Gestational Trophoblastic Disease

  • Tricia A. Murdock
  • Emanuela F. T. Veras
  • Robert J. Kurman
  • Michael T. Mazur


The World Health Organization (WHO) classification of gestational trophoblastic disease (GTD) includes disorders of placental development (hydatidiform mole) and neoplasms of the trophoblast (choriocarcinoma, placental site trophoblastic tumor [PSTT], and epithelioid trophoblastic tumor [ETT]). Nonneoplastic lesions include the exaggerated placental site and placental site nodules and plaques. A common feature of all trophoblastic lesions is that they produce human chorionic gonadotropin (hCG), which serves as a clinical marker for the presence of persistent or progressive trophoblastic disease. Because these lesions, especially postmolar trophoblastic disease, are often treated in the absence of a histologic diagnosis, they may be clinically classified as GTD without designation of the morphologic subtype. Nonetheless, identification and separation of the different pathologic forms of the disease are important, as they have different clinical presentations and behavior.


Gestational trophoblastic disease Hydatidiform mole Non-molar villous lesions Invasive hydatidiform mole Choriocarcinoma Placental site trophoblastic tumor Epithelioid trophoblastic tumor Placental site nodule and plaque 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Tricia A. Murdock
    • 1
  • Emanuela F. T. Veras
    • 1
  • Robert J. Kurman
    • 1
  • Michael T. Mazur
    • 2
  1. 1.Department of PathologyThe Johns Hopkins HospitalBaltimoreUSA
  2. 2.Department of Pathology and Laboratory MedicineState University of New York Upstate Medical UniversitySyracuseUSA

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