Pain pp 1127-1130 | Cite as

Biopharmacologic and Neurophysiologic Basis of Addiction

  • Randall T. BrownEmail author


Addiction, or “substance use disorder (SUD),” is characterized by maladaptive substance use that is associated with adverse consequences in term of mental, physical, and social functioning. The state of addiction is associated with predictable alterations of central nervous system (CNS) function and neurobiology that, in turn, are predictive of behavioral patterns and functional declines. As such, SUDs are accurately characterized as a chronic relapsing disease of the brain.


Substance use disorder Addiction Neurobiology 


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    Herron AJ, Brennan TK, editors. ASAM Essentials of Addiction Medicine: Lippincott, Williams, and Wilkins, Philadelphia, PA. 2015.Google Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Family Medicine and Community HealthUniversity of Wisconsin School of Medicine and Public HealthMadisonUSA

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