Category II: Negative (for Malignancy)



The category “negative for malignancy” is used for specimens which are adequate for interpretation and do not contain material indicative of a benign neoplasm or a malignancy. Specimens assigned to this diagnostic category do not contain any cytologic or architectural abnormalities beyond those which can be assigned to reparative or reactive changes. The category “negative for malignancy” should be further categorized as a specific nonneoplastic lesion whenever possible. Entities included in the “negative” category are viral cytopathic changes, abscesses, fungal infections, and amyloid deposits among other pathologic processes.


Benign Reactive Fungus Abscess Amyloid Viral changes 


  1. 1.
    Nayak A, Sugrue C, Koenig S, Wasserman PG, Hoda S, Morgenstern NJ. Endobronchial ultrasound-guided transbronchial needle aspirate (EBUS-TBNA): a proposal for on-site adequacy criteria. Diagn Cytopathol. 2012;40:128–37.CrossRefGoogle Scholar
  2. 2.
    Cameron SE, Andrade RS, Pambuccian SE. Endobronchial ultrasound-guided transbronchial needle aspiration cytology: a state of the art review. Cytopathology. 2010;21:6–26.CrossRefGoogle Scholar
  3. 3.
    Levine MS, Weiss JM, Harrell JH, Cameron TJ, Moser KM. Trans- thoracic needle aspiration biopsy following negative fiberoptic bronchoscopy in solitary pulmonary nodules. Chest. 1988;93:1152–5.CrossRefGoogle Scholar
  4. 4.
    Bedrossian CW, Rybka DL. Bronchial brushing during fiberoptic bronchoscopy for the cytodiagnosis of lung cancer: comparison with sputum and bronchial washings. Acta Cytol. 1976;20:446–53.PubMedPubMedCentralGoogle Scholar

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Pathology and Anatomical SciencesUniversity of MissouriColumbiaUSA
  2. 2.Department of Pathology and Laboratory MedicineHospital of the University of PennsylvaniaPhiladelphiaUSA

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