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Pediatric Critical Care pp 323–339Cite as

Therapeutic Hypothermia in the Pediatric ICU

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Abstract

Therapeutic hypothermia (TH) is a complex therapy that has been shown to be robustly neuroprotective in experimental models of various neurologic conditions but has thus far been incompletely translated into patient care. Fever exacerbates neurologic injury and can contribute to worse patient outcomes. Patient temperature following neurologic insults has therefore become a vital sign to be continuously monitored and regulated. Targeted temperature management (TTM) encompasses both TH and the active prevention of fever (controlled normothermia). In this article, key literature is reviewed with a focus on traumatic brain injury (TBI) and hypoxic-ischemic brain injury, common situations associated with high morbidity and mortality in which clinicians are charged with the difficult task of making management decisions when the evidence is less than clear.

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Authors and Affiliations

  1. Critical Care Medicine, Children’s Mercy Hospital, Kansas City, MO, USA

    Jessica S. Wallisch

  2. Pediatrics, University of Missouri Kansas City, Kansas City, MO, USA

    Jessica S. Wallisch

  3. Critical Care Medicine, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA

    Ericka L. Fink

  4. Pediatrics, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA

    Ericka L. Fink

  5. Safar Center for Resuscitation Research, Pittsburgh, PA, USA

    Ericka L. Fink

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  1. Jessica S. Wallisch
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Correspondence to Ericka L. Fink .

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  1. Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA

    Christopher W. Mastropietro

  2. Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA

    Kevin M. Valentine

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Wallisch, J.S., Fink, E.L. (2019). Therapeutic Hypothermia in the Pediatric ICU. In: Mastropietro, C., Valentine, K. (eds) Pediatric Critical Care. Springer, Cham. https://doi.org/10.1007/978-3-319-96499-7_20

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