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Melatonin

Abstract

Supplemental melatonin is one of the most commonly recommended biomedical agents for difficulty falling asleep or maintaining sleep in children with neurodevelopmental disorders. This chapter provides an overview of melatonin, its synthesis, and its biological properties. Dosing of melatonin in sleep disorders, its pharmacokinetics, side effects, and potential drug interactions are discussed. Available data on the use of melatonin for sleep in specific neurodevelopmental populations including autism, attention-deficit/hyperactivity disorder, Angelman syndrome, Rett syndrome, fragile X syndrome, tuberous sclerosis, epilepsy, and traumatic brain injury is reviewed.

Keywords

  • Melatonin
  • Circadian rhythm
  • Autism
  • Attention-deficit/hyperactivity disorder
  • Angelman syndrome
  • Rett syndrome
  • Fragile X syndrome
  • Tuberous sclerosis
  • Epilepsy
  • Traumatic brain injury
  • Insomnia
  • Sleep problems

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Fig. 31.1

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Leu, R.M. (2019). Melatonin. In: Accardo, J. (eds) Sleep in Children with Neurodevelopmental Disabilities. Springer, Cham. https://doi.org/10.1007/978-3-319-98414-8_31

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