Abstract
Oligodendroglioma represents the second major category of diffuse gliomas, accounting for 3–4% of all primary brain tumors. There are two WHO grades of oligodendroglioma that are significant predictors of survival: grade II or well-differentiated tumors and grade III or anaplastic oligodendroglioma. Frozen sections of oligodendrogliomas almost invariably produce misleading cytoplasmic and nuclear artifacts, which is why the cytologic technique is preferable for intraoperative consultation. This chapter reviews the cytomorphologic features and intraoperative differential diagnosis of oligodendroglioma and anaplastic oligodendroglioma.
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Eckel-Passow JE, Lachance DH, Molinaro AM, Kyle M, et al. Glioma groups based on 1p/19q, IDH, and TERT promoter mutations in tumors. N Engl J Med. 2015;372:2499–508.
Goh SGN, Chuah KL. Role of intraoperative smear cytology in the diagnosis of anaplastic oligodendroglioma. Acta Cytol. 2003;47:293–8.
Kim YH, Nobusawa S, Mittelbronn M, Paulus W, et al. Molecular classification of low-grade diffuse gliomas. Am J Pathol. 2010;177:2708–14.
Klysik M, Gavito J, Boman D, Miranda RN, Hanbali F, De Las Casas LE. Intraoperative imprint cytology of central neurocytoma: The great oligodendroglioma mimicker. Diagn Cytopathol. 2010;38:202–7.
Koeller KK, Rushing EJ. From the archives of the AFIP: Oligodendroglioma and its variants: radiologic-pathologic correlations. Radiographics. 2005;25:1669–88.
Kreiger PA, Okada Y, Simon S, Rorke LB, Louis DN, Golden JA. Losses of chromosomes 1p and 19q are rare in pediatric oligodendrogliomas. Acta Neuropathol (Berl). 2005;109:387–92.
Mitsuhashi T, Shimizu Y, Ban S, Ogawa F, Matsutani M, Shimizu M, Hirose T. Anaplastic oligodendroglioma. A case report with characteristic cytologic features including minigemistocytes. Acta Cytol. 2007;51:657–60.
Monabati A, Kumar PV, Roozbehi H, Torabinezhad S. Cytologic findings in metastatic oligodendroglioma. Acta Cytol. 2003;47:702–4.
Nguyen GK, Jonson ES, Mielke BW. Comparative cytomorphology of pituitary adenomas and oligodendrogliomas in intraoperative crush preparations. Acta Cytol. 1992;36:661–7.
Park J-Y, Suh Y-L, Han J. Disembryoplastic neuroepithelial tumor. Features distinguishing it from oligodendroglioma on cytologic squash preparations. Acta Cytol. 2003;47:624–9.
Sahm F, Reuss D, Koelsche C, Capper D, et al. Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma. Acta Neuropath. 2014;128:551–9.
Watanabe T, Nobusawa S, Kleihues P, Ohgaki H. IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas. Am J Pathol. 2009;174:1149–53.
Wesseling P, van den Bent M, Perry A. Oligodendroglioma: pathology, molecular mechanisms and markers. Acta Neuropathol. 2015;129:809–27.
Yan H, Parsons DW, Jin G, McLendon R, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med. 2009;360:765–73.
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Lacruz, C.R., Saénz de Santamaría, J., Bardales, R.H. (2018). Oligodendroglial Tumors. In: Central Nervous System Intraoperative Cytopathology. Essentials in Cytopathology, vol 13. Springer, Cham. https://doi.org/10.1007/978-3-319-98491-9_7
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DOI: https://doi.org/10.1007/978-3-319-98491-9_7
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