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Tumor Genetics and Cytogenetics: Solid Tumors

  • Natasha RekhtmanEmail author
  • Marina K Baine
  • Justin A. Bishop
Chapter

Abstract

Recurrent chromosomal translocations have traditionally been associated with leukemias/lymphomas and sarcomas. Translocations cause either formation of chimeric proteins (such as BCR-ABL) or abnormal protein expression (such as overexpression of c-Myc as a result of translocation into Ig promoter sequences in Burkitt lymphoma). In contrast, carcinomas generally have complex karyotypes with no recurrent translocations. Instead, carcinomas typically have activating mutations in proto-oncogenes (e.g., KRAS) or inactivation of tumor suppressor genes (e.g., TP53). In recent years this paradigm has shifted, and an increasing number of carcinomas are being recognized as having recurrent translocations. Notable examples are salivary carcinomas, pediatric renal cell carcinoma, thyroid carcinoma, and some lung adenocarcinomas.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Natasha Rekhtman
    • 1
    Email author
  • Marina K Baine
    • 2
  • Justin A. Bishop
    • 3
  1. 1.Department of PathologyMemorial Sloan Kettering Cancer CenterNew YorkUSA
  2. 2.Department of PathologyYale New Haven Hospital, Yale School of MedicineNew HavenUSA
  3. 3.Department of PathologyUniversity of Texas Southwestern Medical CenterDallasUSA

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