• Tricia A. Murdock
  • Emanuela F. T. Veras
  • Robert J. Kurman
  • Michael T. Mazur


Most endometrial polyps appear to originate from localized overgrowth of the basalis with glands and stroma participating in the lesion. The pathogenesis of polyps has not been firmly established although molecular mechanisms have been invoked in several studies, and it is suggested that polyps originate as a monoclonal stromal overgrowth with secondary endometrial gland proliferation. The abnormality results in a disorganized growth comprised of endometrial glands, stroma, and vessels which may be polypoid or sessile, possibly over a large portion of the endometrium. The pathogenesis of endometrial polyps appears to be linked to imbalances between endometrial proliferation and apoptosis, as well as molecular alterations of the HMGI-C gene and specific clonal rearrangements.


Endometrial polyps Atypical polypoid adenomyoma Adhesions Polyps of the endometrium 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Tricia A. Murdock
    • 1
  • Emanuela F. T. Veras
    • 1
  • Robert J. Kurman
    • 1
  • Michael T. Mazur
    • 2
  1. 1.Department of PathologyThe Johns Hopkins HospitalBaltimoreUSA
  2. 2.Department of Pathology and Laboratory MedicineState University of New York Upstate Medical UniversitySyracuseUSA

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