Junctional Epidermolysis Bullosa
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Junctional epidermolysis bullosa (JEB) induces skin fragility slightly deeper in the basement membrane zone affecting the lamina lucida. It is most commonly inherited in an autosomal recessive manner. Mutations include LAMA3, LAMB3, LAMC2, COL17A1, ITGA6, ITGB4 corresponding to the proteins laminin-332, type XVII collagen, and alpha-6 beta-4 integrin.