Hypothesis Tests in Practice

  • Bryan Kestenbaum


A common task in clinical research studies is to test whether a characteristic of interest differs between two different groups in a given population. For example, research studies may wish to compare weight among children who are treated versus not treated with stimulant medications, cognitive function among adults with and without a specific genetic variant, or cardiac ejection fraction among persons with and without thyroid disease. Potential differences in these characteristics observed among the people in a particular study may or may not reflect true differences in the underlying population. Two-sample hypothesis tests are statistical procedures that make an inference about the difference in a characteristic between two groups in an underlying population.

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Bryan Kestenbaum
    • 1
  1. 1.Division of Nephrology, Department of MedicineUniversity of WashingtonSeattleUSA

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