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Neuroendocrine Neoplasms

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Mediastinal Pathology
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Abstract

Primary mediastinal neuroendocrine neoplasms, as they are referred to in this chapter, encompass several tumors that do not necessarily share the same histogenesis, biologic behavior, or treatment modalities. In addition, some of these tumors may in turn occur as ectopically placed tissues that may be deposited in the mediastinal compartment. In some of these cases, the embryologic development may be the clue to their occurrence. Nevertheless, this group of tumors ranges from the benign tumors to the overtly high-grade malignancy. Basically, the group of tumors that more often present as mediastinal tumors are neuroendocrine carcinomas (well-differentiated neuroendocrine carcinoma (carcinoid tumor), moderately differentiated neuroendocrine carcinoma (atypical carcinoid), poorly differentiated neuroendocrine carcinoma (small cell carcinoma and large cell neuroendocrine carcinoma), paragangliomas, parathyroid tumors (parathyroid adenoma, parathyroid carcinoma), thyroid tumors (intrathoracic goiter, thyroid carcinoma). This chapter will be presented from the practical point of view for the practicing pathologist who may be called upon to interpret these tumors. Clinical, pathological, histopathological, immunohistochemical, radiological, gross, molecular features will be discussed, as well as differential diagnoses and staging.

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Kalhor, N., Moran, C. (2019). Neuroendocrine Neoplasms. In: Mediastinal Pathology . Springer, Cham. https://doi.org/10.1007/978-3-319-98980-8_9

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