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Ulcer Healing and Prevention in Systemic Sclerosis

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Atlas of Ulcers in Systemic Sclerosis

Abstract

Digital ulcers (DU) have a major clinical impact in systemic sclerosis, and treatment and prevention are two logical and effective approaches to reduce the risk of complications and DU-related morbidity. Patient education, Raynaud’s phenomenon attacks control and identifications and treatment of potential risk factors for DU development are primary features of the above-mentioned approach. When this is not sufficient, different drug with shown evidences of efficacy in preventing or healing DU can be used, such as phosphodiesterase -5 inhibitors, endothelin-1 receptors antagonists and prostacyclin analogues, usually in combination with local topical treatment. Moreover, new approaches are also available, ranging from regenerative medicine to surgical procedures.

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Bruni, C., Bellando-Randone, S., Denton, C.P., Matucci-Cerinic, M. (2019). Ulcer Healing and Prevention in Systemic Sclerosis. In: Matucci-Cerinic, M., Denton, C. (eds) Atlas of Ulcers in Systemic Sclerosis. Springer, Cham. https://doi.org/10.1007/978-3-319-98477-3_20

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  • DOI: https://doi.org/10.1007/978-3-319-98477-3_20

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