Precursors of Endometrial Carcinoma

  • Tricia A. Murdock
  • Emanuela F. T. Veras
  • Robert J. Kurman
  • Michael T. Mazur


It has been well recognized since the 1970s that unopposed estrogenic stimulation leads to endometrial hyperplasia, which in turn has the potential to progress to the usual type of endometrial carcinoma, termed “endometrioid carcinoma.” More recently, another lesion designated “endometrial intraepithelial carcinoma (EIC)” has been shown to precede the development of invasive uterine serous carcinoma (USC). Because of its association with USC and not endometrioid carcinoma, it has been proposed that endometrial intraepithelial carcinoma be designated “serous endometrial intraepithelial carcinoma.” This chapter discusses the various types of endometrial carcinoma precursors and focuses on their mimickers. The World Health Organization’s WHO Classification of Tumours of the Female Reproductive Organs was revised in 2014, and several changes were made. This chapter reflects those changes.


Endometrial carcinoma Endometrial hyperplasia Endometrioid intraepithelial neoplasia Epithelial cytoplasmic carcinoma Atypical hyperplasia of endometrium Serous endometrial intraepithelial carcinoma 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Tricia A. Murdock
    • 1
  • Emanuela F. T. Veras
    • 1
  • Robert J. Kurman
    • 1
  • Michael T. Mazur
    • 2
  1. 1.Department of PathologyThe Johns Hopkins HospitalBaltimoreUSA
  2. 2.Department of Pathology and Laboratory MedicineState University of New York Upstate Medical UniversitySyracuseUSA

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