Skip to main content

Primary Malignant Tumors

  • Chapter
  • First Online:
Spine Surgery
  • 99k Accesses

Abstract

Primary malignant bone tumors of the spine (i.e., vertebral sarcomas, not plasmocytomas) are very rare entities and account for only 5–10% of all primary malignant bone tumors of the entire skeleton.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Kelley SP, Ashford RU, Rao AS, Dickson RA. Primary bone tumours of the spine: a 42-year survey from the Leeds Regional Bone Tumour Registry. Eur Spine J. 2007;16:405–9.

    Article  Google Scholar 

  2. Moore DD. Haydon RC Ewing’s sarcoma of bone. Cancer Treat Res. 2014;162:93–115.

    Article  Google Scholar 

  3. Ewing J. Diffuse endothelioma of bone. Proc NY Pathol Soc. 1921;21:17–24.

    Google Scholar 

  4. Esiashvili N, Goodman M, Marcus RB Jr. Changes in incidence and survival of Ewing sarcoma patients over the past 3 decades: surveillance epidemiology and end results data. J Pediatr Hematol Oncol. 2008;30(6):425–30.

    Article  Google Scholar 

  5. Freyschmidt J, Jundt G, Ostertag H. Knochentumoren: Klinik, Radiologie, Pathologie. Berlin/Heidelberg/New York: Springer; 2003.

    Google Scholar 

  6. Kim HJ, McLawhorn AS, Goldstein MJ, Boland PJ. Malignant osseous tumors of the pediatric spine. J Am Acad Orthop Surg. 2012;20(10):646–56.

    PubMed  Google Scholar 

  7. Caudill JS, Arndt CA. Diagnosis and management of bone malignancy in adolescence. Adolesc Med State Art Rev. 2007;18(1):62–78. ix.

    PubMed  Google Scholar 

  8. West DC. Ewing sarcoma family of tumors. Curr Opin Oncol. 2000;12(4):323–9.

    Article  CAS  Google Scholar 

  9. Schaser KD, Melcher I, Druschel C, Tsitsilonis S, Disch AC. Surgical management of thoracolumbar spinal sarcoma. Orthopade. 2012;41(8):659–73.

    Article  Google Scholar 

  10. Balamuth NJ, Womer RB. Ewing’s sarcoma. Lancet Oncol. 2010;11(2):184–92. https://doi.org/10.1016/S1470-2045(09)70286-4.

    Article  CAS  PubMed  Google Scholar 

  11. Hoffmann C, Ahrens S, Dunst J, et al. Pelvic Ewing sarcoma: a retrospective analysis of 241 cases. Cancer. 1999;85(4):869–77.

    Article  CAS  Google Scholar 

  12. Frisch S, Timmermann B. The evolving role of proton beam therapy for sarcomas. Clin Oncol (R Coll Radiol). 2017;29(8):500–6.

    Article  CAS  Google Scholar 

  13. Flanagan AMYT. Chordoma. In: Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F, editors. World Health Organization classification of tumours. Pathology and genetics of tumours of soft tissue andbone. Lyon: IARC Press; 2013. p. S328–9.

    Google Scholar 

  14. McMaster ML, Goldstein AM, Bromley CM, Ishibe N, Parry DM. Chordoma: incidence and survival patterns in the United States, 1973–1995. Cancer Causes Control. 2001;12:1–11.

    Article  CAS  Google Scholar 

  15. Lauer SR, Edgar MA, Gardner JM, Sebastian A, Weiss SW. Soft tissue chordomas: a clinicopathologic analysis of 11 cases. Am J Surg Pathol. 2013;37:719–26.

    Article  Google Scholar 

  16. Bergh P, Kindblom LG, Gunterberg B, et al. Prognostic factors in chordoma of the sacrum and mobile spine: a study of 39 patients. Cancer. 2000;88:2122–34.

    Article  CAS  Google Scholar 

  17. Stacchiotti S, Sommer J, Chordoma Global Consensus Group. Building a global consensus approach to chordoma: a position paper from the medical and patient community. Lancet Oncol. 2015;16(2):e71–83.

    Article  Google Scholar 

  18. Stacchiotti S, Casali PG, Vullo SL. Chordoma of the mobile spine and sacrum: a retrospective analysis of a series of patients surgically treated at two referral centers. Ann Surg Oncol. 2010;17:211–9.

    Article  Google Scholar 

  19. Walcott BP, Nahed BV, Mohyeldin A, Coumans JV, Kahle KT, Ferreira MJ. Chordoma: current concepts, management, and future directions. Lancet Oncol. 2012;13:e69–76.9.

    Article  Google Scholar 

  20. Rotondo RL, et al. High-dose proton-based radiation therapy in the management of spine chordomas: Outcomes and clinicopathological prognostic factors. J Neurosurg Spine. 2015;23:788–97.

    Article  Google Scholar 

  21. De Amorim Bernstein K, DeLaney T. Chordomas and chondrosarcomas-the role of radiation therapy. J Surg Oncol. 2016;114(5):564–9. https://doi.org/10.1002/jso.24368. Epub 2016 Oct 19.

    Article  PubMed  Google Scholar 

  22. Chen YL, et al. Definitive high-dose photon/proton radiotherapy for unresected mobile spine and sacral chordomas. Spine (Phila Pa 1976). 2013;38:E930–6.

    Article  Google Scholar 

  23. Imai R, et al. Carbon ion radiotherapy for unresectable sacral chordomas. Clin Cancer Res. 2004;10:5741–6.

    Article  CAS  Google Scholar 

  24. Varga PP, Szövérfi Z, Fisher CG, Boriani S, Gokaslan ZL, Dekutoski MB, Chou D, Quraishi NA, Reynolds JJ, Luzzati A, Williams R, Fehlings MG, Germscheid NM, Lazary A, Rhines LD. Surgical treatment of sacral chordoma: prognostic variables for local recurrence and overall survival. Eur Spine J. 2015;24(5):1092–101.

    Article  Google Scholar 

  25. Stacchiotti S, Casali PG. Systemic therapy options for unresectable and metastatic chordomas. Curr Oncol Rep. 2011;13:323–30.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Marcus Rickert .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Rickert, M., Rauschmann, M. (2019). Primary Malignant Tumors. In: Meyer, B., Rauschmann, M. (eds) Spine Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-98875-7_47

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-98875-7_47

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-98874-0

  • Online ISBN: 978-3-319-98875-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics