.
    Xiaohong, W., Kai, H., & Weiming, Z. (2013). Optimizing the fabrication processes for manufacturing a hybrid hierarchical polyurethane–cell/hydrogel construct. Journal of Bioactive and Compatible Polymers, 28(4), 303–319.CrossRefGoogle Scholar
  53. 53.
    Xu, C., et al. (2012). Scaffold-free inkjet printing of three-dimensional zigzag cellular tubes. Biotechnology and Bioengineering, 109(12), 3152–3160.CrossRefGoogle Scholar
  54. 54.
    Zhang, Y. S., et al. (2016). Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip. Biomaterials, 110, 45–59.CrossRefGoogle Scholar
  55. 55.
    Zhao, L., et al. (2012). The integration of 3-D cell printing and mesoscopic fluorescence molecular tomography of vascular constructs within thick hydrogel scaffolds. Biomaterials, 33(21), 5325–5332.CrossRefGoogle Scholar
  56. 56.
    Zhu, W., et al. (2017). Direct 3D bioprinting of prevascularized tissue constructs with complex microarchitecture. Biomaterials, 124, 106–115.ADSCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Enoch Yeung
    • 1
  • Pooja Yesantharao
    • 1
  • Chin Siang Ong
    • 1
  • Narutoshi Hibino
    • 1
  1. 1.Division of Cardiac Surgery, Johns Hopkins HospitalBaltimoreUSA

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