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Adipose-Derived Stem Cells to Facilitate Ulcer Healing: Future Strategies

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Atlas of Ulcers in Systemic Sclerosis

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Abstract

Digital ulcers are a rather frequent and invalidating complication in systemic sclerosis, often showing a very slow or null tendency to heal, in spite of the commonly used systemic and local therapeutic procedures. Recently, stem cell therapy has emerged as a new approach to accelerate wound healing. Multipotent mesenchymal stromal cells are considered an attractive candidate for cell-based therapies because of their immunomodulatory, angiogenic, anti-inflammatory, and anti-apoptotic effects. Mesenchymal cells from the bone marrow have been first extensively characterized. Adipose tissue represents an additional abundant and accessible source of stem cells. At present, adipose-derived stem cells are one of the most attractive and promising sources of adult stem cells for cell therapy, finding a field of application in the treatment of scleroderma skin lesions, including digital ulcers.

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Authors and Affiliations

  1. Department of Rheumatology, ASST Gaetano Pini, Milan, Italy

    Nicoletta Del Papa, Eleonora Zaccara, Gabriele Di Luca & Wanda Maglione

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  1. Nicoletta Del Papa
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  2. Eleonora Zaccara
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  3. Gabriele Di Luca
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  4. Wanda Maglione
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Correspondence to Nicoletta Del Papa .

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  1. Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

    Marco Matucci-Cerinic

  2. Division of Medicine, University College London, Centre for Rheumatology, Royal Free Hospital, London, UK

    Christopher P. Denton

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Del Papa, N., Zaccara, E., Di Luca, G., Maglione, W. (2019). Adipose-Derived Stem Cells to Facilitate Ulcer Healing: Future Strategies. In: Matucci-Cerinic, M., Denton, C. (eds) Atlas of Ulcers in Systemic Sclerosis. Springer, Cham. https://doi.org/10.1007/978-3-319-98477-3_24

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