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Pharmacotherapy for Nocturia

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Abstract

This chapter presents the current state of knowledge of the pharmacotherapy of nocturia. An overview of the diagnostic evaluation is followed by discussion of the indications and efficacy of different classes of medications used to treat nocturia. Nocturia, defined as voiding that occurs during the hours of sleep, is common and bothersome. The underlying causes are multiple and diverse. Determining the underlying etiology is essential for choosing the appropriate therapy. Pharmacologic treatment should be guided by a thorough clinical evaluation and data derived from a frequency-volume chart. Possible medications include those for overactive bladder (OAB), those for benign prostatic hyperplasia, and those to reduce nocturnal urine production. A systematic approach is essential for the optimal treatment of nocturia. In the absence of nocturnal polyuria, medications for BPH or overactive bladder may be employed. NP is highly prevalent among patients with nocturia, however, and antidiuretic therapy should be considered when measures to address serious underlying etiologic conditions are ineffective.

Keywords

Nocturia Nocturnal polyuria Lower urinary tract pharmacotherapy Antimuscarinic therapy Overactive bladder Benign prostatic hyperplasia Antidiuretic pharmacotherapy Desmopressin 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Smith Institute for UrologyGreenlawnUSA
  2. 2.Department of UrologySUNY Downstate Medical CenterBrooklynUSA

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