Implantable Multisensory Microelectrode Biosensor for Revealing Neuron and Brain Functions

  • N. ManikandanEmail author
  • S. Muruganand
  • Karuppasamy
  • Senthil Subramanian
Conference paper
Part of the Springer Proceedings in Physics book series (SPPHY, volume 215)


Microelectrode and microprobe have been widely used to measure neuron activity. In recent times the implantable neural simulators have attracted more attention because of its potential ability and capability to the treatment of neural disorder. A traditional electrode has got signals from the neurons. Since every parameter of brain measures using separate sensors, it could be increasing the internal traffic as well as damage to the brain. Here we introduce microelectrode technology with a focus to achieve high resolution using multiple sensors in a single Microelectrode. The micro fabricated multielectrodes are fixed on silicon needles coupled to the simple, non-toxic and mild immobilization method based on PEGDE. It opens new possibilities for specific neurotransmitter detection in the central nervous system.


Bio MEMS Neural signal Pressure Temperature Multi sensor 



My special thanks to my guide Dr. S. Muruganand who gave full freedom to do this work, My glorious thanks to university grand commission (UGC) for their funding support in this research work. I express all Neurology doctor who gave anatomical tips for this research work.


  1. 1.
    R.D. Ponce Wong, J.D. Posner, V.J. Santos, Flexible microfluidic normal force sensor skin for tactile feedback. Sens. Actuators A 179, 62–69 (2012)CrossRefGoogle Scholar
  2. 2.
    L.-D. Liao, I.J. Wang, S.-F. Chen, J.-Y. Chang, C.-T. Lin, Design, fabrication and experimental validation of a novel dry-contact sensor for measuring electroencephalography signals without skin preparation. Sensors 11, 5819–5834 (2011)CrossRefGoogle Scholar
  3. 3.
    D. Eytan, N. Brenner, S. Marom, Selective adaptation in networks of cortical neurons. J. Neurosci. 23, 9349–9356 (2003)CrossRefGoogle Scholar
  4. 4.
    A. Spanne, P. Geborek, F. Bengtsson, H. Jorntell, Spike generation estimated from stationary spike trains in a variety of neurons in vivo. Front Cell Neurosci 8, 199 (2014). Scholar
  5. 5.
    H.-Y. Lai, L.-D. Liao, Design, simulation and experimental validation of a novel flexible neural probe for deep brain stimulation and multichannel recording. J. Neural Eng. 9, 036001 (2012). (15 pp) ADSCrossRefGoogle Scholar
  6. 6.
    T. Kose, K. Azgin, Design and fabrication of a high performance resonant MEMS temperature sensor. J. Micromech. Microeng. 26, 045012 (2016). (14 pp)ADSCrossRefGoogle Scholar
  7. 7.
  8. 8.
    N. Manikandan, Stimulation and analysis of flexible bio polymer cantilever based glucose sensor. Adv. Sci. Lett. 23(3), 1875–1877 (2017)CrossRefGoogle Scholar
  9. 9.

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • N. Manikandan
    • 1
    Email author
  • S. Muruganand
    • 1
  • Karuppasamy
    • 1
  • Senthil Subramanian
    • 2
  1. 1.Department of Electronics and InstrumentationBharathiar UniversityCoimbatoreIndia
  2. 2.Hindustan College of Science and TechnologyAgraIndia

Personalised recommendations