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Mesenchymal Stem Cells as Vectors for Cancer Therapy

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Stem Cells for Cancer and Genetic Disease Treatment

Part of the book series: Stem Cells in Clinical Applications ((SCCA))

Abstract

Mesenchymal stem cells (MSCs) are common stem cells in the human body. They have various properties and functions, including migration to tumors. Based on this property, MSCs have been used as vectors to deliver anti-cancer agents to tumors. To date, MSCs have been modified to express some factors or agents, including interleukin (IL)-12, IL-14, IFN-beta, IFN-gamma, TRAIL, and suicide genes/enzymes. Currently, MSCs are being modified to deliver oncolytic viruses and drug-loaded nanoparticles. In this chapter, updated information on the applications of engineered MSCs for cancer therapy will be discussed.

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Abbreviations

5-FU:

5-fluorouracil

aaTSP-1:

Protein thrombospondin

ALL:

Acute lymphoblastic leukemia

bFGF:

Basic fibroblast growth factor

EGF:

Epidermal growth factor

EVs:

Extracellular vesicles

EWS:

Ewing sarcoma

GFP:

Green fluorescent protein

HGF:

Hepatic growth factor

hNSCs:

Human neural stem cells

HSV-TK:

Herpes simplex virus-1 thymidine kinase

HUVEC:

Human umbilical cord vein endothelial cells

IFN-β:

Interferon beta

IL:

Interleukin

MIF:

Migration inhibitory factor

MSCs:

Mesenchymal stem cells

NDV:

Newcastle disease virus

SDF:

Stromal derived factor

UC:

Umbilical cord

VEGF:

Vascular endothelial growth factor

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Acknowledgment

This study was supported by grant from the Ministry of Science and Technology via project No. DM.02.DA/15 “Assessment of the status, potential and capacity of research, application and development of stem cell technology in the field of medicine, pharmacy and agriculture.”

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Authors and Affiliations

  1. Laboratory of Stem Cell Research and Application & Stem Cell Institute & Cancer Research Laboratory, VNUHCM University of Science, Ho Chi Minh City, Vietnam

    Phuc Van Pham

  2. Laboratory of Stem Cell Research and Application & Stem Cell Institute, VNUHCM University of Science, Ho Chi Minh City, Vietnam

    Ngoc Bich Vu

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  1. Phuc Van Pham
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  2. Ngoc Bich Vu
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Correspondence to Phuc Van Pham .

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Editors and Affiliations

  1. Laboratory of Stem Cell Research and Application & Stem Cell Institute & Cancer Research Laboratory, VNUHCM University of Science, Ho Chi Minh City, Vietnam

    Phuc Van Pham

  2. University of Edinburgh - Zhejiang, International Campus (UoE-ZJU), Haining, Zhejiang, China

    Ahmed El-Hashash

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Van Pham, P., Vu, N.B. (2018). Mesenchymal Stem Cells as Vectors for Cancer Therapy. In: Pham, P., El-Hashash, A. (eds) Stem Cells for Cancer and Genetic Disease Treatment. Stem Cells in Clinical Applications. Springer, Cham. https://doi.org/10.1007/978-3-319-98065-2_2

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